Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 922-940

  Ali, Hamed I ^a   Ashida, Noriyuki ^b   Nagamatsu, Tomohisa ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

Author keywords

Alloxazine 5 oxide; Antitumor activity; AutoDock; Flavin 5 oxide

Indexed keywords

10 ETHYL 2 ISOBUTYLAMINO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 ETHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 ETHYL 7 METHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 ETHYLBENZO[G]PTERIDINE 2,4 (3H,10H)DIONE; 10 METHYL 2 METHYLAMINO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 METHYL 2 METHYLAMINOPYRIMIDO[4,5 B]QUINOLIN 4(10H)ONE; 10 METHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 METHYL 2 OCTYLAMINO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 10 METHYL 2 OCTYLAMINOPYRIMIDO[4,5 B]QUINOLIN 4 (10H)ONE; 10 METHYLBENZO[G]PTERIDINE 2,4(3H,10H)DIONE; 2 (2 HYDROXYETHYLAMINO) 7,10 DIMETHYL 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 2 BENZYLAMINO 7 CHLORO 10 METHYL 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 2 CYCLOHEXYLAMINO 7,10 DIMETHYL 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 2 METHYLTHIO 4 OXO 3,4 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 2 METHYLTHIOPYRIMIDO[4,5 B]QUINOLIN 4 (3H)ONE; 7 CHLORO 10 METHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7 METHOXY 10 METHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7 METHOXY 10 METHYL 2 PIPERIDINO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7 METHOXY 10 METHYL 2,4 DIOXO 2,3,4,10 TETRAHYDROBENZO[G]PTERIDINE 5 OXIDE; 7 METHOXY 2 METHYLTHIO 4 OXO 3,4 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7,10 DIMETHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7,8,10 TRIMETHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7,9 DIMETHYL 2 METHYLTHIO 4 OXO 3,4 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 7,9 DIMETHYL 2 METHYLTHIOPYRIMIDO[4,5 B]QUINOLIN 4 (3H)ONE; 8 METHOXY 10 METHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; 9,10 DIMETHYL 2 METHYLTHIO 4 OXO 4,10 DIHYDROBENZO[G]PTERIDINE 5 OXIDE; ANTINEOPLASTIC AGENT; CYTARABINE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; NITROSATION; PHARMACODYNAMICS; STEREOSPECIFICITY; SUBSTITUTION REACTION; TUMOR CELL CULTURE; VILSMEIER HAACK REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVINS; HUMANS; INHIBITORY CONCENTRATION 50; KB CELLS; MOLECULAR STRUCTURE; OXAZINES; OXIDES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38549125634     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.014     Document Type: Article

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