Bovine papillomaviruses, papillomas and cancer in cattle

Veterinary Research

Volumn 39, Issue 5, 2008, Pages

  Borzacchiello, Giuseppe ^a   Roperto, Franco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cancer; Cattle; Co factor; Papillomavirus; Viruses

Indexed keywords

CAPSID PROTEIN; ONCOPROTEIN; PROTEIN E6; PROTEIN E7; UNCLASSIFIED DRUG; VACCINE; VIRUS E5 PROTEIN;

BLADDER CANCER; BOVINE PAPILLOMAVIRUS TYPE 1; BOVINE PAPILLOMAVIRUS TYPE 2; BOVINE PAPILLOMAVIRUS TYPE 4; BRACKEN FERN; CATTLE DISEASE; GASTROINTESTINAL TUMOR; HISTOPATHOLOGY; IMMUNOSURVEILLANCE; MALIGNANT TRANSFORMATION; NONHUMAN; PAPILLOMA; PAPILLOMA VIRUS; REVIEW; TRANSCRIPTION REGULATION; VACCINATION; VIRUS CARCINOGENESIS; VIRUS GENOME; VIRUS IMMUNITY; VIRUS MORPHOLOGY; ANIMAL; ANIMAL DISEASE; CATTLE; CLASSIFICATION; GENETICS; NEOPLASM; VIROLOGY;

BOS; BOVINAE; BOVINE PAPILLOMAVIRUS TYPE 1; BOVINE PARVOVIRUS; EQUIDAE; HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRIDAE; PTERIDIUM AQUILINUM;

ANIMALS; CATTLE; CATTLE DISEASES; NEOPLASMS; PAPILLOMAVIRIDAE;

EID: 51049096566     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1051/vetres:2008022     Document Type: Review

References (144)

1. Abroi A., Ilves I., Kivi S., Ustav M., Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein, J. Virol. (2004) 78:2100-2113.
2. Alonso-Amelot M.E., Castillo U., Smith B.L., Lauren D.R., Bracken ptaquiloside in milk, Nature (1996) 382:587.
3. Alonso-Amelot M.E., Avendaño M., Human carcinogenesis and bracken fern: a review of the evidence, Curr. Med. Chem. (2002) 9:675-686.
4. Ambrosio V., Borzacchiello G., Bruno F., Galati P., Roperto F., Uroplakin expression in the urothelial tumors of cows, Vet. Pathol. (2001) 38:657-660.
5. Anderson R.A., Scobie L., O'Neil B.W., Grindlay G.J., Campo M.S., Viral proteins of bovine papillomavirus type 4 during the development of alimentary canal tumours, Vet. J. (1997) 154:69-78.
6. Antonsson A., Hansson B.G., Healthy skin ofmany animal species harbors papillomaviruses which are closely related to their human counterparts, J. Virol. (2002) 76:12537-12542.
7. Araibi E.H., Marchetti B., Ashrafi G.H., Campo M.S., Downregulation of major histocompatibility complex class I in bovine papillomas, J. Gen. Virol. (2004) 85:2809-2814.
8. Ashrafi G.H., Pitts J.D., Faccini A., McLean P., O'Brien V., Finbow M.E., Campo M.S., Binding of bovine papillomavirus type 4 E8 to ductin (16K proteolipid), down-regulation of gap junction intercellular communication and full cell transformation are independent events, J. Gen. Virol. (2000) 81:689-694.
9. Ashrafi G.H., Tsirimonaki E., Marchetti B., O'Brien P.M., Sibbet G.J., Andrew L., Campo M.S., Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins, Oncogene (2002) 21:248-259.
10. Balcos L.G., Borzacchiello G., Russo V., Popescu O., Roperto S., Roperto F., Association of Bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania, Res. Vet. Sci. (2008) 85:145-148.
11. Bastien N., McBride A.A., Interaction of the papillomavirus E2 protein with mitotic chromosomes, Virology (2000) 270:124-134.
