Role of L-type Ca2+ channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia

Brain Research

Volumn 946, Issue 2, 2002, Pages 191-197

  Gullapalli, Srinivas ^a   Ramarao, Poduri ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Opioid analgesia

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; ISRADIPINE; KAPPA OPIATE RECEPTOR; NIMODIPINE; PERTUSSIS TOXIN; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DIHYDROPYRIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR AGONIST; SODIUM CHLORIDE; TRITIUM;

ANIMAL; ARTICLE; BODY TEMPERATURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MEMBRANE; METABOLISM; PAIN ASSESSMENT; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; BINDING AFFINITY; BINDING ASSAY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING; INDUCED HYPOTHERMIA; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TAIL FLICK TEST; TEMPERATURE; THERMOMETER;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANIMALS; BODY TEMPERATURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; INJECTIONS, INTRAVENTRICULAR; ISRADIPINE; MALE; MEMBRANES; NIMODIPINE; PAIN MEASUREMENT; PERTUSSIS TOXIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; ANIMAL; IN VITRO; SUPPORT, NON-U.S. GOV'T;

EID: 0037118936     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02880-9     Document Type: Article

References (47)

1. 2+ influx in rat spinal cord-dorsal root ganglion co-cultures: Involvement of a GTP-binding protein
2. Influence of pertussis toxin on thermic responses to morphine and neurotensin in rats
3. Effect of chronic administration of U-50,488H on tolerance to its pharmacological actions and on multiple opioid receptors in rat brain regions and spinal cord
4. i proteins and calcium in dynorphin-induced hypothermia and behavior
5. Effects of dynorphins on body temperature of rats
6. Opioid receptor-coupled second messengers
7. 2 selective activation of G-proteins
8. Calcium channel antagonists and adenosine analogues decrease tolerance to opiate pentazocine and U50488H
9. A method for determining loss of pain sensation
10. 2+ channel receptor protein in rat brain
11. 3H]nimodipine receptor binding in rat brain regions
12. Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice
13. Pharmacological in vitro studies of the new 1,4-dihydropyridine calcium antagonist lercanidipine
14. 2+ channels on the hypothermic response produced by activation of κ-opioid receptors
15. 2+ channel modulation by dihydropyridines potentiates κ-opioid receptor agonist induced acute analgesia and inhibits development of tolerance in rats
16. Effect of μ-, δ-, and κ-selective opioid agonists on thermoregulation in the rat
17. o, regulate neuronal calcium channels
18. Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen
19. Differential antagonism of bremazocine- and U69,593-induced antinociception by quadazocine: Further functional evidence of κ opioid receptor multiplicity in the Mouse
20. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein
21. Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells
22. z Coupling to the rat κ-opioid receptor
23. Second messengers in the transduction of multiple opioid receptor signals
24. + channels
25. Protein measurement with Folin phenol reagent
26. Modification of morphine-induced analgesia and toxicity by pertussis toxin
27. κ-Opioid receptors and analgesia
28. Interaction between analgesics and calcium channel blockers
29. Ligand: A versatile computerized approach for characterization of ligand-binding systems
30. Potentiation of κ opioid receptor agonist induced analgesia and hypothermia by fluoxetine
31. 3H]U-69,593 binding sites in rats brain: Evidence for κ-opioid receptor subtypes
32. 3H]nitrendipine binding to synaptic membranes: Similarity with morphine tolerance
33. Pertussis toxin inhibits the antinociceptive action of morphine in the rat
34. Pertussis toxin inhibits morphine analgesia and prevent opiate dependence
35. Interaction of κ receptor agonists with calcium channel antagonists in the modulation of hypothermia
36. Pertussis toxin abolishes the antinociception mediated by opioid receptors in rats spinal cord
37. Effects of calcium channel antagonists and Bay K 8644 on the analgesic response to pentazocine and U50,488H
38. Pertussis toxin in the analysis of receptor mechanisms
39. Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse
40. Time-dependent effects of in vivo pertussis toxin on morphine analgesia and G-proteins in mice
41. Pertussis and cholera toxins modulate κ-opioid receptor agonists-induced hypothermia and gut inhibition
42. Effect of ω-conotoxin and verapamil on antinociceptive, behavioural and thermoregulatory responses to opioids in the rat
43. G(z) can mediate the acute actions of μ- and κ-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization
44. U-50,488H: A selective and structurally novel non-μ (κ) opioid agonist
45. Intrathecal pertussis toxin treatment attenuates opioid antinociception and reduces high-affinity state of opioid receptors
46. 2 opioid receptors