Sirna targeting the IRF2 transcription factor inhibits leukaemic cell growth

International Journal of Oncology

Volumn 33, Issue 1, 2008, Pages 175-183

  Choo, Ailyn ^a   Palladinetti, Patricia ^a   Holmes, Tiffany ^a   Basu, Shreerupa ^a   Shen, Sylvie ^a   Lock, Richard B ^a   O'Brien, Tracey A ^a   Symonds, Geoff ^a   Dolnikov, Alla ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

Interferon regulatory factor 1 and 2; Leukaemogenesis

Indexed keywords

CD34 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1; INTERFERON REGULATORY FACTOR 2; MESSENGER RNA; SMALL INTERFERING RNA; CD14 ANTIGEN; IRF2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE TARGETING; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; POLYPLOIDY; PRIORITY JOURNAL; CELL CYCLE; DRUG ANTAGONISM; GENETICS; HEMATOPOIESIS; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, CD14; ANTIGENS, CD34; CELL CYCLE; CELL LINE, TUMOR; HEMATOPOIESIS; HUMANS; INTERFERON REGULATORY FACTOR-2; LEUKEMIA; RNA, SMALL INTERFERING;

EID: 51049121629     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.33.1.175     Document Type: Article

References (17)

1. Passegue E, Jamieson CHM, Ailles LE and Weissman IL: Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA 100: 11842-11849, 2003.
2. Shih LY, Huang CF, Wang PN, Wu JH, Lin TL, Dunn P and Kuo MC: Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia. Leukemia 18: 466-475, 2004.
3. Appelbaum FR, Rowe JM, Radich J and Dick JE: Acute myeloid leukemia. Hematology 2001: 62-86, 2001.
4. MacKenzie KL, Dolnikov A, Millington M, Shounan Y and Symonds G: Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood 93: 2043-2056, 1999.
5. Shen SW, Dolnikov A, Passioura T, Millington M, Wotherspoon S, Rice A, MacKenzie KL and Symonds G: Mutant N-ras preferentially drives human CD34(+) hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse. Exp Hematol 32: 852-860, 2004.
6. Passioura T, Dolnikov A, Shen S and Symonds G: N-ras-induced growth suppression of myeloid cells is mediated by IRF-1. Cancer Res 65: 797-804, 2005.
7. Abdollahi A, Lord KA, Hoffman-Liebermann B and Liebermann DA: Interferon regulatory factor-1 is a myeloid differentiation primary response gene induced by interleukin-6 and leukemia inhibitory factor: role in growth-inhibition. Cell Growth Differ 2: 401-407, 1991.
8. Green WB, Slovak ML, Chen IM, Pallavicini M, Hecht JL and Willman CL: Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31). Leukemia 13: 1960-1971, 1999.
9. Willman CL, Sever CE, Pallavicini MG, Harada H, Tanaka N, Slovak ML, Yamamoto H, Harada K, Meeker TC, List AF and Taniguchi T: Deletion of IRF-1, mapping to chromosome 5q31.1 in human leukemia and preleukemic myelodysplasia. Science 259: 968-971, 1993.
10. Guzman ML, Upchurch D, Grimes B, Howard DS, Rizzieri DA, Luger SM, Phillips GL and Jordan CT: Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. Blood 97: 2177-2179, 2001.
11. Passioura T, Shen S, Symonds G and Dolnikov A: A retroviral library genetic screen identifies IRF-2 as an inhibitor of N-ras-induced growth suppression in leukemic cells. Oncogene 24: 7327-7336, 2005.
12. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H and Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol 24: 6298-6310, 2004.
13. Perambakam S, Li B and Preisler H: Quantitation of interferon regulatory factor transcripts in patients with acute myeloid leukemia. Cancer Invest 19: 346-351, 2001.
14. Sledz CA, Holko M, De Veer MJ, Silverman RH and Williams BRG: Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834-839, 2003.
15. Grobe K and Powell LD: Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity. Blood 99: 3188-3196, 2002.
16. Woo RA and Poon RYC: Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev 18: 1317-1330, 2004.
17. Schepers H, Wierenga ATJ, Eggen BJL and Vellenga E: Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway. Exp Hematol 33: 747-757, 2005.