Pharmacokinetics and rectal bioavailability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients

Journal of Clinical Pharmacology

Volumn 41, Issue 5, 2001, Pages 536-541

  Tromm, A ^a   Mollmann H ^a   Barth, J ^a   Hochhaus, G ^a   Krieg, M ^a   Bigalke, C ^a   Mollmann A ^a   Derendorf, H ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE; HYDROCORTISONE ACETATE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; HUMAN; SIDE EFFECT;

ADMINISTRATION, RECTAL; ADULT; AGED; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMANS; HYDROCORTISONE; INFLAMMATORY BOWEL DISEASES; INTESTINAL ABSORPTION; METABOLIC CLEARANCE RATE; MIDDLE AGED; RECTUM;

EID: 0035028383     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700122010410     Document Type: Article

References (14)

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11. Pharmacokinetic interpretation of plasma cortisol and cortisone concentrations following a single oral administration of cortisone acetate to human subjects
12. Preliminary in vitro and in vivo investigations on methylprednisolone and its acetate
13. Suppression of plasma hydrocortisone levels: A poor estimate of rectal absorption of glucocorticoids