12. Baxter M.K., McPhillips M.G., Ozato K., McBride A.A., The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein Brd4, J. Virol. (2005) 79:4806-4818.
13. Beniston R.G., Morgan I.M., O'Brien V., Campo M.S., Quercetin, E7 and p53 in papillomavirus oncogenic cell transformation, Carcinogenesis (2001) 22:1069-1076.
14. Bohl J., Hull B., Vande Pol S.B., Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins, J. Virol. (2001) 75:513-521.
15. Bonadies F., Borzacchiello G., Dezzi S., Nicoletti R., Roperto S., Mass spectrometric analysis of ptaquiloside, the toxic sesquiterpene from bracken fern, Rapid Commun. Mass Spectrom. (2004) 18:825-828.
16. Borzacchiello G., Ambrosio V., Galati P., Poggiali F., Venuti A., Roperto F., The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow, Vet. Pathol. (2001) 38:113-116.
17. Borzacchiello G., Ambrosio V., Galati P., Perillo A., Roperto F., Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows, Vet. Pathol. (2003) 40:455-459.
18. Borzacchiello G., Ambrosio V., Roperto S., Poggiali F., Tsirimonakis E., Venuti A., et al., Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of Italy, J. Comp. Pathol. (2003) 128:203-206.
19. Borzacchiello G., Iovane G., Marcante M.L., Poggiali F., Roperto F., Roperto S., Venuti A., Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows, J. Gen. Virol. (2003) 84:2921-2926.
20. Borzacchiello G., Ambrosio V., Leonardi L., Fruci R., Galati P., Roperto F., Rare tumours in domestic animals: a lipid cell variant of urothelial carcinoma of the urinary bladder in a cow and a case of vesical carcinosarcoma in a dog, Vet. Res. Commun. (2004) 28:273-274.
21. Borzacchiello G., Russo V., Gentile F., Roperto F., Venuti A., Nitsch L., et al., Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours, Oncogene (2006) 25:1251-1260.
22. Borzacchiello G., Russo V., Spoleto C., Roperto S., Balcos L., Rizzo C., et al., Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattle, Cancer Lett. (2007) 250:82-91.
23. Borzacchiello G., Bovine papillomavirus, in: Schwab M. (Ed.), Encyclopedia of Cancer, 2nd ed., Springer-Verlag, Germany, 2008.
24. Burkhardt A., Willingham M., Gay C., Jeang K.T., Schlegel R., The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranes, Virology (1989) 170:334-339.
25. Burnett S., Jareborg N., DiMaio D., Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue, Proc. Natl. Acad. Sci. USA (1992) 89:5665-5669.
26. Cairney M., Campo M.S., The synergism between bovine papillomavirus type 4 and quercetin is dependent on the timing of exposure, Carcinogenesis (1995) 16:1997-2001.
27. Campo M.S., Moar M.H., Jarrett W.F.H., Laird H.M., A new papillomavirus associated with alimentary cancer in cattle, Nature (1980) 286:180-182.
28. Campo M.S., McCaffery R.E., Doherty I., Kennedy I.M., Jarrett W.F.H., The Harvey ras 1 gene is activated in papillomavirus associated carcinomas of the upper alimentary canal in cattle, Oncogene (1990) 5:303-308.
29. Campo M.S., Jarrett W.F., Barron R., O'Neil B.W., Smith K.T., Association of bovine papillomavirus type 2 and bracken fern with bladder cancer in cattle, Cancer Res. (1992) 52:6898-6904.
30. Campo M.S., Grindlay G.J., O'Neil B.W., Chandrachud L.M., McGarvie G.M., Jarrett W.F.H., Prophylactic and therapeutic vaccination against a mucosal papillomavirus, J. Gen. Virol. (1993) 74:945-953.
31. Campo M.S., JarrettW.F., O'NeilW., Barron R.J., Latent papillomavirus infection in cattle, Res.Vet. Sci. (1994) 56:151-157.
