Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses

Cancer Immunology, Immunotherapy

Volumn 57, Issue 11, 2008, Pages 1657-1664

  Gao, Jian Qing ^a   Kanagawa, Naoko ^b   Xu, Dong Hang ^a   Han, Min ^a   Sugita, Toshiki ^b   Hatanaka, Yutaka ^c   Tani, Yoichi ^c   Mizuguchi, Hiroyuki ^d   Tsutsumi, Yasuo ^d   Mayumi, Tadanori ^e   Okada, Naoki ^b   Nakagawa, Shinsaku ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b OSAKA UNIVERSITY   (Japan)

^c Dako Japan Co Ltd   (Japan)

^d NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^e KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Adenovirus vector; Anti tumor activity; Chemokine FKN; Immunotherapy; Interleukin 12; Tumor infiltrating immune cell

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; CD3 ANTIGEN; CHEMOKINE FKN; INTERLEUKIN 12; PERFORIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL INFILTRATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; RGD FIBER MUTANT ADENOVIRUS; TREATMENT FAILURE; TUMOR IMMUNITY; TUMOR REGRESSION; TUMOR REJECTION; VIRUS MUTANT;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG THERAPY, COMBINATION; FEMALE; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; INTERFERON TYPE II; INTERLEUKIN-11 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-12; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; OLIGOPEPTIDES; OVARIAN NEOPLASMS;

EID: 50649107268     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0499-0     Document Type: Article

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