The RNA-binding protein XSeb4R: A positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus

Genes and Development

Volumn 22, Issue 17, 2008, Pages 2347-2352

  Souopgui, Jacob ^a   Rust, Barbara ^b   Vanhomwegen, Jessica ^a   Heasman, Janet ^c   Henningfeld, Kristine A ^b   Bellefroid, Eric ^a   Pieler, Tomas ^b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Endoderm formation; RNA stability; Translational regulation; VegT; Xenopus; XSeb4R

Indexed keywords

MESSENGER RNA; PROTEIN VEGT; PROTEIN XSEB4R; RNA BINDING PROTEIN; T BOX TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; ENDODERM; GENE EXPRESSION; GERM LAYER; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RNA STABILITY; RNA TRANSLATION; XENOPUS;

ANIMALS; ENDODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM LAYERS; MESODERM; PROTEIN BIOSYNTHESIS; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; T-BOX DOMAIN PROTEINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 51149099267     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.479808     Document Type: Article

References (28)

1. Boy, S., Souopgui, J., Amato, M.A., Wegnez, M., Pieler, T., and Perron, M. 2004. XSEB4R, a novel RNA-binding protein involved in retinal cell differentiation downstream of bHLH proneural genes. Development 131: 851-862.
2. Cao, Y., Siegel, D., Donow, C., Knochel, S., Yuan, L., and Knochel, W. 2007. POU-V factors antagonize maternal VegT activity and β-Catenin signaling in Xenopus embryos. EMBO J. 26: 2942-2954.
3. Chicoine, J., Benoit, P., Gamberi, C., Paliouras, M., Simonelig, M., and Lasko, P. 2007. Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression. Dev. Cell 13: 691-704.
4. Claußen, M., Horvay, K., and Pieler, T. 2004. Evidence for overlapping, but not identical, protein machineries operating in vegetal RNA localization along early and late pathways in Xenopus oocytes. Development 131: 4263-4273.
5. Clements, D., Friday, R.V., and Woodland, H.R. 1999. Mode of action of VegT in mesoderm and endoderm formation. Development 126: 4903-4911.
6. Coller, J.M., Gray, N.K., and Wickens, M.P. 1998. mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation. Genes & Dev. 12: 3226-3235.
7. Gorgoni, B., Andrews, S., Schaller, A., Schümperli, D., Gray, N.K., and Müller, B. 2005. The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway. RNA 11: 1030-1042.
8. Gray, N.K., Coller, J.M., Dickson, K.S., and Wickens, M. 2000. Multiple portions of poly(A)-binding protein stimulate translation in vivo. EMBO J. 19: 4723-4733.
9. Harland, R.M. 1991. In situ hybridization: An improved whole-mount method for Xenopus embryos. Methods Cell Biol. 36: 685-695.
10. Heasman, J. 2006. Patterning the early Xenopus embryo. Development 133: 1205-1217.
11. Heasman, J., Wessely, O., Langland, R., Craig, E.J., and Kessler, D.S. 2001. Vegetal localization of maternal mRNAs is disrupted by VegT depletion. Dev. Biol. 240: 377-386.
12. Kofron, M., Demel, T., Xanthos, J., Lohr, J., Sun, B., Sive, H., Osada, S., Wright, C., Wylie, C., and Heasman, J. 1999. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors. Development 126: 5759-5770.
13. Lustig, K.D., Kroll, K.L., Sun, E.E., and Kirchner, M.W. 1996. Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development 122: 4001-4012.
14. Maris, C., Dominguez, C., and Allain, F.H. 2005. The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J. 272: 2118-2131.
15. Mowry, K.L. 1996. Complex formation between stage-specific oocyte factors and a. Xenopus mRNA localization element. Proc. Natl. Acad. Sci. 93: 14608-14613.
16. Niehrs, C., Steinbeisser, H., and De Robertis, E.M. 1994. Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid. Science 263: 817-820.
17. Nieuwkoop, P.D. and Faber, J. 1967. Normal table of Xenopus laevis (Daudin), 2nd ed. North Holland, Amsterdam.
18. Richter, J.D. 2007. CPEB: A life in translation. Trends Biochem. Sci. 32: 279-285.
19. Shu, L., Yan, W., and Chen, X. 2006. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes & Dev. 20: 2961-2972.
20. Sinner, D., Kirilenko, P., Rankin, S., Wei, E., Howard, L., Kofron, M., Heasman, J., Woodland, H.R., and Zorn, A.M. 2006. Global analysis of the transcriptional network controlhng Xenopus endoderm formation. Development 133: 1955-1966.
21. Stennard, F., Carnac, G., and Gurdon, J.B. 1996. The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation. Development 122: 4179-4188.
22. Stennard, F., Zorn, A.M., Ryan, K., Garrrett, N., and Gurdon, J.B. 1999. Differential expression of VegT and Antipodean protein isoforms in Xenopus. Mech. Dev. 86: 87-98.
23. Tran, U., Pickney, L.M., Ozpolat, B.D., and Wessely, O. 2007. Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros. Dev. Biol. 307: 152-164.
24. Wessely, O. and De Robertis, E.M. 2000. The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation. Development 127: 2053-2062.
25. Xanthos, J.B., Kofron, M., Wylie, C., and Heasman, J. 2001. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development 128: 167-180.
26. Xanthos, J.B., Kofron, M., Tao, Q., Schaible, K., Wylie, C., and Heasman, J. 2002. The roles of the three signaling pathways in the formation and function of the Spemann Organizer. Development 129: 4027-4043.
27. Zhang, J. and King, M.L. 1996. Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. Development 122: 4119-4129.
28. Zhang, J., Houston, D.W., King, M.L., Payne, C., Wylie, C., and Heasman, J. 1998. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell 94: 515-524.