Protective immunity against porcine circovirus 2 by vaccination with ORF2-based DNA and subunit vaccines in mice

Journal of General Virology

Volumn 89, Issue 8, 2008, Pages 1857-1865

  Shen, Hui Gang ^a,b   Zhou, Ji Yong ^a,b   Huang, Zhen Yu ^a   Guo, Jun Qing ^a,b   Xing, Gang ^a   He, Jia Ling ^a   Yan, Yan ^a,b   Gong, Li Yang ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; NEUTRALIZING ANTIBODY; SUBUNIT VACCINE; VIRUS DNA; VIRUS VACCINE; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CIRCOVIRIDAE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG EFFICACY; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; VACCINATION; VIREMIA; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS NEUTRALIZATION; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL LINE; CLASSIFICATION; FEMALE; GENETICS; IMMUNOLOGY; PATHOLOGY; SERODIAGNOSIS; VIROLOGY;

MIRIDAE; MUS; PORCINE CIRCOVIRUS 2;

ANIMALS; ANTIBODIES, VIRAL; CAPSID PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; DNA, VIRAL; FEMALE; FLOW CYTOMETRY; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; OPEN READING FRAMES; PLASMIDS; VACCINATION; VACCINES, DNA; VACCINES, SUBUNIT; VIREMIA;

EID: 50549090178     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.2008/000125-0     Document Type: Article

References (57)