32. Campo M.S., Jarrett W.F., Vaccination against cutaneous and mucosal papillomavirus in cattle. In vaccines against virally induced cancers, Ciba Found. Symp. (1994) 187:61-77.
33. Campo M.S., Bovine papillomavirus and cancer, Vet. J. (1997) 154:175-188.
34. Campo M.S., Vaccination against papillomavirus in cattle, Clin. Dermatol. (1997) 15:275-283.
35. Campo M.S., Animal model of papillomavirus pathogenesis, Virus Res. (2002) 89:249-261.
36. Campo M.S., Bovine papillomavirus: old system, new lessons?, in: Campo M.S. (Ed.), Papillomavirus research from natural history to vaccines and beyond, Caister Academic Press, Norfolk, 2006, pp. 373-383.
37. Carvalho T., Pinto C., Peleteiro M.C., Urinary bladder lesions in bovine enzootic haematuria, J. Comp. Pathol. (2006) 134:336-346.
38. Chandrachud L.M., O'Neil B.W., Jarrett W.F.H., Grindlay G.J.,McGarvie G.M., Campo M.S., Humoral immune response to the E7 protein of bovine papillomavirus type 4 and identification of B-cell epitopes, Virology (1994) 200:98-104.
39. Chandrachud L.M., Grindlay G.J., McGarvie G.M., O'Neil B.W., Wagner E.R., Jarrett W.H.F., CampoM.S., Vaccination of cattle with the N-terminus of L2 is necessary and sufficient for preventing infection by bovine papillomavirus-4, Virology (1995) 211:204-208.
40. Choy E., Chiu V.K., Silletti J., Feoktistov M., Morimoto T., Michaelson D., et al., Endomembrane trafficking of Ras: the CAAX motif targets proteins to the ER and Golgi, Cell (1999) 98:69-80.
41. Cohen B.D., Goldstein D.J., Rutledge L., Vass W.C., Lowy D.R., Schlegel R., Schiller J., Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domain, J. Virol. (1993) 67:5303-5311.
42. Connolly J.A., Morgan I.M., Jackson M.E., Campo M.S., The BPV-4 co-carcinogen quercetin induces cell cycle arrest and up-regulates transcription from the LCR of BPV-4, Oncogene (1998) 21:2739-2746.
43. Conrad M., Bubb V.J., Schlegel R., The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein, J. Virol. (1993) 67:6170-6178.
44. Day P.M., Schiller J.T., Early events in the papillomaviral life cycle, in: Campo M.S. (Ed.), Papillomavirus research from natural history to vaccines and beyond, Caister Academic Press, Norfolk, 2006, pp. 174-192.
45. DeMasi J., Huh K.W., Nakatani Y., Münger K., Howley P.M., Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding, Proc. Natl. Acad. Sci. USA (2005) 102:11486-11491.
46. DeMasi J., Chao M.C., Kumar A.S., Howley P.M., Bovine papillomavirus E7 oncoprotein inhibits anoikis, J. Virol. (2007) 81:9419-9425.
47. De Villiers E.M., Fauquet C., Broker T.R., Bernard H.U., zur Hausen H., Classification of papillomaviruses, Virology (2004) 324:17-27.
48. DiMaio D., Mattoon D., Mechanisms of cell transformation by papillomavirus E5 proteins, Oncogene (2001) 20:7866-7873.
49. Doorbar J., An emerging function for E4, Papillomavirus Report (1991) 2:145-148.
50. Drummond-Barbosa D.A., Vaillancourt R.R., Kazlauskas A., DiMaio D., Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signalling, Mol. Cell. Biol. (1995) 15:2570-2581.
51. Faccini A.M., Cairney M., Ashrafi G.H., Finbow M.E., Campo M.S., Pitts J.D., The bovine papillomavirus type 4 E8 protein binds to ductin and causes loss of gap junctional intercellular communication in primary fibroblasts, J. Virol. (1996) 70:9041-9045.
