Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways

Food and Chemical Toxicology

Volumn 46, Issue 9, 2008, Pages 3122-3131

  Wojcikowski, Ken ^a,b   Wohlmuth, Hans ^b   Johnson, David W ^a   Gobe, Glenda ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b SOUTHERN CROSS UNIVERSITY   (Australia)

Author keywords

Dioscorea villosa; Herbal; Pro fibrotic; Renal fibrosis; Toxicity; Wild yam

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; DIOSCOREA VILLOSA EXTRACT; DYE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MASSON TRICHROME; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; DISEASE MODEL; EPITHELIUM CELL; EXTRACTION; FIBROBLAST; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY FIBROSIS; KIDNEY INJURY; LIVER; MACROPHAGE; MALE; MESENCHYME CELL; MICROSCOPY; MORPHOMETRICS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RHIZOME; SPRAGUE DAWLEY RAT; STAINING; WESTERN BLOTTING; YAM;

ANIMALS; BLOTTING, WESTERN; CHRONIC DISEASE; CYTOKINES; DIOSCOREA; FIBROBLASTS; FIBROSIS; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY DISEASES; LIVER; MACROPHAGES; MALE; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; DIOSCOREA VILLOSA; RATTUS;

EID: 50549093854     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.06.090     Document Type: Article

References (38)

