Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector

Journal of General Virology

Volumn 89, Issue 8, 2008, Pages 1819-1828

  Lucifora, J ^a,b   Durantel, D ^a,b,c   Belloni, L ^a,d   Barraud, L ^d   Villet, S ^a,b   Vincent, I E ^a,b   Margeridon Thermet, S ^a,b   Hantz, O ^a,b   Kay, A ^a,b   Levrero, M ^a,e   Zoulim, F ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c HÔTEL DIEU   (France)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e Eurofins Medinet Inc   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; BACULOVIRUS VECTOR; CIRCULAR DNA; HISTONE; LAMIVUDINE; VIRUS DNA;

ANTIVIRAL RESISTANCE; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CELL DIFFERENTIATION; CELL NUCLEUS; CELL STRAIN HEPG2; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DETERMINATION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SUPERNATANT; VIRAL GENETICS; VIRUS GENOME; VIRUS MUTANT; VIRUS MUTATION; VIRUS NUCLEOCAPSID; VIRUS PARTICLE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; BACULOVIRUS; DNA REPLICATION; EVALUATION; GENE VECTOR; GENETIC RECOMBINATION; GENETICS; LIVER CELL; METABOLISM; METHODOLOGY; PATHOGENICITY; PHYSIOLOGY; TUMOR CELL LINE; VIRION; VIROLOGY;

HEPATITIS B VIRUS; MAMMALIA;

BACULOVIRIDAE; CELL LINE, TUMOR; DNA REPLICATION; GENETIC VECTORS; GENOME, VIRAL; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; RECOMBINATION, GENETIC; TRANSDUCTION, GENETIC; VIRION; VIROLOGY; VIRUS REPLICATION;

EID: 50549104600     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83659-0     Document Type: Article

References (34)