52. Ford J.N., Jennings P.A., Spradbrow P.B., Francis J., Evidence for papillomaviruses in ocular lesions in cattle, Res. Vet. Sci. (1982) 32:257-259.
53. Freitas R.N., O'Connor P.J., Prakash A.S., Shahin M., Povey A.C., Bracken (Pteridium aquilinum)-induced DNA adducts in mouse tissues are different from the adduct induced by the activated form of the bracken carcinogen ptaquiloside, Biochem. Biophys. Res. Commun. (2001) 281:589-594.
54. Gaukroger J.M., Chandrachud L.M., O'Neil B.W., Grindlay G.J., Knowles G., Campo M.S., Vaccination of cattle with bovine papillomavirus type 4 L2 elicits the production of virus-neutralizing antibodies, J. Gen. Virol. (1996) 77:1577-1583.
55. Gilhooly E.M, Rose D.P., The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines, Int. J. Oncol. (1999) 15:267-270.
56. Goldstein D.J., Finbow M.E., Andresson T., McLean P., Smith K., Bubb V., Schlegel R., Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H(+)-ATPases, Nature (1991) 352:347-349.
57. Goldstein D.J., Li W., Wang L.M., Heidaran M.A., Aaronson S., Shinn R., et al., The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation, J. Virol. (1994) 68:4432-4441.
58. Hamada M., Oyamada T., Yoshikawa H., Yoshikawa T., Morphological studies of esophageal papilloma naturally occurring in cattle, Nippon Juigaku Zasshi (1989) 51:345-351.
59. Hamata S., Nobumoto K., Kanno T., Genomic and phylogenetic analysis of two novel bovine papillomaviruses, BPV-9 and BPV-10, J. Gen. Virol. (2008) 89:158-163.
60. Hill F.W., Klein W.R., Hoyer M.J., Rutten V.P., Kock N., Koten J.W., et al., Antitumour effect of locally injected low doses of recombinant human interleukin-2 in bovine vulval papilloma and carcinoma, Vet. Immunol. Immunopathol. (1994) 41:19-29.
61. Holden P.R., McGuire B., Stoler A., Balmain A., Pitts J.D., Changes in gap junctional intercellular communication in mouse skin carcinogenesis, Carcinogenesis (1997) 18:15-21.
62. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 64, Human Papillomavirus, IARC, Lyon, France, 1995.
63. Ilves I., Kivi S., Ustav M., Long term episomal mantenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which is mediated by the viral E2 protein and its binding sites, J. Virol. (1999) 73:4404-4412.
64. Jackson M.E., Campo M.S., Both viral E2 protein and the cellular factor PEBP2 regulate transcription via E2 consensus sites within the bovine papillomavirus type 4 long control region, J. Virol. (1995) 10:6038-6046.
65. Jaggar R.T., Pennie W.D., Smith K.T., Jackson M.E., Campo M.S., Cooperation between bovine papillomavirus type 4 and ras in the morphological transformation of primary bovine fibroblasts, J. Gen. Virol. (1990) 71:3041-3046.
66. Jarrett W.F.H., McNeil P.E., Grimshaw W.T., Selman I.E., McIntyre W.I.M., High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus, Nature (1978) 274:215-217.
67. Jarrett W.F.H., The natural history of bovine papillomavirus infections, in: G. Klein (Ed.), Advances in Viral Oncology, vol. 5, Raven Press, New York, 1985, pp. 83-101.
68. Jarrett W.F.H., O'Neil B.W., Gaukroger J.M., Laird H.M., Smith K.T., Campo M.S., Studies on vaccination against papillomaviruses: a comparison of purified virus, tumour extracts and transformed cells in prophylactic vaccination, Vet. Rec. (1990) 126:449-452.
69. Jarrett W.F.H., O'Neil B.W., Gaukroger J.M., Smith K.T., Laird H.M., Campo M.S., Studies on vaccination against papillomaviruses: the immunity after infection and vaccination with bovine papillomaviruses of different types, Vet. Rec. (1990) 126:473-475.
