The effect of the ketogenic diet on hippocampal GluR5 and GluR6 mRNA expression and Q/R site editing in the kainate-induced epilepsy model

Epilepsy and Behavior

Volumn 13, Issue 3, 2008, Pages 445-448

  Xu, Xiangping ^a   Sun, Ruopeng ^a   Jin, Ruifeng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Epilepsy; Glutamate receptor; Kainate; Ketogenic diet; RNA editing

Indexed keywords

ANTICONVULSIVE AGENT; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; KAINIC ACID; KAINIC ACID RECEPTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EPILEPSY; GENE EXPRESSION; HIPPOCAMPUS; KETOGENIC DIET; MALE; NONHUMAN; RAT; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; SYNAPTIC TRANSMISSION;

3-HYDROXYBUTYRIC ACID; ANALYSIS OF VARIANCE; ANIMALS; BASE SEQUENCE; BEHAVIOR, ANIMAL; BODY WEIGHT; DISEASE MODELS, ANIMAL; EPILEPSY; GENE EXPRESSION; HIPPOCAMPUS; KAINIC ACID; KETOGENIC DIET; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, KAINIC ACID; RNA EDITING; RNA, MESSENGER;

EID: 50849106387     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2008.05.020     Document Type: Article

References (26)

1. Hartman A.L., and Vining E.P. Clinical aspects of the ketogenic diet. Epilepsia 48 (2007) 31-42
2. Rodriguez-Moreno A., Herreras O., and Lerma J. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19 (1997) 893-901
3. Castillo P.E., Malenka R.C., and Nicoll R.A. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388 (1997) 182-186
4. Sommer B., Kohler M., Sprengel R., and Seeburg P.H. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67 (1991) 11-19
5. Lerma J. Kainate receptor physiology. Curr Opin Pharmacol 6 (2006) 89-97
6. Ullal G., Fahnestock M., and Racine R. Time-dependent effect of kainate-induced seizures on glutamate receptor GluR5, GluR6, and GluR7 mRNA and protein expression in rat hippocampus. Epilepsia 46 (2005) 616-623
7. Bernard A., Ferhat L., Dessi F., et al. Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation. Eur J Neurosci 11 (1999) 604-616
8. Mathern G.W., Pretorius J.K., Kornblum H.I., et al. Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiol Dis 5 (1998) 151-176
9. Kortenbruck G., Berger E., Speckmann E.J., and Musshoff U. RNA editing at the Q/R site for the glutamate receptor subunits GLUR2, GLUR5, and GLUR6 in hippocampus and temporal cortex from epileptic patients. Neurobiol Dis 8 (2001) 459-468
10. Wilding T.J., Chai Y.H., and Huettner J.E. Inhibition of rat neuronal kainate receptors by cis-unsaturated fatty acids. J Physiol 513 Pt. 2 (1998) 331-339
11. Wilding T.J., Zhou Y., and Huettner J.E. Q/R site editing controls kainate receptor inhibition by membrane fatty acids. J Neurosci 25 (2005) 9470-9478
12. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32 (1972) 281-294
13. Bernard A., and Khrestchatisky M. Assessing the extent of RNA editing in the TMII regions of GluR5 and GluR6 kainate receptors during rat brain development. J Neurochem 62 (1994) 2057-2060
14. Belcher S.M., and Howe J.R. Characterization of RNA editing of the glutamate-receptor subunits GluR5 and GluR6 in granule cells during cerebellar development. Brain Res Mol Brain Res 52 (1997) 130-138
15. Bough K.J., Valiyil R., Han F.T., and Eagles D.A. Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res 35 (1999) 21-28
16. Muller-Schwarze A.B., Tandon P., Liu Z., Yang Y., Holmes G.L., and Stafstrom C.E. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. NeuroReport 10 (1999) 1517-1522
17. Freeman J.M., Freeman J.B., and Kelly M.T. The epilepsy diet treatment (1999), Demos, New York
18. Mulle C., Sailer A., Perez-Otano I., et al. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 392 (1998) 601-605
19. Bortolotto Z.A., Clarke V.R., Delany C.M., et al. Kainate receptors are involved in synaptic plasticity. Nature 402 (1999) 297-301
20. Contractor A., Swanson G.T., Sailer A., O'Gorman S., and Heinemann S.F. Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J Neurosci 20 (2000) 8269-8278
21. Telfeian A.E., Federoff H.J., Leone P., During M.J., and Williamson A. Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro. Neurobiol Dis 7 (2000) 362-374
22. McNamara J.O. Emerging insights into the genesis of epilepsy. Nature 399 (1999) A15-A22
23. Swanson G.T., Feldmeyer D., Kaneda M., and Cull-Candy S.G. Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors. J Physiol 492 Pt. 1 (1996) 129-142
24. Bowie D., and Mayer M.L. Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block. Neuron 15 (1995) 453-462
25. Vissel B., Royle G.A., Christie B.R., et al. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29 (2001) 217-227
26. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 10 (1993) 491-500