Brain fatty acid profiles and spatial learning in malnourished rats: Effects of nutritional intervention

Nutritional Neuroscience

Volumn 11, Issue 3, 2008, Pages 119-127

  Santos de Souza, Amanda ^a   da Camara Pacheco, Luciana ^a   da Silva Castro, Priscila ^a   Hokoç, Jan Nora ^a   Santos Rocha, Mônica ^a   Tavares do Carmo, Maria das Graças ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Brain fatty acids; Malnutrition; Morris water maze; Nutritional rehabilitation; Passive avoidance; Regional basic diet

Indexed keywords

ARACHIDONIC ACID; DOCOSAPENTAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; WATER;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BEAN; BRAZIL; CEREBELLUM; CONTROLLED STUDY; DIET THERAPY; FEMALE; FLOUR; FOOD COMPOSITION; FOOD INTAKE; GAS LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; LACTATION; LEARNING; LIPID COMPOSITION; MALE; MALNUTRITION; MAZE TEST; MEAT; MEMORY CONSOLIDATION; NONHUMAN; PASSIVE AVOIDANCE; PREGNANCY; PRIORITY JOURNAL; PROGENY; RAT; SWEET POTATO; TASK PERFORMANCE; WEANING;

ANIMALS; AVOIDANCE LEARNING; BRAIN CHEMISTRY; CEREBELLUM; DIET; FATTY ACIDS; FEMALE; HIPPOCAMPUS; LACTATION; LEARNING; MALNUTRITION; MAZE LEARNING; PREGNANCY; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 50449107805     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/147683008X301504     Document Type: Article

References (47)