70. Jarrett W.F.H., Smith K.T., O'Neil B.W., Gaukroger J.M., Chandrachud L.M., Grindlay G.J., et al., Studies on vaccination against papillomaviruses: prophylactic and therapeutic vaccination with recombinant structural proteins, Virology (1991) 184:33-42.
71. Jenson A.B., Lim P., Ghim S., Cowsert L., Olson C., Lim L.Y., et al., Identification of linear epitopes of the BPV-1 L1 protein recognized by sera of infected or immunized animals, Pathobiology (1991) 59:396-403.
72. Kirnbauer R., Booy F., Cheng N., Lowy D.R., Schiller J.T., Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic, Proc. Natl. Acad. Sci. USA (1992) 89:12180-12184.
73. Kirnbauer R., Chandrachud L.M., O'Neil B.W., Wagner E.R., Grindlay G.J., Armstrong A., et al., Virus-like particles of Bovine papillomavirus type-4 in prophylactic and therapeutic immunization, Virology (1996) 219:37-44.
74. Knowles G., O'Neil B.W., Campo M.S., Phenotypical characterization of lymphocytes infiltrating regressing papillomas, J. Virol. (1996) 70:8451-8458.
75. Lai C.C., Henningson C., DiMaio D., Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor, Proc. Natl. Acad. Sci. USA (1998) 95:15241-15246.
76. Lambert P.F., Papillomavirus DNA replication, J. Virol. (1991) 65:3417-3420.
77. Leal A.M., Ferraz O.P., Carvalho C., Freitas A.C., Beniston R.G., Campo M.S., et al., Quercetin induces structural chromosome aberrations and uncommon rearrangements in cells transformed by the E7 protein of BPV-4, Veterinary and Comparative Oncology (2003) 1:15-21.
78. Lehman C.W., Botchan M.R., Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation, Proc. Natl. Acad. Sci. USA (1998) 95:4338-4343.
79. Li T., Lu Z.M., Chen K.N., Guo M., Xing H.P., Mei Q., et al., Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China, Carcinogenesis (2001) 22:929-934.
80. Lioi M.B., Barbieri R., Borzacchiello G., Dezzi S., Roperto S., Santoro A., et al., Chromosome aberrations in cattle with chronic enzootic haematuria, J. Comp. Pathol. (2004) 131:233-236.
81. Marchetti B., Ashrafi T.H., Tsirimonaki E., O'Brien P.M., Campo M.S., The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface, Oncogene (2002) 51:7808-7816.
82. Marliere C., Galvao M.A.M., Wather P., Freitas R.N., Bracken fern consumption and oesophageal and gastric cancer in the Ouro Preto region, MG, Brazil, in: Taylor J.A. and Smith R.T. (Eds.), Bracken fern: Toxicity, Biology and Control, 1999, pp. 144-149.
83. Martin P., Vass W.C., Schiller J.T., Lowy D.R., Velu T.J., The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors, Cell (1989) 59:21-32.
84. Matsha T., Erasmus R., Kafuko A.B., Mugwanya D., Stepien A., Parker M.I., Human papillomavirus associated with esophageal cancer, J. Clin. Pathol. (2002) 55:587-590.
85. Mattoon D., Gupta K., Doyon J., Loll P.J., DiMaio D., Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein, Oncogene (2001) 20:3824-3834.
86. McGarvie G.M., Grindlay G.J., Chandrachud L.M., O'Neil B.W., Jarrett W.F., Campo M.S., T cell responses to BPV-4 E7 during infection and mapping of T cell epitopes, Virology (1995) 206:504-510.
87. Modis Y., Trus B.L., Harrison S.C., Atomic model of the papillomavirus capsid, EMBO J. (2002) 21:4754-4762.
88. Moura J.W., Stocco dos Santos R.C., Dagli M.L.Z., D'Angelino J.L., Birgel E.H., Beçak W., Chromosome aberrations in cattle raised on bracken fern pasture, Experientia (1988) 44:785-788.