1. Abbas, A. K., Murphy, K. M. & Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
2. Allan, G. M. & Ellis, J. A. (2000). Porcine circoviruses: a review. J Vet Diagn Invest 12, 3-14.
3. Allan, G., Meehan, B., Todd, D., Kennedy, S., McNeilly, F., Ellis, J., Clark E. G., Harding, J., Espuna, E. & other authors (1998a). Novel porcine circoviruses from pigs with wasting disease syndromes. Vet Rec 142, 467-468.
4. Allan, G. M., McNeilly, F., Kennedy, S., Daft, B., Clarke, E. G., Ellis, J. A., Haines, D. M., Meehan, B. M. & Adair, B. M. (1998b). Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J Vet Diagn Invest 10, 3-10.
5. Blanchard, P., Mahe, D., Cariolet R., Keranflec'h, A., Baudouard, M. A., Cordioli, P., Albina, E. & Jestin, A. (2003). Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins. Vaccine 21, 4565-4575.
6. Carasova, P., Celer, V., Takacova, K., Trundova, M., Molinkova, D., Lobova, D. & Smola, J. (2007). The levels of PCV2 specific antibodies and viremia in pigs. Res Vet Sci 83, 274-278.
7. Chianini, F., Majo, N., Segales, J., Dominguez, J. & Domingo, M. (2003). Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 94, 63-75.
8. Clark E. G. (1997). Post-weaning multisystemic wasting syndrome. Proc Am Assoc Swine Pract 28, 499-501.
9. Del Prete, G. (1998). The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int Rev Immunol 16, 427-455.
10. + cell-, interferon gamma-, and nitric oxide-dependent immunity. J Exp Med 183, 1739-1746.
11. Ellis, J., Hassard, L., Clark, E., Harding, J., Allan, G., Willson, P., Strokappe, J., Martin, K., McNeilly, F. & other authors (1998). Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J 39, 44-51.
12. Fan, H., Xiao, S., Tong, T., Wang, S., Xie, L., Jiang, Y., Chen, H. & Fang, L. (2008). Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments. Mol Immunol 45, 653-660.
13. Fenaux, M., Halbur, P. G., Haqshenas, G., Royer, R., Thomas, P., Nawagitgul, P., Gill, M., Toth, T. E. & Meng, X. J. (2002). Cloned genomic DNA of type 2 porcine circovirus is infectious wrien injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, virus distribution, and pathologic lesions. J Virol 76, 541-551.
14. Fenaux, M., Opriessnig, T., Halbur, P. G. & Meng, X. J. (2003). Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs. J Virol 77, 11232-11243.
15. Fenaux, M., Opriessnig, T., Halbur, P. G., Elvinger, F. & Meng, X. J. (2004). A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. J Virol 78, 6297-6303.
16. Gilpin, D. F., McCullough, K., Meehan, B. M., McNeilly, F., McNair, I., Stevenson. L. S.. Foster. J. C.. Ellis. J. A.. Krakowka. S. & other authors (2003). In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Vet Immunol Immunopathol 94, 149-161.
17. Hamel, A. L., Lin, L. L. & Nayar, G. P. (1998). Nucleoticle sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs. J Virol 72, 5262-5267.
18. Hasslung, F. C., Berg, M., Allan, G. M., Meehan, B. M., McNeilly, F. & Fossum, C. (2003). Identification of a sequence from the genome of porcine circovirus type 2 with an inhibitory effect on IFN-α production by porcine PBMCs. J Gen Virol 84, 2937-2945.
19. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H. & other authors (2000). A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
20. Hirai, T., Nunoya, T., Ihara, T., Saitoh, T., Shibuya, K. & Nakamura, K. (2006). Infectivity of porcine circovirus 1 and circovirus 2 in primary porcine hepatocyte and kidney cell cultures. J Vet Med Sci 68, 179-182.
21. Ju, C., Fan, H., Tan, Y., Liu, Z., Xi, X., Cao, S., Wu, B. & Chen, H. (2005). Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2. Vet Microbiol 109, 179-190.
22. Kamstrup, S., Barfoed, A. M., Frimann, T. H., Ladekjaer-Mikkelsen, A. S. & Botner, A. (2004). Immunisation against PCV2 structural protein by DNA vaccination of mice. Vaccine 22, 1358-1361.
23. Kiupel, M., Stevenson, G. W., Choi, J., Latimer, K. S., Kanitz, C. L. & Mittal, S. K. (2001). Viral replication and lesions in BALB/c mice experimentally inoculated with porcine circovirus isolated from a pig with postweaning multisystemic wasting disease. Vet Pathol 38, 74-82.
24. Liu, J., Chen, I. & Kwang, J. (2005). Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. J Virol 79, 8262-8274.
25. Liu, J., Chen, I., Du, O., Chua, H. & Kwang, J. (2006). The ORF3 protein of porcine circovirus type 2 is involved in viral pathogenesis in vivo. J Virol 80, 5065-5073.
26. Mahe, D., Blanchard, P., Truong, C., Arnauld, C., Le Cann, P., Cariolet, R., Madec, F., Albina, E. & Jestin, A. (2000). Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes. J Gen Virol 81, 1815-1824.
27. Mankertz, A., Mankerkz, J., Wolf, K. & Buhk, H. J. (1998). Identification of a protein essential for replication of porcine circovirus. J Gen Virol 79, 381-384.
28. McIntosh, K. A., Harding, J. C., Ellis, J. A. & Appleyard, G. D. (2006). Detection of Porcine circovirus type 2 viremia and seroconversion in naturally infected pigs in a farrow-to-finish barn. Can J Vet Res 70, 58-61.
29. McKendall, R. R. & Woo, W. (1988). Murine IgG subclass responses to herpes simplex virus type 1 and polypeptides. J Gen Virol 69, 847-857.
30. McNeilly, F., McNair, I., Mackie, D. P., Meehan, B. M., Kennedy, S., Moffett, D., Ellis, J., Krakowka, S. & Allan, G. M. (2001). Production, characterisation and applications of monoclonal antibodies to porcine circovirus 2. Arch Virol 146, 909-922.
