Tracking displacements of intracellular organelles in response to nanomechanical forces

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Volumn , Issue , 2008, Pages 1335-1338

  Silberberg, Yaron R ^a   Pelling, Andrew E ^a   Yakubov, Gleb E ^b   Crum, William R ^a   Hawkes, David J ^a   Horton, Mike A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Atomic force microscopy; Fluorescence microscopy; Mechanotransduction; Mitochondria; Nanomechanics; Particle tracking

Indexed keywords

ATOMIC FORCE MICROSCOPY; CELL DEATH; CELL GROWTH; ENZYME ACTIVITY; MICROSCOPIC EXAMINATION; PERTURBATION TECHNIQUES; TECHNICAL PRESENTATIONS;

FLUORESCENCE MICROSCOPY; MECHANOTRANSDUCTION; MITOCHONDRIA; NANOMECHANICS; PARTICLE TRACKING;

CELLS;

EID: 51049104259     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ISBI.2008.4541251     Document Type: Conference Paper

References (18)

1. G. Binnig, C. F. Quate, and C. Gerber, "Atomic Force Microscope," Physical Review Letters, vol. 56, pp. 930-933, 1986.
2. C. A. Putman, K. O. van der Werf, B. G. de Grooth, N. F. van Hulst, and J. Greve, "Viscoelasticity of living cells allows high resolution imaging by tapping mode atomic force microscopy.," Biophys. J., vol. 67, pp. 1749-1753, 1994.
3. M. Radmacher, R. W. Tillmann, M. Fritz, and H. E. Gaub, "From Molecules to Cells - Imaging Soft Samples with the Atomic Force Microscope," Science, vol. 257, pp. 1900-1905, 1992.
4. G. Charras and M. A. Horton, "Cellular mechanotransduction and its modulation: An Atomic Force Microscopy study," Biophysical Journal, vol. 80, pp. 305A-306A, 2001.
5. C. Rotsch, K. Jacobson, and M. Radmacher, "Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy," PNAS, vol. 96, pp. 921-926, 1999.
6. A. E. Pelling, S. Sehati, E. B. Gralla, J. S. Valentine, and J. K. Gimzewski, "Local Nanomechanical Motion of the Cell Wall of Saccharomyces cerevisiae," Science, vol. 305, pp. 1147-1150, 2004.
7. B. J. Haupt, A. E. Pelling, and M. A. Horton, "Integrated Confocal and Scanning Probe Microscopy for Biomedical Research," TheScientific World Journal, vol. 6, pp. 1609-1618, 2006.
8. I. F. Sbalzarini and P. Koumoutsakos, "Feature point tracking and trajectory analysis for video imaging in cell biology," Journal of Structural Biology, vol. 151, pp. 182-195, 2005.
9. J. A. Helmuth, C. J. Burckhardt, P. Koumoutsakos, U. F. Greber, and I. F. Sbalzarini, "A novel supervised trajectory segmentation algorithm identifies distinct types of human adenovirus motion in host cells," Journal of Structural Biology, vol. 159, pp. 347-358, 2007.
10. H. Ewers, A. E. Smith, I. F. Sbalzarini, H. Lilie, P. Koumoutsakos, and A. Helenius, "Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes," Proceedings of the National Academy of Sciences of the United States of America, vol. 102, pp. 15110-15115, 2005.
11. M. F. Langhorst, G. P. Solis, S. Hannbeck, H. Plattner, and C. A. O. Stuermer, "Linking membrane microdomains to the cytoskeleton: Regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin," Febs Letters, vol. 581, pp. 4697-4703, 2007.
12. C. Brunner, C. Wahnes, and V. Vogel, "Cargo pick-up from engineered loading stations by kinesin driven molecular shuttles," Lab on a Chip, vol. 7, pp. 1263-1271, 2007.
13. A. P. Manderson, J. G. Kay, L. A. Hammond, D. L. Brown, and J. L. Stow, "Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNF alpha," Journal of Cell Biology, vol. 178, pp. 57-69, 2007.
14. B. G. Sengers, M. Taylor, C. P. Please, and R. O. C. Oreffo, "Computational modelling of cell spreading and tissue regeneration in porous scaffolds," Biomaterials, vol. 28, pp. 1926-1940, 2007.
15. Y. R. Silberberg, A. E. Pelling, W. R. Crum, D. J. Hawkes, and M. A. Horton, "Mitochondrial Displacements in Response to Nanomechanical Forces," J. Molecular Recognit., pp. in press, 2007.
16. R. Levy and M. Maaloum, "Measuring the spring constant of atomic force microscope cantilevers: thermal fluctuations and other methods," Nanotechnology, vol. 13, pp. 33-37, 2002.
17. A. E. Pelling, D. W. Dawson, D. M. Carreon, J. J. Christiansen, R. R. Shen, M. A. Teitell, and J. K. Gimzewski, "Distinct contributions of microtubule subtypes to cell membrane shape and stability," Nanomedicine, vol. 3, pp. 43-52, 2007.
18. G. T. Charras and M. A. Horton, "Determination of Cellular Strains by Combined Atomic Force Microscopy and Finite Element Modeling," Biophys. J., vol. 83, pp. 858-879, 2002.