Pentraxins, humoral innate immunity and tissue injury

Current Opinion in Immunology

Volumn 20, Issue 5, 2008, Pages 538-544

  Manfredi, Angelo A ^a   Rovere Querini, Patrizia ^a   Bottazzi, Barbara ^b   Garlanda, Cecilia ^b   Mantovani, Alberto ^b,c  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; ADAPTOR PROTEIN; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C1Q; FIBROBLAST GROWTH FACTOR 2; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; PENTRAXIN; PENTRAXIN 3; TOLL LIKE RECEPTOR 4;

ANTIGEN PRESENTING CELL; AUTOIMMUNITY; CELL DEATH; CELL FUNCTION; COMPLEMENT ACTIVATION; DENDRITIC CELL; EXTRACELLULAR MATRIX; HUMAN; HUMORAL IMMUNITY; HYPERPLASIA; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; REGULATORY MECHANISM; REVIEW; RISK ASSESSMENT; SCAR FORMATION; TISSUE INJURY;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIBODY FORMATION; APOPTOSIS; C-REACTIVE PROTEIN; HUMANS; INFLAMMATION; MICE; SERUM AMYLOID P-COMPONENT; WOUNDS AND INJURIES;

EID: 50549089457     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.05.004     Document Type: Review

References (54)

1. Pepys M.B., and Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 111 (2003) 1805-1812
2. Garlanda C., Bottazzi B., Bastone A., and Mantovani A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol 23 (2005) 337-366
3. Garlanda C., Hirsch E., Bozza S., Salustri A., De Acetis M., Nota R., Maccagno A., Riva F., Bottazzi B., Peri G., et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 420 (2002) 182-186
4. Reading P.C., Bozza S., Gilbertson B., Tate M., Moretti S., Job E.R., Crouch E.C., Brooks A.G., Brown L.E., Bottazzi B., et al. Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses. J Immunol 180 (2008) 3391-3398
5. Inforzato A., Rivieccio V., Morreale A.P., Bastone A., Salustri A., Scarchilli L., Verdoliva A., Vincenti S., Gallo G., Chiapparino C., et al. Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization. J Biol Chem 283 (2008) 10147-10161
6. Camozzi M., Rusnati M., Bugatti A., Bottazzi B., Mantovani A., Bastone A., Inforzato A., Vincenti S., Bracci L., Mastroianni D., et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem 281 (2006) 22605-22613
7. Camozzi M., Zacchigna S., Rusnati M., Coltrini D., Ramirez-Correa G., Bottazzi B., Mantovani A., Giacca M., and Presta M. Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo. Arterioscler Thromb Vasc Biol 25 (2005) 1837-1842
8. Mantovani A., Garlanda C., Doni A., and Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 28 (2008) 1-13
9. Nauta A.J., Bottazzi B., Mantovani A., Salvatori G., Kishore U., Schwaeble W.J., Gingras A.R., Tzima S., Vivanco F., Egido J., et al. Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol 33 (2003) 465-473
10. Roumenina L.T., Ruseva M.M., Zlatarova A., Ghai R., Kolev M., Olova N., Gadjeva M., Agrawal A., Bottazzi B., Mantovani A., et al. Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains. Biochemistry 45 (2006) 4093-4104
11. Sjoberg A.P., Trouw L.A., McGrath F.D., Hack C.E., and Blom A.M. Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. J Immunol 176 (2006) 7612-7620
12. Baruah P., Dumitriu I.E., Peri G., Russo V., Mantovani A., Manfredi A.A., and Rovere-Querini P. The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells. J Leukoc Biol 80 (2006) 87-95
13. Janssen W.J., McPhillips K.A., Dickinson M.G., Linderman D.J., Morimoto K., Xiao Y.Q., Oldham K.M., Vandivier R.W., Henson P.M., and Gardai S.J. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP{alpha}. Am J Respir Crit Care Med 178 (2008) 158-167
14. Mori R., Shaw T.J., and Martin P. Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J Exp Med 205 (2008) 43-51. An elegant investigation addressing the molecular constrains on to the outcomes of tissue injury.