1. Allen, M. I., Deslauriers, M., Andrews, C. W., Tipples, G. A., Walters, K. A., Tyrrell, D. L., Brown, N. & Condreay, L. D. (1998). Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. Hepatology 27, 1670-1677.
2. Back, C. T., Schwinn, S., Locarnini, S., Fyfe, J., Manns, M. P., Trautwein, C. & Zentgraf, H. (2001). Structural organization of the hepatitis B virus minichromosome. J Mol Biol 307, 183-196.
3. Brunelle, M. N., Jacquard, A. C., Pichoud, C., Durantel, D., Carrouee-Durantel, S., Villeneuve, J. P., Trepo, C. & Zoulim, F. (2005). Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir. Hepatology 41, 1391-1398.
4. Delaney, W. E., IV & Isom, H. C. (1998). Hepatitis B virus replication in human HepG2 cells mediated by hepatitis B virus recombinant baculovirus. Hepatology 28, 1134-1146.
5. Delaney, W. E., IV, Miller, T. G. & Isom, H. C. (1999). Use of the hepatitis B virus recombinant baculovirus-HepG2 system to study the effects of (-)-β-2′,3′-dideoxy-3′-thiacytidine on replication of hepatitis B virus and accumulation of covalently closed circular DNA. Antimicrob Agents Chemother 43, 2017-2026.
6. Delaney, W. E., IV, Yang, H., Westland, C. E., Das, K., Arnold, E, Gibbs, C. S., Miller, M. D. & Xiong, S. (2003). The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J Virol 77, 11833-11841.
7. Durantel, D., Carrouee-Durantel, S., Werle-Lapostolle, B., Brunelle, M. N., Pichoud, C., Trepo, C. & Zoulim, F. (2004). A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus. Hepatology 40, 855-864.
8. Durantel, D., Brunelle, M. N., Gros, E., Carrouee-Durantel, S., Pichoud, C., Villet, S., Trepo, C. & Zoulim, F. (2005). Resistance of human hepatitis B virus to reverse transcriptase inhibitors: from genotypic to phenotypic testing. J Clin Virol 34 (Suppl. 1), S34-S43.
9. Ganem, D. (1991). Assembly of hepadnaviral virions and subviral particles. Curr Top Microbiol Immunol 168, 61-83.
10. Gripon, P., Diot C., Theze, N., Fourel, L., Loreal, O., Brechot C. & Guguen-Guillouzo, C. (1988). Hepatitis B virus infection of adult human hepatocytes cultured in the presence of dimethyl sulfoxide. J Virol 62, 4136-4143.
11. Gripon, P., Rumin, S., Urban, S., Le Seyec, J., Glaise, D., Cannie, I., Guyomard, C., Lucas, J., Trepo, C. & Guguen-Guillouzo, C. (2002). Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A 99, 15655-15660.
12. Karayiannis, P. (2003). Hepatitis B virus: old, new and future approaches to antiviral treatment. J Antimicrob Chemother 51, 761-785.
13. King, L. A. & Possee, R. D. (1992). The Baculovirus Expression System: a Laboratory Guide. London: Chapman & Hall.
14. Lasken, R. S. & Egholm, M. (2003). Whole genome amplification: abundant supplies of DNA from precious samples or clinical specimens. Trends Biotechnol 21, 531-535.
15. Lau, D. T., Khokhar, M. F., Doo, E., Ghany, M. G., Herion, D., Park, Y., Kleiner, D. E., Schmid, P., Condreay, L. D. & other authors (2000). Long-term therapy of chronic hepatitis B with lamivudine. Hepatology 32, 828-834.
16. Marcellin, P., Chang, T. T., Lim, S. G., Tong, M. J., Sievert, W., Shiffman, M. L., Jeffers, L., Goodman, Z., Wulfsohn, M. S. & other authors (2003). Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med 348, 808-816.
17. Margeridon, S., Durantel, S., Chemin, I., Barraud, L., Zoulim, F., Trépo, C. & Kay, A. (2006). Rolling circle amplification technology for the study of HBV variants. J Clin Virol 36, S51-S52.
18. Newbold, J. E., Xin, H., Tencza, M., Sherman, G., Dean, J., Bowden, S. & Locarnini, S. (1995). The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. J Virol 69, 3350-3357.
19. Peters, M. G., Hann Hw, H., Martin, P., Heathcote, E. J., Buggisch, P., Rubin, R., Bourliere, M., Kowdley, K., Trepo, C. & other authors (2004). Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology 126, 91-101.
20. Pollicino, T., Belloni, L., Raffa, G., Pediconi, N., Squadrito, G., Raimondo, G. & Levrero, M. (2006). Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histories. Gastroenterology 130, 823-837.
21. Qi, X., Xiong, S., Yang, H., Miller, M. & Delaney, W. E., 4th (2007). In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents. Antivir Ther 12, 355-362.
22. Ren, S. & Nassal, M. (2001). Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors. J Virol 75, 1104-1116.
23. Seeger, C. & Mason, W. S. (2000). Hepatitis B virus biology. Microbiol Mol Biol Rev 64, 51-68.
24. Seigneres, B., Pichoud, C., Martin, P., Furman, P., Trepo, C. & Zoulim, F. (2002). Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. Hepatology 36, 710-722.
25. Sells, M. A., Chen, M. L. & Acs, G. (1987). Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci U S A 84, 1005-1009.
26. Summers, J., Smith, P. M. & Horwich, A. L. (1990). Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. J Virol 64, 2819-2824.
27. Sun, D. & Nassal, M. (2006). Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus. J Hepatol 45, 636-645.
28. Tuttleman, J. S., Pourcel, C. & Summers, J. (1986). Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 47, 451-460.
29. Villeneuve, J. P., Durantel, D., Durantel, S., Westland, C., Xiong, S., Brosgart, C. L., Gibbs, C. S., Parvaz, P., Werle, B. & other authors (2003). Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol 39, 1085-1089.
30. Villet, S., Pichoud, C., Villeneuve, J. P., Trepo, C. & Zoulim, F. (2006). Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient. Gastroenterology 131, 1253-1261.
31. Villet, S., Ollivet A., Pichoud, C., Barraud, L., Villeneuve, J. P., Trepo, C. & Zoulim, F. (2007). Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. J Hepatol 46, 531-538.
32. Werle-Lapostolle, B., Bowden, S., Locarnini, S., Wursthorn, K., Petersen, J., Lau, G., Trepo, C., Marcellin, P., Goodman, Z. & other authors (2004). Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126, 1750-1758.
33. Zhu, Y., Yamamoto, T., Cullen, J., Saputelli, J., Aldrich, C. E., Miller, D. S., Litwin, S., Furman, P. A., Jilbert, A. R. & Mason, W. S. (2001). Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol 73, 311-322.
34. Zoulim, F. (2004). Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection. Antiviral Res 64, 1-15.