Acquired immunity: Immunosenescence and physical activity

European Review of Aging and Physical Activity

Volumn 5, Issue 2, 2008, Pages 61-68

  Malaguarnera, Lucia ^b   Cristaldi, Erika ^a   Lipari, Helga ^a   Malaguarnera, Mariano ^a  

^a CANNIZZARO HOSPITAL   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Acquired immunity; Immunosenescence; Na ve T cells; Regular exercise

Indexed keywords

EID: 50949090090     PISSN: 18137253     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11556-008-0039-0     Document Type: Review

References (85)

1. S Aggarwal S Gupta 1998 Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2 and Bax J Immunol 160 1627 1637
2. D Andrew R Aspinall 2002 Age-associated thymic atrophy is linked to a decline in IL-7 production Exp Gerontol 37 455
3. T Bauer B Weisser 2002 Effect of aerobic endurance exercise on immune function in elderly athletes Schweiz Rundsch Med Prax 91 5 153 158
4. Z Bay J Kantorski E Majewska K Zeman L Pokoca E Fornalczyk H Tchòrzewski Z Sulowka R Lewicki 1994 Immunological status of competitive cyclists before and after the training season Int J Sports Med 15 319 324
5. BS Bender JE Nagel WH Adler 1986 Absolute peripheral blood lymphocyte counts and subsequent mortality of elderly man. The Baltimore Longitudinal Study of Aging J Am Geriatr Soc 34 649 654
6. P Beverley 1991 Immunological memory in T cell Curr Opin Immunol 3 355 360
7. C Borghesi C Nicoletti 1994 Increase of cross (auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study Int J Exp Pathol 75 123 130
8. H Bruunsgaard A Hartkopp T Mohr H Konradsen I Heron CH Mordhorst BK Pedersen 1997 In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise Med Sci Sports Exerc 29 1176 1181
9. G Buyukyazi 2004 Differences in the cellular and humoral immune system between sedentary and endurance-trained elderly males Sci Sports 19 130 135
10. LM Castell JR Poortmans R Leclercq M Brasseur J Duchateau EA Newsholme 1997 Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation Eur J Appl Physiol 75 47 53
11. MA Ceddia EA Price CK Kohlmeier JK Evans Q Lu E McAuley JA Woods 1999 Differential leukocytosis and lymphocyte mitogenic response to acute maximal exercise in the young and old Med Sci Sports Exerc 31 6 829 836
12. G Colonna-Romano M Bulati A Aquino G Scialabba G Candore D Lio M Motta M Malaguarnera C Caruso 2003 B-cell in the aged: CD27, CD5 and CD40 expression Mech Ageing Dev 124 389 393
13. GE De Greef GJ Van Staalduinen H Van Doorninck 1992 Age-related changes of the antigen-specific antibody formation in vitro and PHA-induced T-cell proliferation in individuals who met the health criteria of the SENIEUR protocol Mech Ageing Dev 566 1 14
14. Effros RB (2001) Immune system activity. Handbook of the biology of ageing, 5th edn. Academic Press, San Diego
15. A Facchini E Mariani AR Mariani 1987 Increased number of circulating Leu 11+(CD16) large granular lymphocytes and decreased NK activity during human ageing Clin Exp Immunol 68 340 347
16. AG Farr CL Sidman 1984 Reduced expression of Ia antigens by thymic epithelial cells of aged mice J Immunol 133 98
17. MG Flynn M Fahlman WA Braun CP Lambert LE Bouillon PG Brolinson CW Armstrong 1999 Effects of resistance training on selected indexes of immune function in elderly women J Appl Physiol 86 6 1905 1913
