Synthesis and regioselective N- and O-alkylation of 1H- or 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones (8-azaxanthines) and transformation of their 3-alkyl derivatives into 1-alkyl isomers

Synthesis

Volumn , Issue 24, 2006, Pages 4167-4179

  Islam, Rafiqul ^a   Nagamatsu, Tomohisa ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

8 azaxanthines; Alkylations; Heterocycles; Regioselectivity; Triazolopyrimidines

Indexed keywords

ALKYLATIONS; HETEROCYCLES; REGIOSELECTIVITY; TRIAZOLOPYRIMIDINES;

DERIVATIVES; HIGH TEMPERATURE EFFECTS; ISOMERS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

KETONES;

1H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7(4H,6H) DIONE DERIVATIVE; 2H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7(4H,6H) DIONE DERIVATIVE; 3 2 TOLYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 3 TOLYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 BENZYL 6 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 BUTYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 CYCLOHEXYL 6 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 CYCLOPENTYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 CYCLOPENTYL 6 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 HEPTYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 ISOBUTYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 ISOBUTYL 6 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 ISOPROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 ISOPROPYL 6 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 OCTYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 PHENETHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3 PROPYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3,6 DIMETHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7(4H,6H) DIONE DERIVATIVE; 4 METHYL 1H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 4,6 DIMETHYL 1H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 1H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 3 2 TOLYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 3 3 TOLYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 3 4 TOLYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 3 PHENETHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; 6 METHYL 6 PHENYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDINE 5,7[4H,6H] DIONE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ISOMER; METHYLATION; ROOM TEMPERATURE;

EID: 33846010753     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-950337     Document Type: Article

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