89. Nilson L.A., DiMaio D., Platelet-derived growth factor receptor can mediate tumourigenic transformation by the bovine papillomavirus E5 protein, Mol. Cell. Biol. (1993) 13:4137-4145.
90. Nilson L.A., Gottlieb R.L., Polack G.W., DiMaio D., Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells, J. Virol. (1995) 69:5869-5874.
91. O'Brien V., Campo M.S., BPV-4 E8 transforms NIH3T3 cells, up-regulates cyclin A and cyclin A-associated kinase activity and de-regulates expression of the cdk inhibitor p27Kip1, Oncogene (1998) 17:293-301.
92. O'Brien V., Ashrafi G.H., Grindlay G.J., Anderson R., Campo M.S., A mutational analysis of the transforming functions of the E8 protein of bovine papillomavirus type 4, Virology (1999) 255:385-394.
93. O'Brien V., Grindlay G.J., Campo M.S., Cell transformation by the E5/E8 protein of bovine papillomavirus type 4: p27Kip1, Elevated through increased protein synthesis is sequestered by cyclin D1-CDK4 complexes, J. Biol. Chem. (2001) 276:33861-33868.
94. Oelze I., Kartenbeck J., Crusius K., Alonso A., Human papillomavirus type 16 E5 protein affects cell-cell communication in an epithelial cell line, J. Virol. (1995) 69:4489-4494.
95. Ogawa T., Tomita Y., Okada M., Shirasawa H., Complete genome and phylogenetic position of bovine papillomavirus type 7, J. Gen.Virol. (2007) 88:1934-1938.
96. Olson C., Pamukcu A.M., Brobst D.F., Papillomalike virus from bovine urinary bladder tumours, Cancer Res. (1965) 25:840-849.
97. Pamukcu A.M., Price J.M., Bryan G.T., Naturally occurring and bracken-fern-induced bovine urinary bladder tumours. Clinical and morphological characteristics, Vet. Pathol. (1976) 13:110-122.
98. Peixoto P.V., França T.N., Barros C.S.L., Tokarnia C.H., Histopathological aspects of Bovine Enzootic Hematuria in Brazil, Pesqui. Vet. Bras. (2003) 23:65-81.
99. Pennie W.D., Campo M.S., Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro, Virology (1992) 190:861-865.
100. Pennie W.D., Grindlay G.J., Cairney M., Campo M.S., Analysis of the transforming functions of bovine papillomavirus type 4, Virology (1993) 193:614-620.
101. Peretti V., Ciotola F., Albarella S., Russo V., Di Meo G.P., Iannuzzi L., et al., Chromosome fragility in cattle with chronic enzootic haematuria, Mutagenesis (2007) 22:317-320.
102. Petti L., Nilson L.A., DiMaio D., Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein, EMBO J. (1991) 10:845-855.
103. Petti L., DiMaio D., Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells, Proc. Natl. Acad. Sci. USA (1992) 89:6736-6740.
104. Pfister H., Linz U., Gissmann L., Huchthausen B., Hoffmann D., Zur Hausen H., Partial characterization of a new type of bovine papilloma viruses, Virology (1979) 96:1-8.
105. Pilacinski W.P., Glassman D.L., Glassman K.F., Reed D.E., Lum M.A., Marshall R.F., et al., Immunization against bovine papillomavirus infection, Ciba Found. Symp. (1986) 120:136-156.
106. Plaumann B., FritscheM., Rimpler H., Brandner G., Hess R.D., Flavonoids activate wild-type p53, Oncogene (1996) 13:1605-1614.
107. Prakash A.S., Pereira T.N., Smith B.L., Shaw G., Seawright A.A., Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside, Nat. Toxins (1996) 4:221-227.
108. Roberts S., Ashmole I., Johnson G.D., Kreider J.W., Gallimore P.H., Cutaneous and mucosal human papillomavirus E4 proteins form intermediate filament-like structures in epithelial cells, Virology (1993) 197:176-187.