15. Bianchi M.E., and Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 220 (2007) 35-46
16. Rock K.L., and Kono H. The inflammatory response to cell death. Annu Rev Pathol 3 (2008) 99-126
17. •], provide compelling evidences for the involvement of innate receptors and downstream signalling pathways in shaping the inflammatory response to tissue injury.
18. Tesniere A., Panaretakis T., Kepp O., Apetoh L., Ghiringhelli F., Zitvogel L., and Kroemer G. Molecular characteristics of immunogenic cancer cell death. Cell Death Differ 15 (2008) 3-12
19. •].
20. •].
21. Cook H.T., and Botto M. Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus. Nat Clin Pract Rheumatol 2 (2006) 330-337
22. Meri S. Loss of self-control in the complement system and innate autoreactivity. Ann N Y Acad Sci 1109 (2007) 93-105
23. Padilla N.D., van Vliet A.K., Schoots I.G., Seron M.V., Maas M.A., Peltenburg E.E., de Vries A., Niessen H.W., Hack C.E., and van Gulik T.M. C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. Surgery 142 (2007) 722-733
24. Szeplaki G., Hirschberg K., Gombos T., Varga L., Prohaszka Z., Dosa E., Acsady G., Karadi I., Garred P., Entz L., et al. Early complement activation follows eversion carotid endarterectomy and correlates with the time of clamping of the carotid artery. Mol Immunol 45 (2008) 3289-3294
25. Zhang M., Alicot E.M., Chiu I., Li J., Verna N., Vorup-Jensen T., Kessler B., Shimaoka M., Chan R., Friend D., et al. Identification of the target self-antigens in reperfusion injury. J Exp Med 203 (2006) 141-152
26. Suber F., Carroll M.C., and Moore Jr. F.D. Innate response to self-antigen significantly exacerbates burn wound depth. Proc Natl Acad Sci U S A 104 (2007) 3973-3977
27. Doni A., Michela M., Bottazzi B., Peri G., Valentino S., Polentarutti N., Garlanda C., and Mantovani A. Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma. J Leukoc Biol 79 (2006) 797-802
28. Luchetti M.M., Piccinini G., Mantovani A., Peri G., Matteucci C., Pomponio G., Fratini M., Fraticelli P., Sambo P., Di Loreto C., et al. Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA). Clin Exp Immunol 119 (2000) 196-202
29. Savchenko A., Imamura M., Ohashi R., Jiang S., Kawasaki T., Hasegawa G., Emura I., Iwanari H., Sagara M., Tanaka T., et al. Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. J Pathol 215 (2008) 48-55
30. Norata G.D., Marchesi P., Pirillo A., Uboldi P., Chiesa G., Maina V., Garlanda C., Mantovani A., and Catapano A.L. Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells. Arterioscler Thromb Vasc Biol 28 (2008) 925-931
31. Gustin C., Delaive E., Dieu M., Calay D., and Raes M. Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure. Arterioscler Thromb Vasc Biol 28 (2008) 491-497
32. Mallat Z., and Tedgui A. HDL, PTX3, and vascular protection. Arterioscler Thromb Vasc Biol 28 (2008) 809-811
33. Jaillon S., Peri G., Delneste Y., Fremaux I., Doni A., Moalli F., Garlanda C., Romani L., Gascan H., Bellocchio S., et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 204 (2007) 793-804. This study demonstrates that neutrophils, early comers at sites of injury, store in specific granules pre-formed PTX3, ready for immediate release.
34. •], demonstrate the involvement of PTX3 in normal pregnancy and in its common complication, preeclampsia.
35. •].
36. Nolan S.L., Kalia N., Nash G.B., Kamel D., Heeringa P., and Savage C.O. Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo. J Am Soc Nephrol 19 (2008) 973-984
37. Fazzini F., Peri G., Doni A., Dell'Antonio G., Dal Cin E., Bozzolo E., D'Auria F., Praderio L., Ciboddo G., Sabbadini M.G., et al. PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation. Arthritis Rheum 44 (2001) 2841-2850