18. TM Foy A Aruffo J Bajorath JE Buhlmann RJ Noelle 1996 Immune regulation by CD40 and its ligand GP39 Annu Rev Immunol 14 591 617
19. C Franceschi S Valensis S Fagnoni C Barbi M Bonafe 1999 Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load Exp Gerontol 34 911 921
20. H Geiger G Van Zant 2002 The aging of lympho-hematopoietic stem cells Nat Immunol 3 329 333
21. AJ George MA Ritter 1996 Thymic involution with ageing: obsolescence or good housekeeping? Immunol Today 17 267 272
22. J Gill M Malin J Sutherland D Gray G Hollander R Boyd 2003 Thymic generation and regeneration Immunol Rev 195 28
23. S Gillis R Kozak M Durante ME Weksler 1981 Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans J Clin Invest 67 937 942
24. CD Gimmy GJ Freeman JG Gribben G Gray LM Nadler 1993 Human T-cell clonal anergy is induced by antigen presentation n the absence of B7 costimulation Proc Natl Acad Sci USA 90 6586 590
25. L Ginaldi M De Martinis A D'Ostilio L Marini MF Loreto MP Corsi D Quaglino 1999 The immune system in the elderly: specific humoral immunity Immunol Res 20 101 108
26. H Glathe W Lange 1995 Influenza vaccination in older patients. Immunogenicity, epidemiology and available agents Drugs Aging 6 368 387
27. M Gleeson WA McDonald AW Cripps DB Pyne RL Clancy PA Fricker 1995 The effect on immunity of long-term intensive training in elite swimmers Clin Exp Immunol 102 210 216
28. EA Goidl JB Innes ME Weksler 1976 Immunological studies of aging. II. Loss of Ig and high avidity plaque-forming cells and increased suppressor cell activity in aging mice J Exp Med 144 1037 1048
29. SH Gueldner LW Poon M La Via G Virella Y Michel MH Bramlett CA Noble E Paulling 1997 Long term patterns and immune function in healthy older women. A report of preliminary findings Mech Ageing Dev 93 215 222
30. + T cells in aged humans Exp Gerontol 41 1 69 77
31. B Haynes E Hargen C Olanow G Eisenbarth A Wechsler L Hensley A Roses 1983 Effect of thymectomy on peripheral lymphocyte subsets in myasthenia gravis: selective effect on T-cells in patients with thymic atrophy J Immunol 131 773 777
32. + T cells Immunol Rev 205 220 228
33. A Hu D Ehleiter A Ben-Yeuda 1993 Effect of age on the expressed B cell repertoire: role of B cell subsets Int Immunol 5 1035 1039
34. F Hulstaert I Hannet V Deneys V Munhyeshuli T Reichert M De Bruyere K Strauss 1994 Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements Clin Immunol Immunopathol 70 152 158
35. M Hurme PM Paavilainen M Pertovaara M Jylha PJ Karhunen A Hervonen T Lehtimaki 2005 Ig A levels are predictors of mortality in Finnish nonagenarians Mech Ageing Dev 126 6-7 829 831
36. CA Janeway Jr K Bottanly 1994 Signals and signs for lymphocytes responses Cell 76 275 85
37. I Kang SH Myung H Nolasco SH Park JM Dan J Choi J Craft 2004 Age associated change in the frequency of memory CD 4 T cells impairs long term CD4 T cell responses to influenza vaccine J Immunol 173 673 681
38. ML Kohut MM Cooper MS Nickolaus DR Russell JE Cunnick 2002 Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals J Gerontol A Biol Sci Med Sci 57 M557 M562
39. S Lacroix-Desmazes L Mouthon SV Kaveri MD Kazatchkine ME Weksler 1999 Stability of natural self-reactive antibody repertoire during aging J Clin Immunol 19 26 34
40. G Leone L Mele A Pulsoni F Equitani L Pagano 1999 The incidence of secondary leukemias Haematologica 84 937 945
