Interaction of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls

Journal of Bone and Mineral Metabolism

Volumn 26, Issue 5, 2008, Pages 493-498

  Xing, Li ^a,b   He, Guo Peng ^a   Chen, Yu Ming ^a   Su, Yi Xiang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Institute of Health Inspection   (China)

Author keywords

Association; Bone mineral density; Estrogen receptor; Interleukin 6 (IL 6); Polymorphism

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; INTERLEUKIN 6;

ADOLESCENT; ALLELE; ARTICLE; BONE DENSITY; BONE MASS; CALCIUM INTAKE; CHINA; COHORT ANALYSIS; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; FOLLOW UP; GENE INTERACTION; GENETIC ASSOCIATION; GENOTYPE; HIP; HORMONE BLOOD LEVEL; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MENARCHE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; BONE DENSITY; CHILD; CHINA; ESTROGEN RECEPTOR ALPHA; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-6; POLYMORPHISM, GENETIC; QUESTIONNAIRES;

EID: 50949118581     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-007-0844-y     Document Type: Article

References (36)

1. P.J. Kelly N.A. Morrison P.N. Sambrook T.V. Nguyen J.A. Eisman 1995 Genetic influences on bone turnover, bone density and fracture Eur J Endocrinol 133 265 271
2. Y.Z. Liu Y.J. Liu R.R. Recker H.W. Deng 2003 Molecular studies of identification of genes for osteoporosis: the 2002 update J Endocrinol 177 147 196
3. N.C. Ho L. Jia C.C. Driscoll E.M. Gutter C.A. Francomano 2000 A skeletal gene database J Bone Miner Res 15 2095 2122
4. S.C. Manolagas R.L. Jilka 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis N Engl J Med 332 305 311
5. S.C. Manolagas 1998 The role of IL-6 type cytokines and their receptors in bone Ann NY Acad Sci 840 194 204
6. P. Garnero O. Borel E. Sornay-Rendu F. Duboeuf R. Jeffery P. Woo P.D. Delmas 2002 Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: The OFELY study Bone 31 43 50
7. N. Ota T. Nakajima I. Nakazawa T. Suzuki T. Hosoi H. Orimo S. Inoue Y. Shirai M. Emi 2001 A Nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density J Hum Genet 46 267 272
8. T.C. Spelsberg M. Subramaniam B.L. Riggs S. Khosla 1999 The actions and interactions of sex steroids and growth factors/cytokines on the skeleton Mol Endocrinol 13 819 828
9. S. Mitra M. Desai M.I. Khatkhatay 2006 Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women Mol Genet Metab 87 1 80 87
10. L. Becherini L. Gennari L. Masi R. Mansani F. Massart A. Morelli A. Falchetti S. Gonnelli G. Fiorelli A. Tanini M.L. Brandi 2000 Evidence of linkage disequilibrium between polymorphisms in the human estrogen receptor-α gene and their relationship to bone mass variation in postmenopausal Italian women Hum Mol Genet 9 2043 2050
11. L. Gennari L. Becherini L. Masi R. Mansani S. Gonnelli C. Cepollaro S. Martini A. Montagnani G. Lentini A.M. Becorpi M.L. Brandi 1998 Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution to bone mineral density J Clin Endocrinol Metab 83 939 944
12. L. Rifas J.S. Kenney M. Marcelli R. Pacifici S.L. Cheng L.L. Dawson L.V. Avioli 1995 Production of interleukin-6 in human osteoblasts and human bone marrows tromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-alpha is not regulated by ovarian steroids Endocrinology 136 9 4056 4067
13. M. Willing M. Sowers D. Aron M.K. Clark T. Burns C. Bunten M. Crutchfield D. D'Agostino M. Jannausch 1998 Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction J Bone Miner Res 13 4 695 705
14. M. Nasu T. Sugimoto H. Kaji K. Chihara 2000 Estrogen modulates osteoblast proliferation and function regulated by parathyroid hormone in osteoblastic SaOS-2 cells: role of insulin-like growth factor (IGF)-I and IGF-binding protein-5 J Endocrinol 167 2 305 313
15. A.G. Uitterlinden A.E. Weel H. Burger Y. Fang C.M. van Duijn A. Hofman J.P. van Leeuwen H.A. Pols 2001 Interaction between the vitamin D receptor gene and collagen type alpha gene in susceptibility for fracture J Bone Miner Res 16 2 379 385