1. Yamamoto N, Hashimoto A, Takemoto Y et al. Effect of the dietary α-linolenate/linoleate balance on lipid compositions and learning ability of rats. II-Discrimination process, extinction process, and glycolipid compositions. J Lipid Res 1988; 29: 1013-1021.
2. Frances H, Coudreau JP, Sandouk P et al. Influence of dietary α-linolenic acid deficiency on learning in the Morris water maze and on the effects of morphine. Eur J Pharmacol 1996; 298: 217-225.
3. Favrelière S, Barrier L, Durand G et al. Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidyl-ethanolamine differently in rat frontal cortex, striatum, and cerebellum. Lipids 1998; 33: 401-407.
4. Angulo-Guerrero O, Oliart RR. Effects of dietary polyunsaturated fatty acids on rat brain plasma membrane fatty acid composition. Arch Latinoam Nutr 1998; 48: 287-292.
5. Wilde MC, Farkas E, Gerrits M et al. The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion. Brain Res 2002; 947: 166-173.
6. Barceló-Coblijn G, Kitajka K, Puskás LG et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. Biochim Biophys Acta 2003; 1632: 72-79.
7. Kalmijn S, Launer LJ, Ott A et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997 42: 776-782.
8. Terano T, Fujishiro S, Ban T et al. Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids 1999; 34: 345s-346s.
9. Jensen MM, Skarsfeldt T, Hoy C. Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study. Biochim Biophys Acta 1996; 1300: 203-209.
10. Chafetz MD. Nutrition and neurotransmitters. The nutrient bases of behavior. Englewood Cliffs, NJ: Prentice Hall, 1990.
11. Tam O, Innis SM. Dietary polyunsaturated fatty acids in gestation alter fetal cortical phospholipids, fatty acids, and phosphatidylserine synthesis. Dev Neurosci 2006; 28: 222-229.
12. Teodósio NR, Lago ES, Romani SAM et al. A regional basic diet from northeast Brazil as a dietary model of experimental malnutrition. Arch Latinoam Nutr 1990; 40: 533-547.
13. Netto CA, Izquierdo I. On how passive is inhibitory avoidance? Behav Neural Biol 1985; 43: 327-330.
14. Morris RG. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984; 11: 47-60.
15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
16. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986; 27: 114-120.
17. Lukoyanov NV, Andrade JP. Behavioral effects of protein deprivation and rehabilitation in adult rats: Relevance to morphological alterations in the hippocampal formation. Behav Brain Res 2000; 112: 85-97.
18. Colombel C, Lalonde R, Caston J. The effects of unilateral removal of the cerebellar hemispheres on spatial learning and memory in rats. Brain Res 2004; 1004: 108-115.
19. Winick M. Effects of malnutrition on the maturing central nervous system. Adv Neurol 1975; 13: 193-246.
20. Levitsky DA, Barnes RH. Effects of early malnutrition on the reaction in adult rats to aversive stimuli. Nature 1970; 225: 468-469.
21. Strupp BJ, Levitsky, DA. Enduring cognitive effects of early malnutrition: A theoretical reappraisal. J Nutr 1995; 125: 2221s-2232s.
22. Almeida SS, Tonkiss J, Galler JR. Prenatal protein malnutrition affects the social interaction of juvenile rats. Physiol Behav 1996; 60: 197-201.
23. Almeida SS, Tonkiss J, Galler JR. Prenatal protein malnutrition affects exploratory behavior of female rats in the elevated plus-maze test. Physiol Behav 1996; 60: 675-680.
24. Smith LK, Metz GA. Dietary restriction alters fine motor function in rats. Physiol Behav 2005; 85: 581-592.
25. Paixão ADO, Alessio ML, Martins JP et al. Regional Brazilian diet-induced pre-natal malnutrition in rats is correlated with the proliferation of cultured vascular smooth muscle cells. Nutr Metab Cardiovasc Dis 2005; 15: 302-309.
26. Oteiza PI, Hurley LS, Lönnerdal B et al. Effects of marginal zinc deficiency on microtubule polymerization in the developing rat brain. Biol Trace Element Res 1990; 24: 13-23.
27. Bennis-Taleb N, Remacle C, Hoet JJ et al. A low-protein isocaloric diet during gestation affects brain development and alters permanently cerebral cortex blood vessels in rat offspring. J Nutr 1999; 129: 1613-1619.
28. Fukuda MTH, Françolin-Silva AL, Almeida SS. Early postnatal protein malnutrition affects learning and memory in the distal but not in the proximal cue version of the Morris water maze. Behav Brain Res 2002; 133: 271-277.
29. Lukoyanov NV, Madeira MD, Paula-Barbosa MM. Behavioral and neuroanatomical consequences of chronic ethanol intake and withdrawal. Physiol Behav 1999; 66: 337-346.
30. Phelps EA, LeDoux JE. Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron 2005; 48: 175-187.
31. Marteinsdottir I, Horrobin DF, Stenfors C et al. Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain. Prog Neuropsychopharmacol Biol Psychiatry 1998; 22: 1007-1021.
32. Funahashi S, Bruce CJ, Goldman-Rakic PS. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: Evidence for mnemonic 'scotomas'. J Neurosci 1993; 13: 1479-1497.
33. Francolin-Silva AL, Almeida SS. The interaction of housing condition and acute immobilization stress on the elevated plus-maze behaviors of protein-malnourished rats. Braz J Med Biol Res 2004; 37: 1035-1042.
34. Smit EN, Muskiet FAJ, Boersma ER. The possible role of essential fatty acids in the pathophysiology of malnutrition: A review Prostaglandins Leukot Essent Fatty Acids 2004; 71: 241-250.
35. Singh RB, Pella D, Mechirova V et al. Can brain dysfunction be a predisposing factor for metabolic syndrome? Biomed Pharmacol 2004; 58: 56s-68s.
36. Yu N, Martin JL, Stella N et al. Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes. Proc Natl Acad Sci USA 1993; 90: 4042-4046.
37. Ragozzino ME, Unick KE, Gold PE. Hippocampal acetylcholine release during memory testing in rats: Augmentation by glucose. Proc Natl Acad Sci USA 1996; 93: 4693-4698.
38. Minami M, Kimura S, Endo T et al. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance-performance in stroke-prone spontaneously hypertensive rats. Pharmacol Biochem Behav 1997; 58: 1123-1129.
39. Hersi AI, Kitaichi K, Srivastav LK et al. Dopamine D-5 receptor modulates hippocampal acetylcholine release. Brain Res Mol Brain Res 2000; 76: 336-340.
40. Alamy M, Errami M, Taghzouti K et al. Effects of postweaning undernutrition on exploratory behavior, memory and sensory reactivity in rats: Implication of the dopaminergic system. Physiol Behav 2005; 86: 195-202.
41. Fibiger H. Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence. Trends Neurosci 1991; 14: 220-223.
42. Wainwright PE. Dietary essential fatty acids and brain function: A developmental perspective on mechanisms. Proc Nutr Soc 2002 61: 61-69.
43. Carrie I, Guesnet P, Bourre JM et al. Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice. Br J Nutr 2000; 83: 439-447.
44. Wainwright PE, Javali E, Mutsaers LM et al. An imbalance of dietary essential fatty acids retards behavioral development in mice. Physiol Behav 1999; 66: 833-839.
45. Wainwright PE. Do essential fatty acids play a role in brain and behavioral development? Neurosci Biobehav Rev 1992; 16: 193-205.
46. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and the brain: From infancy to aging. Neurobiol Aging 2005; 26: 98s-102s.
47. Das UN. Essential fatty acids: Biochemistry, physiology and pathology. Biotechnol J 2006; 1: 420-439.