41. L Li HC Hsu CR Stockard P Yang J Zhou Q Wu WE Grizzle JD Mountz 2004 IL-12 inhibits thymic involution by enhancing IL-7 and IL-2-induced thymocyte proliferation J Immunol 172 2909 2916
42. PS Linsley JA Ledbetter 1993 The role of the CD28 receptor during T cell responses to antigen Ann Rev Immunol 11 191 212
43. BR Ludviksson RO Ehrhardt W Strober 1999 Role of IL-12 in intrathymic negative selection J Immunol 163 4349
44. CR Mackay 1993 Immunological memory Add Immunol 53 217 265
45. L Malaguarnera L Ferlito RM Imbesi GS Gulizia S Di Mauro D Maugeri M Malaguarnera A Messina 2001 Immunosenescence: a review Arch Gerontol Geriatr 31 1 14
46. L Malaguarnera L Ferlito S Di Mauro RM Imbesi G Scalia M Malaguarnera 2001 Immunosenescence and cancer: a review Arch Gerontol Geriatr 32 77 93
47. Malaguarnera L, Cristaldi E, Vinci M, Malaguarnera M (2008) The role of exercise on the innate immunity of the elderly. Eur Rev Aging Phys Act 5:43-49
48. M Malaguarnera A Laurino S Di Mauro M Motta I Di Fazio D Maugeri 2000 The comorbidities of elderly oncologic patients Arch Gerontol Geriatr 30 237 244
49. C Miller G Kelsoe S Hua 1994 Lack of B7-2 expression in the germinal centers of aged mice Age Immunol Infect Desease 5 249 252
50. C Miller G Kelsoe 1995 IgVH hypermutation is absent in the germinal centers of aged mice J immunol 155 3377 3384
51. E Mocchegiani L Santarelli N Fabris 1994 Thymic endocrine function in neuroendocrine human diseases Ann N Y Acad Sci 741 115 123
52. E Mocchegiani R Giacconi C Cipriano E Muti N Gasparini M Malavolta 2004 Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing? Immun Ageing 1 5
53. M Motta L Ferlito L Malaguarnera E Vinci S Bosco D Maugeri M Malaguarnera 2003 Alterations of lymphocytic set-up in elderly patients with cancer Arch Gerontol Geriatr 36 7 14
54. R Moulias A Raynaud-Simon S Moulinas S Meaume 2002 Immunity, autoimmunity and the aging process: complex interaction Ann Med Interne 153 441 445
55. DM Murasko P Weiner D Kaye 1988 Association of lack of mitogen-induced lymphocyte proliferation with increased mortality in the elderly Aging Immunol Infect Dis 1 1 6
56. JE Nagel RK Chopra FJ Chrest MT McCoy EL Schneider NJ Holbrook WH Adler 1988 Decreased proliferation, interleukin-2 synthesis, and interleukin-2 receptor expression are accompanied by mRNA expression in phytohemagglutinin- stimulated cells from elderly donors J Clin Invest 81 1096 1102
57. C Nicoletti 1995 Antibody protection in aging: influence of idiotypic repertoire and antibody binding activity to a bacterial antigen Exp Mol Pathol 62 99 108
58. HB Nielsen BK Pedersen 1997 Lymphocyte proliferation in response to exercise Eur J Appl Physiol 75 375 379
59. DC Nieman LS Berk M Simpson-Westerberg K Arabatzis W Youngberg SA Tan WC Eby 1989 Effects of long endurance running on immune system parameters and lymphocyte function in experienced marathoners Int J Sports Med 10 317 323
60. DC Nieman DA Henson G Gusewitch BJ Warren RC Dotson DE Butterworth SL Nehlsen-Cannarella 1993 Physical activity and immune function in elderly women Med Sci Sports Exerc 25 823 831
61. DC Nieman KS Buckley DA Henson BJ Warren J Suttles JC Ahle S Simandle OR Fagoaga SL Nehlsen-Cannarella 1995 Immune function in marathon runners versus sedentary controls Med Sci Sports Exerc 27 986 992
