Cortisol metabolism and its inhibition by glycyrrhetinic acid in the isolated perfused human placental lobule

Journal of Steroid Biochemistry and Molecular Biology

Volumn 62, Issue 4, 1997, Pages 337-343

  Dodds, H M ^a,b   Taylor, P J ^b   Johnson, L P ^c   Mortimer, R H ^a,c   Pond, S M ^a,b   Cannell, G R ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCYRRHETINIC ACID;

ARTICLE; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MASS SPECTROMETRY; PLACENTA; TECHNIQUE;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLYCYRRHETINIC ACID; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; MASS SPECTROMETRY; PERFUSION; PLACENTA;

EID: 0030733303     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00039-3     Document Type: Article

References (25)

1. Seckl J. R., 11β-Hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation. European Journal of Clinical Investigation 23 (1993) 589-601.
2. Meigs R. A. and Engel L. L., Metabolism of neutral steroids by human tissues. Federation Proceedings 17 (1958) 274.
3. Meigs R. A. and Engel L. L., The metabolism of adrenocortical steroids by human tissues. Endocrinology 69 (1961) 152-162.
4. Levitz M., Jansen V. and Dancis J., The transfer and metabolism of corticosteroids in the perfused human placenta. American Journal of Obstetrics and Gynecology 132 (1978) 363-366.
5. Addison R. S., Maguire D. J., Mortimer R. H. and Cannell G. R., Metabolism of prednisolone by the isolated perfused human placental lobule. Journal of Steroid Biochemistry and Molecular Biology 39 (1991) 83-90.
6. Monder C., Stewart P. M., Lakshmi V., Valentino R., Bun D. Edwards C. R. W., Licorice inhibits corticosteroid 11 beta-de-hydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 125 (1989) 1046-1053.
7. Cannell G. R., Gluck R. M., Hamilton S. E., Mortimer R. H., Hooper W. D. and Dickinson R. G., Markers of physical integrity and physical viability of the perfused human placental lobule. Clinical and Experimental Pharmacology and Physiology 15 (1988) 837-844.
8. Dodds, H. M., Taylor, P. J., Cannell, G. R. and Pond, S. M., A high performance liquid chromatography-electrospray-tandem mass spectrometry analysis of Cortisol, cortisone, their 20-dihydro reduced and tetrahydro metabolites in placental perfusate. Analytical Biochemistry 247 (1997) 342-347.
9. Krouwer J. S. and Rabinowitz R., How to improve estimates of precision. Clinical Chemistry 30 (1984) 290-292.
10. Blanford A. T. and Pearson-Murphy B. E., In vitro metabolism of prednisolone, dexamethasone, betamethasone and Cortisol by the human placenta. American Journal of Obstetrics and Gynecology 126 (1977) 264-267.
11. Brown R. W., Chapman K. E., Kotelevtsev Y., Yau J. L., Lindsay R. S., Brett L., Leckie C., Murad P., Lyons V., Mullins J. J., Edwards C. R. and Seekl J. R., Cloning and production of antisera to human placental 11 β-hydroxysteroid dehydrogenase type 2. Biochemical Journal 313 (1996) 1007-1017.
12. Peterson R. E., Pierce C. E. and Kliman B., Isolation of 4pregnene-11 β, 17α, 20α, 21-tetrol-3-one from urine of man. Archives of Biochemistry and Biophysics 70 (1957) 614-617.
13. Schoneshofer M., Neber B. and Nigam S., Increase urinary excretion of free 20α-and 20β-dihydrocortisol in an hypercortisolemic but hypocortisoluric patient with Cushing's disease. Clinical Chemistry 29 (1983) 385-389.
14. Schoneshofer M., Neber B., Oelkers W., Nahoul K. and Mantero F., Measurement of urinary free 20 alpha-dihydrocortisol in biochemical diagnosis of chronic hypercorticoidism. Clinical Chemistry 32 (1986) 808-810.
15. 4-3-ketopregnene-20β-ol, two naturally occurring metabolites of progesterone. Journal of Clinical and Endocrinological Metabolism 18 (1958) 337-353.
16. 4-pregnene-20α-ol-3-one by human placenta in vitro. Acta Endocrinologica 30 (1959) 530-538.
17. Milewich L., Gant N. F., Schwarz B. E., Chen G. T. and MacDonald P. C., Initiation of human parturition: IX. Progesterone metabolism by placentas of early and late human gestation. Obstetrics and Gynecology 51 (1978) 278-280.
18. 4-Pregnen-20β-ol-3-on und 17α-Hydroxyprogesteron im Plasma der Nabelvene und der Nabelarterien. Klin. Wochenschrift 40 (1962) 453-456.
19. Addison R. S., Maguire D. J., Mortimer R. H., Roberts M. S. Cannell G. R., Pathway and kinetics of prednisolone metabolism in the human placenta. Journal of Steroid Biochemistry and Molecular Biology 44 (1993) 315-320.
20. Abe K., Suzuki A., Katayam H., Tatsumi Y. and Yumioka E., Determination of 18β-glycyrrhetinic acid in human plasma by high performance liquid chromatography. Journal of Chromatography (Biomedical Applications) 653 (1994) 112-115.
21. Krahenbuhl S., Hasler F. and Krapf R., Analysis and pharma-cokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals. Steroids 59 (1994) 121-126.
22. Hasler F., Krapf R., Brenneisen R., Bourquin D. and Krahenbuhl S., Determination of 18-beta-glycyrrhetinic acid in biological fluids from humans and rats by solid-phase extraction and high performance liquid chromatography. Journal of Chromatography (Biomedical Applications) 620 (1993) 73-82.
23. Okaya Y. and Haryuyama M., Simultaneous determination of glycyrrhizic acid and glycyrrhetinic acid in cosmetics by high performance liquid chromatography. Japanese Journal of Toxicology and Environmental Health 39 (1993) 303-310.
24. Kato H., Kanaoka M., Yano S. and Kobayashi M., 3-Monoglucuronyl-glycyrrhetinic acid is a major metabolite that causes licorice-induced psuedoaldosteronism. Journal of Clinical Endocrinology and Metabolism 80 (1995) 1929-1933.
25. Krahenbuhl S., Hasler F., Frey B. M., Frey F. J., Brenneisen R. and Krapf R., Kinetics and dynamics of orally administered 18-beta-glycyrrhetinic acid in humans. Journal of Clinical Endocrinology and Metabolism 78 (1994) 581-585.