109. Roden R.B., Weissinger E.M., Henderson D.W., Booy F., Kirnbauer R., Mushinski J.F., et al., Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins, J. Virol. (1994) 68:7570-7574.
110. Roperto S., Ambrosio V., Borzacchiello G., Galati P., Paciello O., Russo V., Roperto F., Bovine papillomavirus type-2 (BPV-2) infection and expression of uroplakin IIIb, a novel urothelial cell marker, in urinary bladder tumours of cows, Vet. Pathol. (2005) 42:812-818.
111. Roperto S., Borzacchiello G., Casellato R., Galati P., Russo V., Sonnino S., Roperto F., Sialic acid and GM3 ganglioside expression in papillomavirus-associated urinary bladder tumours of cattle with chronic enzootic haematuria, J. Comp. Pathol. (2007) 137:87-93.
112. Roperto S., Borzacchiello G., Brun R., Perillo A., Russo V., Urraro C., Roperto F., Multiple glomus tumors of the urinary bladder in a cow associated with bovine papillomavirus type 2 (BPV-2) infection, Vet. Pathol. (2008) 45:39-42.
113. Sardon D., de la Fuente I., Calonge E., Perez-Alenza M.D., Castaño M., Dunner S., Peña L., H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern, J. Comp. Pathol. (2005) 132:195-201.
114. Sarver N., Rabson M.S., Yang Y.C., Byrne J.C., Howley P.M., Localization and analysis of bovine papillomavirus type 1transforming functions, J. Virol. (1984) 52:377-388.
115. Schapiro F., Sparkowski J., Adduci A., Suprynowicz F., Schlegel R., Grinstein S., Golgi alkalinization by the papillomavirus E5 oncoprotein, J. Cell. Biol. (2000) 148:305-315.
116. Schiller J.T., Vass W.C., Vousden K.H., Lowy D.R., E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene, J. Virol. (1986) 57:1-6.
117. Schlegel R.,Wade-GlassM., Rabson M.S., Yang Y.C., The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polipeptide, Science (1986) 233:464-467.
118. Scobie L., Jackson M.E., Campo M.S., The role of exogenous p53 and E6 oncoproteins in in vitro transformation by bovine papillomavirus type 4 (BPV-4): significance of the absence of an E6 ORF in the BPV-4 genome, J. Gen. Virol. (1997) 78:3001-3008.
119. Settleman J., Fazeli A., Malicki J., Horwitz B.H., DiMaio D., Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein, Mol. Cell. Biol. (1989) 9:5563-5572.
120. Shahin M., Moore M.R., Worrall S., Smith B.L., Seawright A.A., Prakash A.S., H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: comparison of acute and chronic toxicity in rats, Biochem. Biophys. Res. Commun. (1998) 250:491-497.
121. Shahin M., Smith B.L., Worral S., Moore M.R., Seawright A.A., Prakash A.S., Bracken fern carcinogenesis: multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinomas in rats, Biochem. Biophys. Res. Commun. (1998) 244:192-197.
122. Shahin M., Smith B.L., Prakash A.S., Bracken carcinogens in the human diet, Mutat. Res. (1999) 443:69-79.
123. Sheng G.G., Shao J., Sheng H., Hooton E.B., Isakson P.C., Morrow J.D., et al., A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells, Gastroenterology (1997) 113:1883-1891.
124. Sibbet G., Romero-Graillet C., Meneguzzi G., Campo M.S., alpha6 integrin is not the obligatory cell receptor for bovine papillomavirus type 4, J. Gen. Virol. (2000) 81:327-334.
125. Skiadopoulos M.H., McBride A.A., Bovine papillomavirus type 1 genomes and the E2 transactivator protein are closely associated with mitotic chromatin, J. Virol. (1998) 72:2079-2088.
126. Smith B.L., The toxicity of bracken fern (genus Pteridium) to animals and its relevance to man, in: D'Mello J.P.F. (Ed.), Handbook of plant and fungal toxicants, CRC Press, Boca Raton, Florida, USA, 1997, pp. 63-76.