62. DC Nieman S Simandle DA Henson BJ Warren J Suttles JM Davis KS Buckley JC Ahle DE Butterworth OR Fagoaga SL Nehlsen-Cannarella 1995 Lymphocyte proliferative response to 2.5 hours of running Int J Sports Med 16 404 408
63. T Ohkusu-Tsukada K Isobe 1999 Accelerated development and aging of the immune system in p53-deficient mice J Immunol 163 1966 1972
64. G Pawelec 2003 Immunosenescence in Montecatini Biogerontology 4 121 123
65. G Pawelec A Akbar C Caruso R Solana B Grubeck-Loebenstein A Wikby 2005 Human immunosenescence: is it infectious? Immunol Rev 205 257 268
66. BK Pedersen AD Toft 2000 Effects of exercise on lymphocytes and cytokines Br J Sports Med 34 246 251
67. M Pertovaara A Raitala T Lehtimäki PJ Karhunen SS Oja M Jylha A Hervonen M Hurme 2006 Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality Mech Ageing Dev 127 497 499
68. DC Powers 1994 Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine J Med Virol 43 57 61
69. J Shi RA Miller 1993 Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets J Immunol 151 730 739
70. S Shinkai H Kohno K Kimura T Komura H Asai R Inai K Oka Y Kurokawa R Shephard 1995 Physical activity and immune senescence in men Med Sci Sports Exerc 27 11 1516 26
71. TP Smith SL Kennedy M Fleshner 2004 Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men J Appl Physiol 97 491 498
72. G Steinmann B Klaus H Muller-Hermelink 1985 The involution of aging human thymic epithelium is independent of puberty Scand J Immunol 22 563 575
73. G Steinmann 1986 Changes in the human thymus during aging Curr Top Pathol 75 43 80
74. SL Swain PA Croft C Dubey L Haynes P Rogers X Zhang LM Bradley 1996 From naive to memory T cells Immunol Rev 150 143 167
75. N Tvede J Steensberg B Baslund JH Kristensen BK Pedrsen 1991 Cellular immunity in highly-trained elite racing cyclists and controls during periods of training with high and low intensity Scand J Sports Med 1 163 166
76. W van Ewijk 1991 T-cell differentiation is influenced by thymic microenvironments Annu Rev Immunol 9 591
77. AC Viale JA Chies F Huetz E Malenchere M Weksler AA Freitas A Coutinho 1994 VH-gene family dominance in ageing mice Scand J Immunol 39 184 188
78. K Watanabe K Sato W Biernat O Tachibana K von Ammon N Ogata Y Yonekawa P Kleihues H Ohgaki 1997 Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies Clin Cancer Res 3 4 523 530
79. ME Weksler 2000 Changes in the B-cell repertoire with age Vaccine 18 1624 1628
80. JA Woods MA Ceddia BW Wolters JK Evans Q Lu E McAuley 1999 Effects of 6 months of moderate aerobic exercise training on immune function in the elderly Mech Ageing Dev 109 1 19
81. JA Woods MA Ceddia MD Zack TW Lowder Q Lu 2003 Exercise training increases the naïve to memory T cell ratio in old mice Brain Behav Immun 17 384 392
82. H Yan A Kuroiwa H Tanaka M Shindo A Kiyonaga A Nagayama 2001 Effect of moderate exercise on immune senescence in men Eur J Appl Physiol 86 105 111
83. X Yang J Stedra J Cerny 1994 Repertoire diversity of antibody response to bacterial antigens in aged mice. IV: study of VH and VL gene utilization in specific antibody foci by in situ hybridization J Immunol 152 2214 2221
84. KS Zhao YF Wang R Gueret ME Weksler 1995 Dysregulation of the humoral immune response in old mice Int Immunol 7 929 934
85. T Zhou CK Edwards JD Mountz 1995 Prevention of age-related T cell apoptosis defect in CD2-Fas-transgenic mice J Exp Med 182 129 137