1. Adverse Drug Reaction Unit, Therapeutic Goods Administration (TGA), Australia, 11 April 2008.
2. Anonymous. Final report of the amended safety assessment of Dioscorea villosa (wild yam) root extract. Int. J. Toxicol. 23 (2004) 49-54
3. Bhandari M.R., and Kawabata J. Bitterness and toxicity in wild yam (Dioscorea spp.) tubers of Nepal. Plant Foods Hum. Nutr. 60 (2005) 129-135
4. Blowey D.L. Nephrotoxicity of over-the-counter analgesics, natural medicines, and illicit drugs. Adolesc. Med. Clin. 16 (2005) 31-43
5. Bottinger E.P. TGF-(beta) in renal injury and disease. Semin. Nephrol. 27 (2007) 309-320
6. Braun L., and Cohen M. Herbs and Natural Supplements - An Evidence-Based Guide. second ed. (2007), Elsevier, Churchill Livingstone (p. 692)
7. Carroll D.G. Nonhormonal therapies for hot flashes in menopause. Am. Fam. Physician 73 (2006) 457-464
8. Chang S.-J., Lee Y.-C., Liu S.-Y., and Chang T.-W. Chinese yam (Dioscorea alata cv Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats. J. Agric. Food Chem. 52 (2004) 1720-1725
9. Choi E.-M., and Hwang J.-K. Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage. Fitoterapia 73 (2002) 629-637
10. Costa J., Crausman R.S., and Weinberg M.S. Acute and chronic renal failure. J. Am. Podiatric Med. Assoc. 94 (2004) 168-176
11. Elseviers M.M., and De Broe M.E. Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?. Drug Safety 20 (1999) 15-24
12. Fujigaki Y., Muranaka Y., Sun D., Goto T., Zhou H., and Sakakima M. Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats. Virchows Arch. 446 (2005) 164-176
13. Gonlusen G., Ergin M., Paydas S., and Tunali N. The expression of cytoskeletal proteins (alpha-SMA, vimentin, desmin) in kidney tissue: a comparison of fetal, normal kidneys, and glomerulonephritis. Int. Urol. Nephrol. 33 (2001) 299-305
14. Groma V. Demonstration of collagen type VI and alpha-smooth muscle actin in renal fibrotic injury in man. Nephrol. Dial. Transplant. 13 (1998) 305-312
15. Gurujeyalakshmi G., Wang Y., and Giri S.N. Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice. J. Pharmacol. Exp. Ther. 293 (2000) 82-90
16. Jiang S.H., Liu C.F., Zhang X.L., Xu X.H., Zou J.Z., and Fang Y. Renal protection by delayed ischaemic preconditioning is associated with inhibition of the inflammatory response and NF-kappaB activation. Cell Biochem. Funct. 25 (2007) 335-343
17. Klahr S., and Morrissey J.J. The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease. Kidney Int. Suppl. 75 (2000) 7-14
18. Lee F.T.H., Cao Z., Long D.M., Panagiotopoulos S., Jerums G., and Cooper M.E. Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. J. Am. Soc. Nephrol. 15 (2004) 2139-2151
19. Lee S.C., Tsai C.C., Chen J.C., Lin J.G., Lin C.C., and Hu M.L. Effects of Chinese yam on hepato-nephrotoxicity of acetaminophen in rats. Acta Pharmacol. Sin. 23 (2002) 503-508
20. Lin H.Z., Yang S.Q., Zeldin G., and Diehl A.M. Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. Alcoholism: Clin. Exp. Res. 22 (1998) 231S-237S
21. Liu B.-C., Zhang J.-D., Zhang X.-L., Wu G.-Q., and Li M.-X. Role of connective tissue growth factor (CTGF) module 4 in regulating epithelial mesenchymal transition (EMT) in HK-2 cells. Clin. Chim. Acta 373 (2006) 144-150
22. Liu Y.-W., Shang H.-F., Wang C.-K., Hsu F.-L., and Hou W.-C. Immunomodulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv Tainong No. 1) tuber. Food Chem. Toxicol. 45 (2007) 2312-2318
23. Ng Y.Y., Huang T.P., Yang W.C., Chen Z.P., Yang A.H., and Mu W. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int. 54 (1998) 864-876
24. Pat B., Hughson M.B., Nicol J., Hoy W.E., and Gobe G.C. A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites. Virchows Archiv. 450 (2007) 41-50
25. Prud'homme G.J. Pathobiology of transforming growth factor (beta) in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 87 (2007) 1077-1091
26. Qi W., Chen X., Polhill T.S., Sumual S., Twigg S., and Gilbert R.E. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. Am. J. Physiol. Renal Physiol. 290 (2006) 703-709
27. Soffa V.M. Alternatives to hormone replacement for menopause. Altern. Ther. Health Med. 2 (1996) 34-39
28. Su L., Zhu J.H., and Cheng L.B. Experimental pathological study of subacute intoxication by Dioscorea bulbifera L. Fa yi xue za zhi 19 (2003) 81-83
29. Tato C.M., and Hunter C.A. Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. Infect. Immun. 70 (2002) 3311-3317
30. Vielhauer V., and Mayadas T.N. Functions of TNF and its receptors in renal disease: distinct roles in inflammatory tissue injury and immune regulation. Semin. Nephrol. 27 (2007) 286-308
31. Villanueva S., Cespedes C., and Vio C.P. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am. J. Physiol. Reg. Integr. Comp. Physiol. 290 (2006) R861-R870
32. Wang W., Koka V., and Lan H.Y. Transforming growth factor-(beta) and Smad signalling in kidney diseases. Nephrology 10 (2005) 48-56
33. Wojcikowski K., Gobe G., and Johnson D. Medicinal herbal extracts-renal friend or foe? Part 1: Toxicity. Nephrology 9 (2004) 313-318
34. Wojcikowski K., Johnson D.W., and Gobe G. Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies. J. Lab. Clin. Med. 147 (2006) 160-166
35. Wojcikowski, K., Wohlmuth, H., Johnson, D.W., Rolfe, M., Gobe, G., 2008. An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: Potential therapeutic and toxic effects. Nephrology (in press).
36. Yazawa K., Isaka Y., Takahara S., Imai E., Ichimaru N., and Shi Y. Direct transfer of hepatocyte growth factor gene into kidney suppresses cyclosporin A nephrotoxicity in rats. Nephrol. Dial. Transplant. 19 (2004) 812-816
37. Yu H.T. Progression of chronic renal failure. Arch. Intern. Med. 163 (2003) 1417-1429
38. Zhang C., Meng X., Zhu Z., Liu J., and Deng A. Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro. Cell Biol. Int. 28 (2004) 863-873