Synthesis and regioselective N- and O-alkylation of 3-alkyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones and 2-phenyl-9-propyl-9H-purin-6(1H)-one with evaluation of antiviral and antitumor activities

Tetrahedron

Volumn 64, Issue 42, 2008, Pages 9885-9894

  Islam, Rafiqul ^a   Ashida, Noriyuki ^b   Nagamatsu, Tomohisa ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

Author keywords

Antitumor activity; Antiviral activity; Regioselective alkylation; Synthesis; Triazolopyrimidinone

Indexed keywords

2 PHENYL 9 PROPYL 9H PURIN 6(1H) ONE; 3 (2 HYDROXYETHYL) 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (2 HYDROXYETHYL) 6 METHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (2 HYDROXYETHYL) 7 METHOXY 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 3 (3 HYDROXYPROPYL) 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (3 HYDROXYPROPYL) 6 METHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (3 HYDROXYPROPYL) 7 METHOXY 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 3 ETHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ETHYL 6 METHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ETHYL 7 METHOXY 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 3 ISOBUTYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ISOBUTYL 6 METHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ISOBUTYL 7 METHOXY 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 3 ISOPROPYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ISOPROPYL 6 METHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 ISOPROPYL 7 METHOXY 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 3 OCTYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 5 PHENYL 3 PROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 6 METHYL 3 OCTYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 6 METHYL 5 PHENYL 3 PROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 7 CHLORO 3 (2 CHLOROETHYL) 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 CHLORO 3 ISOBUTYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 CHLORO 3 ISOPROPYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 CHLORO 5 ETHYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 CHLORO 5 PHENYL 5 PROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 METHOXY 3 OCTYL 5 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; 7 METHOXY 5 PHENYL 3 PROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALKYLATION; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOUTH CARCINOMA; PRIORITY JOURNAL;

EID: 50549100940     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.08.014     Document Type: Article

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