Human thioredoxin exerts cardioprotective effect and attenuates reperfusion injury in rats partially via inhibiting apoptosis

Chinese Medical Journal

Volumn 121, Issue 9, 2008, Pages 819-826

  Wu, Xiao Wei ^a   Teng, Zong Yan ^a   Jiang, Li Hong ^a   Fan, Ying ^a   Zhang, Yu Hua ^a   Li, Xiu Rong ^a   Zhang, Yi Na ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cardioprotection; Mitochondria; Reperfusion; Thioredoxin

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; THIOREDOXIN; CARRIER PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; GENETICS; HEART MITOCHONDRION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; APOPTOSIS; CASPASE 3; HUMANS; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; RATS; RATS, WISTAR; THIOREDOXINS;

EID: 51149097128     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200805010-00013     Document Type: Article

References (29)

1. Eefting F, Rensing B, Wigman J, Pannekoek WJ, Liu WM, Cramer MJ, et al. Role of apoptosis in reperfusion injury. Cardiovasc Res 2004; 61: 414-426.
2. Misra A, Haudek SB, Knuefermann P, Vallejo JG, Chen ZJ, Michael LH, et al. Nuclear factor-κB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation 2003; 108: 3075-3078.
3. Lee P, Sata M, Lefer DJ, Factor SM, Walsh K, Kitsis RN. Fas pathway is a critical mediator of cardiac myocyte death and M1 during ischemia-reperfusion in vivo. Am J Physiol Heart Circ Physiol 2003; 284:H456-H463.
4. Holmgren A. Thioredoxin. Annu Rev Biochem 1985; 54: 237-271.
5. Berggren M, Gallegos A, Gasdaska JR, Gasdaska PY, Warneke J, Powis G. Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Res 1996; 16: 3459-3466.
6. Sasada T, Iwata S, Sato N, Kitaoka Y, Hirota K, Nakamura K, et al. Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity. Clin Invest 1996; 97: 2268-2276.
7. Takagi Y, Mitsui A, Nishiyama A, Nozaki K, Sono H, Gon Y, et al. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci U S A 1999; 96: 4131-4136.
8. Powis G, Mustacich D, Coon A. The role of-the redox protein thioredoxin in cell growth and cancer. Free Radic Biol Med 2000; 29: 312-322.
9. Masutani H. Bai J. Kim YC. Yodoi J. Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection. Mol Neurobiol 2004; 29: 229-242.
10. Nakamura H, De Rosa SC, Yodoi J, Holmgren A, Ghezzi P, Herzenberg LA, et al. Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS. Proc Natl Acad Sci U S A 2001; 98: 2688-2693.
11. Watson WH, Yang X, Choi YE, Jones DP, Kehrer JP. Thioredoxin and its role in toxicology. Toxicol Sci 2004; 78: 3-14.
12. + exchanger in hypoxia/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis. Eur J Pharmacol 2004; 486: 121-131.
13. Tao J, Xu H, Yang C. Effect of urocortin on L- type calcium currents in adult rat ventricular myocytes. Pharmacol Res 2004; 50: 471-476.
14. Gaffney AB, Callister MJ, Nakamura H. Thioredoxin: friend or foe in human disease? TRENDS Pharmaco Sci 2005; 26: 398-404.
15. Masutani H, Hirota K, Sasada T, Taniguchi YU, Taniguchi Y, Sono H, et al. Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax. Immunol Lett 1996; 54: 67-71.
16. Das KC. C-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation. Biol Chem 2001; 276: 4662-4670.
17. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J. AP-I transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A 1997; 94: 3633-3638.
18. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK)-1. EMBO J 1998; 17: 2596-2606.
19. Hashimoto S, Matsumoto K, Gon Y, Furuichi S, Maruoka S, Takeshita I, et al. Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 1999; 258: 443-447.
20. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways. Science 1997; 275: 90-94.
21. Tao L, Jiao XY, Gao E, Yuan YX, Lopez B, Christopher T, et al. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation 2006; 114: 1395-1402.
22. Turoczi T, Chang VW, Engelman RM, Maulik N, Ho YS, Das DK. Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing. J Mol Cell Cardiol 2003; 35: 695-704.
23. Maulik N, Yoshida T, Engelman RM, Deaton D, Flack JE, Rousou JA, et al. Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion. Mol Cell Cardiol 1998; 186:139-145. 5
24. Yeh ETH. Life and death in the cardiovascular system. Circulation 1997; 95: 782-786.
25. Bajaj G, Sharma RK. TNF-alpha-mediated cardiomyocyte apoptosis involves caspase-12 and calpam. Biochem Biophys Res Commun 2006; 345: 1558-64.
26. Gross A, McDonnell JM, Korsmeyer SJ. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-1911.
27. Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell 2002; 2: 55-67.
28. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, et al. Bcl-2 inhibits death of central neural cells induced by multipte agents. Proc Natl Acad Sci U S A 1993; 90: 4533-4537.
29. Yang L, Matthews RT, Schulz JB, Klockgether T, Liao AW, Martinou JC, et al. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. Neuroscience 1998; 18: 8145-8152.