31. Meehan, B. M., McNeilly, F., Todd, D., Kennedy, S., Jewhurst V. A., Ellis, J. A., Hassard, L. E., Clark E. G., Haines, D. M. & Allan, G. M. (1998). Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J Gen Virol 79, 2171-2179.
32. Mosmann, T. R. & Coffman, R. L. (1989a). Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 46, 111-147.
33. Mosmann, T. R. & Coffman, R. L. (1989b). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7, 145-173.
34. Nawagitgul, P., Morozov, I., Bolin, S. R., Harms, P. A., Sorden, S. D. & Paul, P. S. (2000). Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. J Gen Virol 81, 2281-2287.
35. Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland-Jones, S. L. & other authors (1998). Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279, 2103-2106.
36. Quintana, J., Balasch, M., Segales, J., Calsamiglia, M, Rodriguez-Arrioja, G. M., Plana-Duran, J. & Domingo, M. (2002). Experimental inoculation of porcine circoviruses type 1 (PCV1) and type 2 (PCV2) in rabbits and mice. Vet Res 33, 229-237.
37. Ruitenberg, K. M., Walker, C., Love, D. N., Wellington, J. E. & Whalley, J. M. (2000). A prime-boost immunization strategy with DNA and recombinant baculovirus-expressed protein enhances protective immunogenicity of glycoprotein D of equine herpesvirus 1 in naive and infection-primed mice. Vaccine 18, 1367-1373.
38. Sarli, G., Mandrioli, L., Laurenti, M., Sidoli, L., Cerati, C., Rolla, G. & Marcato, P. S. (2001). Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 83, 53-67.
39. + lymphocytes. Science 283, 857-860.
40. Seder, R. A. & Hill, A. V. (2000). Vaccines against intracellular infections requiring cellular immunity. Nature 406, 793-798.
41. Segales, J., Domingo, M., Chianini, F, Majo, N., Dominguez, J., Darwich, L. & Mateu, E. (2004). Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet Microbiol 98, 151-158.
42. Shang, S. B., Li, Y. F., Guo, J. Q., Wang, Z. T., Chen, Q. X., Shen, H. G. & Zhou, J. Y. (2008). Development and validation of a recombinant capsid protein-based ELISA for detection of antibody to porcine circovirus type 2. Res Vet Sci 84, 150-157.
43. Simmons, M., Murphy, G. S., Kochel, T., Raviprakash, K. & Hayes C. G. (2001). Characterization of antibody responses to combinations of a dengue-2 DNA and dengue-2 recombinant subunit vaccine. Am J Trop Med Hyg 65, 420-426.
44. Sin, J. I., Bagarazzi, M., Pachuk, C. & Weiner, D. B. (1999). DNA priming-protein boosting enhances both antigen-specific antibody and Th1-type cellular immune responses in a murine herpes simplex virus-2 gD vaccine model. DNA Cell Biol 18, 771-779.
45. Song, Y., Jin, M., Zhang, S., Xu, X., Xiao, S., Cao, S. & Chen, H. (2007). Generation and immunogenicity of a recombinant pseudorabies virus expressing cap protein of porcine circovirus type 2. Vet Microbiol 119, 97-104.
46. Tanghe, A., D'Souza, S., Rosseels, V., Denis, O., Ottenhoff, T. H., Dalemans, W., Wheeler, C. & Huygen, K. (2001). Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting. Infect Immun 69, 3041-3047.
47. Tischer, I., Gelderblom, H., Vettermann, W. & Koch, M. A. (1982). A very small porcine virus with circular single-stranded DNA. Nature 295, 64-66.
48. Truong, C., Mahe, D., Blanchard, P., Le Dimna, M., Madec, F., Jestin, A. & Albina, E. (2001). Identification of an immunorelevant ORF2 epitope from porcine circovirus type 2 as a serological marker for experimental and natural infection. Arch Virol 146, 1197-1211.
49. Vincent I. E., Carrasco, C. P., Herrmann, B., Meehan, B. M., Allan, G. M., Summerfield, A. & McCullough, K. C. (2003). Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J Virol 77, 13288-13300.
50. Wang, X., Jiang, W., Jiang, P., Li, Y., Feng, Z. & Xu, J. (2006). Construction and immunogenicity of recombinant adenovirus expressing the capsid protein of porcine circovirus 2 (PCV2) in mice. Vaccine 24, 3374-3380.
51. Wang, X., Jiang, P., Li, Y., Jiang, W. & Dong, X. (2007). Protection of pigs against post-weaning multisystemic wasting syndrome by a recombinant adenovirus expressing the capsid protein of porcine circovirus type 2. Vet Microbiol 121, 215-224.
52. Wen, L., Guo, X. & Yang, H. (2005). Genotyping of porcine circovirus type 2 from a variety of clinical conditions in China. Vet Microbiol 110, 141-146.
53. Yu, S., Opriessnig, T., Kitikoon, P., Nilubol, D., Halbur, P. G. & Thacker, E. (2007). Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs. Vet Immunol Immunopathol 115, 261-272.
54. Zakhartchouk, A. N., Liu, Q., Petric, M. & Babiuk, L. A. (2005). Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines. Vaccine 23, 4385-4391.
55. Zhou, J. Y., Shang, S. B., Gong, H., Chen, Q. X., Wu, J. X., Shen, H. G., Chen, T. F. & Guo, J. Q. (2005a). In vitro expression, monoclonal antibody and bioactivity for capsid protein of porcine circovirus type II without nuclear localization signal. J Biotechnol 118, 201-211.
56. Zhou, J. Y., Wang, J. Y., Chen, J. G., Wu, J. X., Gong, H, Teng, Q. Y., Guo, J. Q. & Shen, H. G. (2005b). Cloning, in vitro expression and bioactivity of duck interleukin-2. Mol Immunol 42, 589-598.
57. Zhou, J. Y., Chen, Q. X., Ye, J. X., Shen, H. G., Chen, T. F. & Shang, S. B. (2006). Serological investigation and genomic characterization of PCV2 isolates from different geographic regions of Zhejiang province in China. Vet Res Commun 30, 205-220.