127. Sparkowski J., Mense M., Anders J., Schlegel R., E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation, J. Virol. (1996) 70:2420-2430.
128. Staebler A., Pierce J.H., Brazinski S., Heidaran M.A., Li W., Schlegel R., Goldstein D.J., Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein, J. Virol. (1995) 69:6507-6517.
129. Stocco dos Santos R.C., Lindsley C.J., Ferraz O.P., Pinto J.R., Mirandola R.S., Benesi F.J., et al., Bovine papillomavirus transmission and chromosomal aberrations: an experimental model, J. Gen. Virol. (1998) 79:2127-2135.
130. Sundberg J.P., Papillomavirus infections in animals, in: Syrjanen K. Gissmann L. Koss L. (Eds.), Papillomaviruses and Human Disease, Springer-Verlag, Heidelberg, Germany, 1987, pp. 40-103.
131. Sundberg J.P., VanRanst M., Burk R.D., Jenson A.B., The nonhuman (animal) papillomaviruses: host range, epitope conservation, and molecular diversity, in: Gross G., von Krogh G. (Eds.), Human Papillomavirus Infections in Dermatology and Venereology, CRC Press, Boca Raton, Florida, USA, 1996, pp. 47-68.
132. Suprynowicz F.A., Sparkowski J., Baege A., Schlegel R., E5 oncoprotein mutants activate phosphoinositide 3-kinase independently of platelet-derived growth factor receptor activation, J. Biol. Chem. (2000) 275:5111-5119.
133. Surti T., Klein O., Aschheim K., DiMaio D., Smith S.O., Structural models of the bovine papillomavirus E5 protein, Proteins (1998) 33:601-612.
134. Tomita Y., Literak I., Ogawa T., Jin Z., Shirasawa H., Complete genomes and phylogenetic positions of bovine papillomavirus type 8 and a variant type from European bison, Virus Genes (2007) 35:243-249.
135. Tong X., Salgia R., Li J.L., Griffin J.D., Howley P.M., The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase, J. Biol. Chem. (1997) 272:33373-33376.
136. Tong X., Boll W., Kirchhausen T., Howley P.M., Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1, J. Virol. (1998) 72:476-482.
137. Tsirimonaki E., O'Neil B.W., Williams R., Campo M.S., Extensive papillomatosis of the bovine upper gastrointestinal tract, J. Comp. Pathol. (2003) 129:93-99.
138. Väli U., Kilk A., Ustav M., Bovine papillomavirus oncoprotein E5 affects the arachidonic acid metabolism in cells, Int. J. Biochem. Cell Biol. (2001) 33:227-235.
139. Venuti A., Campo M.S., The E5 protein of papillomavirus, in: McCance D. (Ed.), Human Papillomavirus - Perspectives in Medical Virology, vol. 8, Elsevier Science, Amsterdam, 2002, pp. 143-164.
140. Wosiacki S.R., Barreiro M.A.B., Alfieri A.F., Alfieri A.A., Semi-nested PCR for detection and typing of bovine Papillomavirus type 2 in urinary bladder and whole blood from cattle with enzootic haematuria, J. Virol. Methods (2005) 126:215-219.
141. You J., Croyle J.L., Nishimura A., Ozato K., Howley P.M., Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes, Cell (2004) 117:349-360.
142. Zago M., Campo M.S, O'Brien V., Cyclin A expression and growth in suspension can be uncoupled from p27 deregulation and extracellular signal-regulated kinase activity in cells transformed by bovine papillomavirus type 4 E5, J. Gen. Virol. (2004) 85:3585-3595.
143. Zeng L., Zhou M.M., Bromodomain: an acetyl-lysine binding domain, FEBS Lett. (2002) 513:124-128.
144. Zimmermann H., Koh C.H., Degenkolbe R., O'Connor M.J., Müller A., Steger G., et al., Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53, J. Gen. Virol. (2000) 81:2617-2623.