16. N. Garcia-Giralt X. Nogues A. Enjuanes J. Puig L. Mellibovsky A. Bay-Jensen R. Carreras S. Balcells A. Diez-Perez D. Grinberg 2000 Two new single-nucleotide polymorphisms in the COL1A1 upstream regulatory region and their relationship to bone mineral density J Bone Miner Res 17 3 384 393
17. P.R.E. Crocker D.A. Bailey R.A. Faulkner K.C. Kowalski R. McGrath 1997 Measuring general levels of physical activity: preliminary evidence for the Physical Activity Questionnaire for Children Med Sci Sports Exerc 29 10 1344 1349
18. S.L. Ferrari P. Garnero S. Emond H. Montgomery S.E. Humphries S.L. Greenspan 2001 A functional polymorphic variant in the interlrukin-6 gene promoter associated with low bone resorption in postmenopausal women Arthritis Rheum 44 196 201
19. S.F. Lei Y.Z. Liu F.Y. Deng Y.M. Li M.X. Li H.W. Deng 2005 Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese J Bone Miner Metab 23 4 323 328
20. S. Kobayashi S. Inoues T. Hosoi Y. Ouchi M. Shiraki H. Orimo 1996 Association of bone mineral density with polymorphism of the estrogen receptor gene J Bone Miner Res 11 306 311
21. Cohen J (1988) The analysis of variance and covariance. In: Statistical Power Analysis for the Behavioural Sciences, 2nd edn. Erlbaum Associates, Hillsdale, NJ, pp 273-406
22. L.A. Rubin G.A. Hawker V.D. Peltekova L.J. Fielding R. Ridout D.E. Cole 1999 Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort J Bone Miner Res 14 633 643
23. T. Hayakawa T. Takamura A. Hisada T. Abe G. Nomura K. Kobayashi 2001 IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and type II diabetes mellitus in Japanese men Diabetologia 45 453 454
24. R. Zhai G. Liu C. Yang C. Huang C. Wu D.C. Christiani 2001 The G to C polymorphism at -174 of the interleukin-6 gene is rare in the Southern Chinese population Pharmacogenetics 11 699 701
25. S.F. Lei F.Y. Deng X.H. Liu Q.R. Huang Y.J. Qin Q. Zhou D.K. Jiang Y.M. Li X.Y. Mo M.Y. Liu X.D. Chen X.S. Wu H. Shen V. Dvornyk L.J. Zhao R.R. Recker H.W. Deng 2003 Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity J Bone Miner Metab 21 34 42
26. Y. Yamada F. Ando N. Niino H. Shimokata 2003 Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men J Clin Endocrinol Metab 88 7 3372 3378
27. N. Ota T. Nakajima I. Nakazawa T. Suzuki T. Hosoi H. Orimo S. Inoue Y. Shirai M. Emi 2001 A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density J Hum Genet 46 267 272
28. Q. Huang Q. Wang L. Zhang J. Liu Q. Zhou Y. Liu J. He F. Lin 1999 Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China Chin Med J (Engl) 112 9 832 835
29. T. Salmen A.M. Heikkinen A. Mahonen H. Kroger M. Komulainen S. Saarikoski R. Honkanen P.H. Maenpaa 2000 Early postmenopausal bone loss is associated with PvuII estrogen receptor gene polymorphism in Finnish women: effect of hormone replacement therapy J Bone Miner Res 15 315 321
30. M. Willing M. Sowers D. Aron M.K. Clark T. Burns C. Bunten M. Crutchfield D. D'Agostino M. Jannausch 1998 Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction J Bone Miner Res 13 695 705
31. E. Dennison H. Syddall C. Fall M.L. Brandi C. Cooper Hertfordshire Cohort Study Group 2005 Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study J Rheumatol 32 12 2400 2404
32. W.X. Jian Y.J. Yang J.R. Long Y.N. Li F.Y. Deng D.K. Jiang H.W. Deng 2005 Estrogen receptor alpha gene relationship with peak bone mass and body mass index in Chinese nuclear families J Hum Genet 50 9 477 482
33. R. Nishimura K. Moriyama K. Yasukawa G.R. Mundy T. Yoneda 1998 Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells J Bone Miner Res 13 5 777 785
34. R. Pacifici 1996 Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis J Bone Miner Res 11 8 1043 1051
35. G. Girasole R.L. Jilka G. Passeri S. Boswell G. Boder D.C. Willams S.C. Manolagas 1996 17-Beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens J Clin Invest 89 3 883 891
36. B. Abrahamsen V. Bonnevie-Nielsen E.N. Ebbesen J. Gram H. Beck-Nielsen 2000 Cytokines and bone loss in a 5-year longitudinal study: hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: the Danish Osteoporosis Prevention Study J Bone Miner Res 15 8 1545 1554