Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

Archiv der Pharmazie

Volumn 341, Issue 6, 2008, Pages 344-350

  Rodrigues, Tiago ^a   Moreira, Rui ^a   Guedes, Rita C ^a   Iley, Jim ^b   Lopes, Francisca ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b OPEN UNIVERSITY   (United Kingdom)

Author keywords

Acyloxymethylation; Indole; Prodrugs; Sumatriptan

Indexed keywords

4 METHOXYBENZOYLOXYMETHYLSUMATRIPTAN; INDOLE; N ACYLOXYMETHYLSUMATRIPTAN DERIVATIVE; NITROGEN; PIVALOYLOXYMETHYLSUMATRIPTAN; PRODRUG; SEROTONIN AGONIST; SULFONAMIDE; SUMATRIPTAN; UNCLASSIFIED DRUG; BUFFER; DRUG DERIVATIVE; INDOLE DERIVATIVE;

ACYLOXYMETHYLATION; ARTICLE; DRUG DESIGN; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; METHYLATION; PH; PLASMA; PRIORITY JOURNAL; BLOOD; CHEMISTRY; METABOLISM; SOLUBILITY; SYNTHESIS;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INDOLES; METHYLATION; PRODRUGS; SEROTONIN AGONISTS; SOLUBILITY; SUMATRIPTAN;

EID: 50949107913     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700250     Document Type: Article

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