Vitamin E supplementation, beneficial or harmful?;Suplementación con vitamina E, ¿benéfica o dañina?

Gaceta Medica de Mexico

Volumn 144, Issue 2, 2008, Pages 147-154

  Blé Castillo, Jorge Luis ^a   Díaz Zagoya, Juan C ^b   Méndez, José D ^c  

^a Hospital General de Zona IMSS   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c HOSPITAL DE ESPECIALIDADES   (Mexico)

Author keywords

tocopherol; Antioxidant; Mortality; Supplementation; Toxicity

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; BETA TOCOPHEROL; CYCLOOXYGENASE 2; DELTA TOCOPHEROL; GAMMA TOCOPHEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PRAVASTATIN; PROTEIN KINASE C;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CLINICAL TRIAL; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; MORTALITY; NONHUMAN; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; RISK BENEFIT ANALYSIS; SIGNAL TRANSDUCTION; STEREOISOMERISM; TRANSCRIPTION REGULATION; VITAMIN SUPPLEMENTATION;

ANTIOXIDANTS; DIETARY SUPPLEMENTS; HUMANS; VITAMIN E;

EID: 50949091621     PISSN: 00163813     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Evans HM, Bishop KS. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 1922;56:650-651.
2. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids. Washington, DC: National Academy Press; 2000.
3. nd edition. New York: Oxford University Press; 1999.
4. Traber MG, Sies H. Vitamin E in humans: demand and delivery. Annu Rev Nutr 1996; 16:321-347.
5. Bauernfeind JB. Tocopherols in food. Vitamin E. A comprehensive treatise. New York: Marcel Dekker I; 1980 pp. 99-167.
6. Catignani GL, Bieri JG. Rat liver alpha-tocopherol binding protein. Biochim Biophys Acta 1977; 497:349-357.
7. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, et al. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS. Lett 1997; 409:105-158.
8. Goti D, Reicher H, Malle E, Kostner GM, Panzenboeck U, Sattler W. High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles. Biochem J 1998;332:57-65.
9. Fechner H, Schlame M, Guthmann F, Stevens PA, Rustow B. Alpha and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA. Biochem J 1998;331:577-581.
10. Yokota T, Shiojiri T, Gotoda T, Arita M, Arai H, Ohga T, et al. Friedreich-like ataxia with retinitis pigmentosa caused by the His101Gln mutation of the alpha-tocopherol transfer protein gene. Ann Neurol 1997; 41:826-832.
11. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, et al. Increased atherosclerosis in hyperlipidemic mice deficient in alpha-tocopherol transfer protein and vitamin E. Proc Natl Acad Sci 2000;97:13830-13834.
12. Munteanu A, Zingg JM, Azzi A. Anti-atherosclerotic effects of vitamin E-myth or reality? J Cell Mol Med 2004; 8:59-76.
13. Drevon CA. Absortion, transport and metabolism of vitamin E. Free Radic Res Commun 1991;14:229-246.
14. Kempnà P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A. Cloning of novel human SEC14p-like proteins: cellular localization, ligand binding and functional properties. Free Rad Biol Med 2003;34:1458-1472.
15. Dutta-Roy AK, Leishman DJ, Gordon MJ, Campbell FM, Duthie GG. Identification of a low molecular mass (14.2 kDa) alpha-tocopherol-binding protein in the cytosol of rat liver and heart. Biochem Biophys Res Commun 1993;196:1108-1112.
16. Simon EJ, Gross CS, Milhorat AT. The metabolism of vitamin E. The absortion and excretion of d-α-tocopheryl-5-methyl-C14-succinate. J Biol Chem 1956;221:797-805.
17. Schultz M, Leist M, Petrzika M, Gassmann B, Brigelius-Flohe R. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2′- carboxyethyl)-6-hydroxychroman as an indicator of an adequate vitamin E supply? Am J Clin Nutr 1995; 62:1527-1534.
18. Ramsey BW, Farell PM, Pencharz P. Committee C. Nutritional assessment and management in cystic fibrosis: a consensus report. Am J Clin Nutr 1992;55:108-116.
19. Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Laina A, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomized placebo-controlled trial. Lancet 2000;356:1213-1218.
20. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomized trial. Lancet 1999;354:810-816.
21. Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ. Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetes complications? Diabetes Care 1991;14:68-72.
22. Paolisso G, D'Amore A, Galzerano D, Balbi V, Gliugliano D, Varricchio M, et al. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Diabetes Care 1993;16:1433-1437.
23. Blot WJ, Li JY, Taylor PR. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combination, cancer incidence and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-1492.
24. Steinberg D. Antioxidants and atherosclerosis: a current assessment. Circulation 1991;84:1420-1425.
25. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-809.
26. Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987:84:2995-2998.
27. Regnstrom J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339:1183-1186.
28. Verlangieri AJ, Bush MU. Effects of d-α-tocopherol supplementation on experimentally induced primate atherosclerosis. J Am Coll Nutr 1992;11:131-138.
29. Pratico D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in apoE-deficient mice. Nat Med 1998; 4:1189-1192.
30. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S. The antioxidant vitamins and cardiovascular disease: a critical review of epidemiological and clinical trial data. Ann Intern Med 1995;123:860-872.
