Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris

Journal of Dermatological Science

Volumn 52, Issue 2, 2008, Pages 98-107

  Yamagami, Jun ^a   Takahashi, Hayato ^a   Ota, Takayuki ^a   Amagai, Masayuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen specific; Autoimmune disease; B cell; Pemphigus vulgaris

Indexed keywords

DESMOGLEIN 3; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT PROTEIN;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD; CASE REPORT; CELL ISOLATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE SEQUENCE; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOHISTOCHEMISTRY; MALE; PEMPHIGUS VULGARIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; DESMOGLEIN 3; FEMALE; FLOW CYTOMETRY; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN G; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEMPHIGUS;

EID: 51249083698     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2008.05.002     Document Type: Article

References (24)

1. Green K.J., and Gaudry C.A. Are desmosomes more than tethers for intermediate filaments?. Nat Rev Mol Cell Biol 1 (2000) 208-216
2. Amagai M., Klaus-Kovtun V., and Stanley J.R. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67 (1991) 869-877
3. Stanley J.R., and Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 355 (2006) 1800-1810
4. Amagai M., Hashimoto T., Shimizu N., and Nishikawa T. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 94 (1994) 59-67
5. Amagai M., Ahmed A.R., Kitajima Y., Bystryn J.C., Milner Y., Gniadecki R., et al. Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just "witnesses of disease"?. Exp Dermatol 15 (2006) 815-831
6. Ahmed A.R., Wagner R., Khatri K., Notani G., Awdeh Z., Alper C.A., et al. Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA 88 (1991) 5056-5060
7. Ahmed A.R., Yunis E.J., Khatri K., Wagner R., Notani G., Awdeh Z., et al. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA 87 (1990) 7658-7662
8. Miyagawa S., Higashimine I., Iida T., Yamashina Y., Fukumoto T., and Shirai T. HLA-DRB1*04 and DRB1*14 alleles are associated with susceptibility to pemphigus among Japanese. J Invest Dermatol 109 (1997) 615-618
9. Niizeki H., Inoko H., Mizuki N., Inamoto N., Watababe K., Hashimoto T., et al. HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method. Tissue Antigens 44 (1994) 248-251
10. Hertl M., Amagai M., Sundaram H., Stanley J., Ishii K., and Katz S.I. Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals. J Invest Dermatol 110 (1998) 62-66
11. Veldman C.M., Gebhard K.L., Uter W., Wassmuth R., Grotzinger J., Schultz E., et al. T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals. J Immunol 172 (2004) 3883-3892
12. Nishifuji K., Amagai M., Kuwana M., Iwasaki T., and Nishikawa T. Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: requirement of T cell collaboration for autoantibody production. J Invest Dermatol 114 (2000) 88-94
13. Leyendeckers H., Tasanen K., Bruckner-Tuderman L., Zillikens D., Sitaru C., Schmitz J., et al. Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies. J Invest Dermatol 120 (2003) 372-378
14. Payne A.S., Ishii K., Kacir S., Lin C., Li H., Hanakawa Y., et al. Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest 115 (2005) 888-899
15. Ishii K., Lin C., Siegel D.L., and Stanley J.R. Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J Invest Dermatol 128 (2008) 939-948
16. Qian Y., Diaz L.A., Ye J., and Clarke S.H. Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients. J Immunol 178 (2007) 5982-5990
17. Ishii K., Amagai M., Hall R.P., Hashimoto T., Takayanagi A., Gamou S., et al. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol 159 (1997) 2010-2017
18. Driver D.J., McHeyzer-Williams L.J., Cool M., Stetson D.B., and McHeyzer-Williams M.G. Development and maintenance of a B220- memory B cell compartment. J Immunol 167 (2001) 1393-1405
19. Tsunoda K., Ota T., Aoki M., Yamada T., Nagai T., Nakagawa T., et al. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 170 (2003) 2170-2178
20. Wardemann H., Yurasov S., Schaefer A., Young J.W., Meffre E., and Nussenzweig M.C. Predominant autoantibody production by early human B cell precursors. Science 301 (2003) 1374-1377
21. Cook G.P., and Tomlinson I.M. The human immunoglobulin VH repertoire. Immunol Today 16 (1995) 237-242
22. Collins A.M., Sewell W.A., and Edwards M.R. Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response. Pharmacol Ther 100 (2003) 157-170
23. Kuwana M., Nomura S., Fujimura K., Nagasawa T., Muto Y., Kurata Y., et al. Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood 103 (2004) 1229-1236
24. Shokrgozar M.A., Sam M.R., Amirkhani A., and Shokri F. Frequency analysis of HBsAg-specific B lymphocytes in high-responder individuals to recombinant hepatitis B vaccine: comparison of LDA and ELISPOT assays. Scand J Immunol 64 (2006) 536-543