38. Rovere P., Peri G., Fazzini F., Bottazzi B., Doni A., Bondanza A., Zimmermann V.S., Garlanda C., Fascio U., Sabbadini M.G., et al. The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood 96 (2000) 4300-4306
39. van Rossum A.P., Fazzini F., Limburg P.C., Manfredi A.A., Rovere-Querini P., Mantovani A., and Kallenberg C.G. The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages. Arthritis Rheum 50 (2004) 2667-2674
40. van Rossum A.P., Pas H.H., Fazzini F., Huitema M.G., Limburg P.C., Jonkman M.F., and Kallenberg C.G. Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis. Arthritis Rheum 54 (2006) 986-991
41. Kotooka N., Inoue T., Fujimatsu D., Morooka T., Hashimoto S., Hikichi Y., Uchida T., Sugiyama A., and Node K. Pentraxin3 is a novel marker for stent-induced inflammation and neointimal thickening. Atherosclerosis 197 (2008) 368-374
42. Okutani D., Han B., Mura M., Waddell T.K., Keshavjee S., and Liu M. High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. Am J Physiol Lung Cell Mol Physiol 292 (2007) L144-153
43. Salio M., Chimenti S., De Angelis N., Molla F., Maina V., Nebuloni M., Pasqualini F., Latini R., Garlanda C., and Mantovani A. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation 117 (2008) 1055-1064. This study provides a stringent genetic demonstration of the non-redundant role of pentraxins in shaping the tissue response to ischemia/reperfusion injury.
44. Latini R., Maggioni A.P., Peri G., Gonzini L., Lucci D., Mocarelli P., Vago L., Pasqualini F., Signorini S., Soldateschi D., et al. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation 110 (2004) 2349-2354
45. Peng Y., Kowalewski R., Kim S., and Elkon K.B. The role of IgM antibodies in the recognition and clearance of apoptotic cells. Mol Immunol 42 (2005) 781-787
46. Gillmore J.D., Hutchinson W.L., Herbert J., Bybee A., Mitchell D.A., Hasserjian R.P., Yamamura K., Suzuki M., Sabin C.A., and Pepys M.B. Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?. Immunology 112 (2004) 255-264
47. Baruah P., Propato A., Dumitriu I.E., Rovere-Querini P., Russo V., Fontana R., Accapezzato D., Peri G., Mantovani A., Barnaba V., et al. The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens. Blood 107 (2006) 151-158
48. Bondanza A., Zimmermann V.S., Dell'Antonio G., Cin E.D., Balestrieri G., Tincani A., Amoura Z., Piette J.C., Sabbadini M.G., Rovere-Querini P., et al. Requirement of dying cells and environmental adjuvants for the induction of autoimmunity. Arthritis Rheum 50 (2004) 1549-1560
49. Rodriguez W., Mold C., Kataranovski M., Hutt J.A., Marnell L.L., Verbeek J.S., and Du Clos T.W. C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. J Immunol 178 (2007) 530-538
50. Bickerstaff M.C., Botto M., Hutchinson W.L., Herbert J., Tennent G.A., Bybee A., Mitchell D.A., Cook H.T., Butler P.J., Walport M.J., et al. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med 5 (1999) 694-697
51. Pepys M.B., Hirschfield G.M., Tennent G.A., Gallimore J.R., Kahan M.C., Bellotti V., Hawkins P.N., Myers R.M., Smith M.D., Polara A., et al. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440 (2006) 1217-1221
52. Presta M., Camozzi M., Salvatori G., and Rusnati M. Role of the soluble pattern recognition receptor PTX3 in vascular biology. J Cell Mol Med 11 (2007) 723-738
53. Naik-Mathuria B., Pilling D., Crawford J.R., Gay A.N., Smith C.W., Gomer R.H., and Olutoye O.O. Serum amyloid P inhibits dermal wound healing. Wound Repair Regen 16 (2008) 266-273. Authors report that SAP regulates the reparative response to peritoneal and skin lesions.
54. Rovere-Querini P., Capobianco A., Scaffidi P., Valentinis B., Catalanotti F., Giazzon M., Dumitriu I.E., Müller S., Iannacone M., Traversari C., et al. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 5 (2004) 825-830