E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2420-2430

  Sparkowski, Jason ^a   Mense, Mark ^a   Anders, Joanna ^a   Schlegel, Richard ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; INTERLEUKIN 3; LYSINE; MEMBRANE PROTEIN; MUTANT PROTEIN; ONCOPROTEIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SERINE; TYROSINE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; DISSOCIATION; FIBROBLAST; MOUSE; NONHUMAN; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BINDING;

EID: 0029869860     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2420-2430.1996     Document Type: Article

References (37)

1. --ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein. J. Biol Chem 270:6830-6837.
2. Band, U., D. Zajchowski, V. Kulesa, and R. Sager. 1990 Human papillomavirus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements Proc Natl. Acad. Sci USA 87:463-467
3. Burkhardt, A., M. Willingham, C. Gay, K.-T. Jeang, and R. Schlegel. 1989 The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranes Virology 170:2381-2385.
4. Cohen, B. D., D. J. Goldstein, L. Rutledge, W. C. Vass, D. R. Lowy, R. Schlegel, and J. T. Schiller. 1993. Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and epidermal growth factor receptor cytoplasmic domain. J. Virol. 67:5303-5311.
5. Cohen, B. D., D. R. Lowy, and J. T. Schiller. 1993. The conserved C-terminal domain of the bovine papillomavirus E5 oncoprotein can associate with an α-adaptin-like molecule. a possible link between growth factor receptors and viral transformation. Mol. Cell. Biol. 13:6462-6468.
6. DiFiore, P. P., J. H. Pierce, M. H. Kraus, O. Segatto, C. R. King, and S. A. Aaronson. 1987. erbB-2 is a potent oncogene when overexpressed in NIH/ 3T3 cells Science 237:178-182.
7. DiMaio, D., D. Guralski, and J. T. Schiller. 1986. Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity. Proc. Natl. Acad. Sci. USA 83:1797-1801.
8. Drummond-Barbosa, D., R. R. Vaillancourt, A. Kazlauskas, and D. DiMaio. 1995. Ligand-independent activation of the platelet-derived growth factor β receptor requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol. Cell. Biol. 15:2570-2581.
9. Dvoretzky, I., R. Shober, S. K. Chattopadhyay, and D. R. Lowy. 1980. A quantitative in-vitro assay for bovine papilloma virus. Virology 103:369-375.
10. Goldstein, D. J., T. Andresson, J. J. Sparkowski, and R. Schlegel. 1992. The BPV-1 E5 protein, the 16kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions. EMBO J. 11:4951-4959.
11. --ATPase. J. Virol. 66:405-413.
12. Goldstein, D. J., W. Li, L. Wang, M. A. Heidaran, S. Aaronson, R. Shinn, R. Schlegel, and J. Pierce. 1994. The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the β-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation J. Virol. 68:4432-4441.
13. Goldstein, D. J., and R. Schlegel. 1990. The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein. EMBO J. 9:137-146.
14. Greenberger, J. S., P. B. Davisson, P. J. Gans, and W. C. Moloney. 1979. In vitro induction of continuous acute promyelocytic cell lines by Friend or Abelson murine leukemia cell lines. Blood 53:987-1001.
15. Greenberger, J. S., M. A. Sakakeeny, R. K. Humphries, C. J. Eaves, and R. J. Eckner. 1983. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl Acad. Sci USA 80:2931-2935.
16. Groff, D., and W. D. Lancaster. 1986. Genetic analysis of the 3′ early region transformation and replication functions of bovine papillomavirus type 1. Virology 150:221-230.
17. Horwitz, B. H., A. Burkhardt, R. Schlegel, and D. DiMaio. 1988. 44-aminoacid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol. Cell Biol. 8:4071-4078.
18. Lancaster, W. D., and C. Olson. 1982. Animal papillomaviruses. Microbiol Rev. 46:191-207.
19. Lee, B. A., and D. J. Donoghue. 1991 Membrane-anchored form of v-SIS/ PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation J. Cell Biol. 113:361-370.
20. Lowy, D. R., I. Dvoretzky, M. F. Law, L. Engel, and P. M. Howley. 1980. In vitro tumorigenic transformation by a defined subgenomic fragment of bovine papillomavirus. Virology 103:369-375
21. Martin, P., W. C. Vass, J. T. Schiller, D. R. Lowy, and T. J. Velu. 1989 The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors. Cell 59:21-32
22. Nilson, L. A., and D. DiMaio. 1993. Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein. Mol. Cell. Biol. 13:4137-4145.
23. Nilson, L. A., R. L. Gottlieb, G. W. Polack, and D. DiMaio. 1995. Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous β receptor for platelet-derived growth factor in mouse C127 cells. J. Virol. 69:5869-5874.
24. Orth, G. 1987 Epidermodysplasia verruciformis, p. 199-243. In N. P. Salzman and P. M Howley (ed.), The Papovaviridae. Plenum Press, New York.
25. Petti, L., and D. DiMaio. 1992 Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells. Proc. Natl. Acad Sci. USA 89:8736-8740.
26. Petti, L., and D. DiMaio. 1994. Specific interaction between the bovine papillomavirus E5 transforming protein and the β receptor for platelet-derived growth factor in stably transformed and acutely transfected cells. J. Virol. 68:3582-3592.
27. Petti, L., L. Nilson, and D. DiMaio. 1991. Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein. EMBO J. 10:845-855.
28. Pierce, J. H., M. Ruggiero, T. P. Fleming, P. P. Di Fiore, J. S. Greenberger, L. Varticovski, J. Schlessinger, G. Rovera, and S. A. Aaronson. 1988. Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. Science 239:628-631.
29. Riese, D. J., and D. DiMaio. 1995. An intact PDGF-R signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein. Oncogene 10:1431-1439.
30. Schiller, J. T., W. C. Vass, K. H. Vousden, and D. R. Lowy. 1986 E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene. J. Virol. 57:1-6.
31. Schlegel, R., and M. Wade-Glass. 1987 E5 transforming polypeptide of bovine papillomavirus. Cancer Cells 5:87-91.
32. Schlegel, R., M. Wade-Glass, M. S. Rabson, and Y.-C. Yang. 1986. The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide. Science 233:464-467.
33. Sparkowski, J., J. Anders, and R. Schlegel. 1994. Mutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variants. J. Virol. 69:6120-6123.
34. Sparkowski, J., J. Anders, and R. Schlegel. 1995. E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF-receptor autophosphorylation but does not transform cells. EMBO J. 14:3055-3063
35. Staebler, A., J. H. Pierce, S. Brazinski, M. A. Heidaran, W. Li, R. Schlegel, and D. J. Goldstein. 1995. Mutational analysis of the β-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein. J. Virol. 69:6507-6517
36. Tada, A., H. Sekine, T. Yamamoto, A. Fuse, and B. Simuzu. 1989 Characterization of bovine papillomavirus type 1-transformed clones which show distinct transformed phenotypes. J. Gen. Virol. 70:1593-1599.
37. zur Hausen, H., and A. Schneider. 1987. The role of papillomaviruses in human anogenital cancer, p 245-263. In N. P. Salzman and P. M Howley (ed.), The Papovaviridae. Plenum Press, New York.