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Volumn 32, Issue 7, 2008, Pages 499-504

Chiral analysis of methadone and its main metabolite EDDP in postmortem blood by liquid chromatography-mass spectrometry

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 1,5 DIMETHYL 3,3 DIPHENYLPYRROLINIUM; ACETIC ACID DERIVATIVE; ACETONITRILE; AMMONIUM ACETATE; BUTYL ACETATE; DRUG METABOLITE; METHADONE; SODIUM HYDROXIDE; WATER;

EID: 50949101198     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.7.499     Document Type: Article
Times cited : (19)

References (20)
  • 2
    • 0029941892 scopus 로고    scopus 로고
    • Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: Interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics
    • C.B. Eap, T. Finkbeiner, M. Gastpar, N. Scherbaum, K. Powell, and P. Baumann. Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics. Eur. J. Clin. Pharmacol. 50: 385-389 (1996).
    • (1996) Eur. J. Clin. Pharmacol , vol.50 , pp. 385-389
    • Eap, C.B.1    Finkbeiner, T.2    Gastpar, M.3    Scherbaum, N.4    Powell, K.5    Baumann, P.6
  • 3
    • 0033747394 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients
    • D.J.R. Foster, A.A. Somogyi, K.R. Dyer, J.M. White, and F. Bochner. Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients. Br. J. Clin. Pharmacol. 50: 427-440 (2000).
    • (2000) Br. J. Clin. Pharmacol , vol.50 , pp. 427-440
    • Foster, D.J.R.1    Somogyi, A.A.2    Dyer, K.R.3    White, J.M.4    Bochner, F.5
  • 4
    • 0346728533 scopus 로고    scopus 로고
    • Automated LC-MS method for the fast stereoselective determination of methadone in plasma
    • S. Souverain, C. Eap, J.L. Veuthey, and S. Rudaz. Automated LC-MS method for the fast stereoselective determination of methadone in plasma. Clin. Chem. Lab. Med. 41: 1615-1621 (2003).
    • (2003) Clin. Chem. Lab. Med , vol.41 , pp. 1615-1621
    • Souverain, S.1    Eap, C.2    Veuthey, J.L.3    Rudaz, S.4
  • 5
    • 10844247369 scopus 로고    scopus 로고
    • Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure
    • T.B. Mitchell, K.R. Dyer, D. Newcombe, A. Salter, A.A. Somogyi, F. Bochner, and J.M. White. Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure. Br. J. Clin. Pharmacol. 58: 609-617 (2004).
    • (2004) Br. J. Clin. Pharmacol , vol.58 , pp. 609-617
    • Mitchell, T.B.1    Dyer, K.R.2    Newcombe, D.3    Salter, A.4    Somogyi, A.A.5    Bochner, F.6    White, J.M.7
  • 6
    • 17444421220 scopus 로고    scopus 로고
    • Determination of total and free concentrations of the enantiomers of methadone and its metabolite in human plasma by enantioselective liquid chromatography with mass spectrometric detection
    • M.E. Rodriguez-Rosas, J.G. Medrano, D.H. Epstein, E.T. Moolchan, K.L. Preston, and I.W. Wainer. Determination of total and free concentrations of the enantiomers of methadone and its metabolite in human plasma by enantioselective liquid chromatography with mass spectrometric detection. J. Chromatogr. A 1073: 237-248 (2005).
    • (2005) J. Chromatogr. A , vol.1073 , pp. 237-248
    • Rodriguez-Rosas, M.E.1    Medrano, J.G.2    Epstein, D.H.3    Moolchan, E.T.4    Preston, K.L.5    Wainer, I.W.6
  • 7
    • 0028970418 scopus 로고
    • 2, δ, κ opioid receptor binding profiles of methadone stereoisomers and morphine
    • 2, δ, κ opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sci. 56: 45-50 (1995).
    • (1995) Life Sci , vol.56 , pp. 45-50
    • Kristensen, K.1    Christensen, C.B.2    Christrup, L.L.3
  • 11
    • 5344251220 scopus 로고    scopus 로고
    • Quantification of methadone in forensic samples by LC-MS-MS
    • Prague, Czech Republic
    • S.S. Johansen. Quantification of methadone in forensic samples by LC-MS-MS. TIAFT Proceedings, Prague, Czech Republic, 2001, pp 412-415.
    • (2001) TIAFT Proceedings , pp. 412-415
    • Johansen, S.S.1
  • 15
    • 0038300714 scopus 로고    scopus 로고
    • Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics
    • M. Schulz and A. Schmoldt. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58: 447-474 (2003).
    • (2003) Pharmazie , vol.58 , pp. 447-474
    • Schulz, M.1    Schmoldt, A.2
  • 18
    • 0025212634 scopus 로고
    • The forensic science implications of site and temporal influences on postmortem blood-drug concentrations
    • R.W. Prouty and W.H. Anderson. The forensic science implications of site and temporal influences on postmortem blood-drug concentrations. J. Forensic Sci. 35: 243-270 (1990)
    • (1990) J. Forensic Sci , vol.35 , pp. 243-270
    • Prouty, R.W.1    Anderson, W.H.2
  • 20
    • 0016712628 scopus 로고
    • Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment
    • K. Verebely, J. Volavka, S. Mule, and R. Resnick. Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment. Clin. Pharmacol. Ther. 18: 180-190 (1975).
    • (1975) Clin. Pharmacol. Ther , vol.18 , pp. 180-190
    • Verebely, K.1    Volavka, J.2    Mule, S.3    Resnick, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.