Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 8, 2008, Pages 2243-2246

  Kunimasa, Kazuhiro ^a   Kobayashi, Tomomi ^a   Sugiyama, Sayuri ^a   Kaji, Kazuhiko ^a   Ohta, Toshiro ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Angiogenesis; Apoptosis; Endothelial cell; Indole 3 carbinol; Tube formation

Indexed keywords

BLOOD VESSEL PROSTHESES; CELL DEATH; METHANOL; SELF ASSEMBLY; TUBES (COMPONENTS); TUMORS;

ANGIOGENESIS; APOPTOSIS; ENDOTHELIAL CELL; INDOLE-3-CARBINOL; TUBE FORMATION;

ENDOTHELIAL CELLS;

3 INDOLEMETHANOL; CASPASE; INDOLE DERIVATIVE; INDOLE-3-CARBINOL;

AIR SAC; ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; MOUSE; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; VASCULARIZATION;

AIR SACS; ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; INDOLES; MICE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 50649088963     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80292     Document Type: Article

References (14)

1. Verhoeven, D. T., Verhagen, H., Goldbohm, R. A., van den Brandt, P. A., and van Poppel, G., A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem. Biol. Interact., 103, 79-129 (1997).
2. Folkman, J., Clinical applications of research on angiogenesis. N. Engl. J. Med., 333, 1757-1763 (1995).
3. Folkman, J., Angiogenesis and apoptosis. Semin. Cancer Biol., 13, 159-167 (2003).
4. Cohen, G. M., Caspases: the executioners of apoptosis. Biochem. J., 326, 1-16 (1997).
5. Ahn, M.-R., Kunimasa, K., Ohta, T., Kumazawa, S., Kamihira, M., Kaji, K., Uto, Y., Hori, H., Nagasawa, H., and Nakayama, T., Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett., 252, 235-243 (2007).
6. Chen, W., Suruga, K., Nishimura, N., Gouda, T., Lam, V. N., and Yokogoshi, H., Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats. Life Sci., 77, 746-757 (2005).
7. Ohta, T., Eguchi, R., Suzuki, A., Miyakaze, S., Ayuzawa, R., and Kaji, K., Hypoxia-induced apoptosis and tube breakdown are regulated by p38 MAPK but not by caspase cascade in an in vitro capillary model composed of human endothelial cells. J. Cell. Physiol., 211, 673-681 (2007).
8. Souli, E., Machluf, M., Morgenstern, A., Sabo, E., and Yannai, S., Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem. Toxicol., 46, 863-870 (2008).
9. Anderton, M. J., Manson, M. M., Verschoyle, R. D., Gescher, A., Lamb, J. H., Farmer, P. B., Steward, W. P., and Williams, M. L., Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin. Cancer Res., 10, 5233-5241 (2004).
10. Wu, H.-T., Lin, S.-H., and Chen, Y.-H., Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables. J. Agric. Food Chem., 53, 5164-5169 (2005).
11. Weng, J.-R., Tsai, C.-H., Kulp, S. K., Wang, D., Lin, C.-H., Yang, H.-C., Ma, Y., Sargeant, A., Chiu, C.-F., Tsai, M.-H., and Chen, C.-S., A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. Cancer Res., 67, 7815-7824 (2007).
12. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., and Davis, G. E., Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci., 114, 2755-2773 (2001).
13. Morris, P. B., Hida, T., Blackshear, P. J., Klintworth, G. K., and Swain, J. L., Tumor-promoting phorbol esters induce angiogenesis in vivo. Am. J. Physiol., 254, 318-322 (1988).
14. Chang, X., Tou, J. C., Hong, C., Kim, H.-A., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F., 3,3′-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis, 26, 771-778 (2005).