31. Meydani M. Vitamin E. Lancet 1995;345:170-175.
32. Steiner M. Influence of vitamin E on platelet function in humans. J Am Coll Nutr 1991;10:466-473.
33. Bursell SE, King GL. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract 1999;45:169-182.
34. Wu D, Hayek MG, Meydani SN. Vitamin E and macrophage cyclooxygenase regulation in the aged. J Nutr 2001;131:382-388.
35. Susuki YJ, Packer L. Inhibition of NF-kappa B activation by vitamin E derivatives. Biochem Biophys Res Commun 1993;193:277-283.
36. Yoshikawa T, Yoshida N, Manabe H, Terasawa Y, Takemura T, Kondo M. Alpha tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells. Biofactors 1998;7:15-19.
37. De Nigris F, Franconi F, Maida I, Palumbo G, Anania V, Napoli C. Modulation by alpha and gamma-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells. Biochem Pharmacol 2000;59:1477-1487.
38. Azzi A, Gysin R, Kempna P, Ricciarelli R, Villacorta L, Visarius T, et al. Regulation of gene and protein expression by vitamin E. Free Radic Res 2002;36:30-35.
39. Blé-Castillo JL, Carmona-Díaz E, Méndez JD, Larios-Medina FJ, Medina-Santillán R, Cleva-Villanueva G, et al. Effect of a-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics. Biomed Pharmacother 2005;59:290-295.
40. Blé-Castillo JL, Larios-Medina FJ, Medina-Santillán R, Cleva-Villanueva G, Díaz-Zagoya JC, Mendez JD. Effect of alpha-tocopherol on oxidative status and lipid profile in healthy perimenopausal women. Eur J Clin Nutr 2007. Submitted
41. Aguilar-Chánez Cruz L. Efectos de la vitamina E y la pravastatina sobre la lipoperoxidación y el control metabólico de pacientes diabéticos con dislipidemia moderada. Tesis de Maestría en Ciencias Médicas, Universidad Juárez Autónoma de Tabasco, 2004.
42. Council for Responsible Nutrition. Supplement usage patterns of U.S. adults: consumer survey conducted by Ipsos-Reid. Washington, DC: Council for Responsible Nutrition; 2001.
43. Muntwyler J, Hennekens CH, Manson JE, Buring JE, Gaziano JM. Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality. Arch Intern Med 2002;162:1472-1476.
44. Ford ES, Ajan UA, Mokdad AH. Brief communication: the prevalence of high intake of vitamin E from the use of supplements among U.S. adults. Ann Intern Med 2005; 143:116-120.
45. Huang HY, Appel LJ. Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. J Nutr 2003;133:3137-3140.
46. Van Haaften RI, Haenen GR, van Bladeren PJ, Bogaards JJ, Evelo CT, Bast A. Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol. Toxicol In Vitro 2003;17:245-251.
47. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-1035.
48. Bieri JG. Effect of excessive vitamins C and E on vitamin A status. Am J Clin Nutr 1973;26:382-383.
49. Dowd P, Zheng ZB. On the mechanism of the anticlotting action of vitamin E quinone. Proc Natl Acad Sci USA 1995;92:8171-8175.
50. González-Correa JA, Arrebola MM, Guerrero A, Muñoz-Marín J, Ruiz-Villafranca D, Sánchez de la Cuesta F, et al. Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood. Platelets 2005:16:171-179.
51. Boskovic R, Gargaun L, Oren D, Djulus J, Koren G. Pregnancy outcome following high doses of vitamin E supplementation. Reprod Toxicol 2005;20:85-88.
52. Stocker R. The ambivalence of vitamin E in atherogenesis. Trends Biochem Sci 1999;24:219-223.
53. Brown KM, Morrice PC, Duthie GG. Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers. Dose response to vitamin E supplementation. Am J Clin Nutr 1997; 65:496-502.
54. Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ. Pro-oxidant effect of vitamin E in cigarrette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol 2001;21:1029-1033.
55. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004:364:1219-1228.
56. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-1347.
57. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46.
58. Blatt DH, Pryor WA, Jialal I, Devaraj S, Carter T; Baggott JE, et al. High-dosage vitamin E supplementation and all-cause mortality. Ann Intern Med 2005 Jul 19;143:150-155.
59. Jialal I, Devaraj S. Antioxidants and atherosclerosis: don't throw out the baby with the bath water (editorial). Circulation 2003;107:926-928.
60. Jialal I, Devaraj S. Scientific evidence to support a vitamin E and heart disease health claim: research needs. J Nutr 2005;135:348-353.
61. Stephens NG, Parsons A, Schofield PM, et al. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996; 347:781-786.
62. Hatchcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, et al. Vitamin E and C are safe across a broad range of intakes. Am J Clin Nutr 2005;81:736-745.
63. Gillilan RE, Mondell B, Warbasse JR. Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am Heart J 1977;93:444-449.
64. Meydani SN, Meydani M, Blumberg JB. Assesment of the safety of supplementation of different amounts of vitamin E in healthy older adults. Am J Clin Nutr 1998; 63:311-318.
65. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-1347.
66. The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328:176-183.
67. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. A report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Washington, DC: National Academy Press; 2000.
68. Secretaría de Salud. Encuesta Nacional de Nutrición 1999. Estado nutricio de niños y mujeres en México. Disponible en http://www.salud.gob.mx/unidades/cdi/documentos/nutrición.pdf