Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy

Veterinary Journal

Volumn 178, Issue 1, 2008, Pages 126-129

  Tortosa, Raül ^a   Vidal, Enric ^b   Costa, Carme ^a   Alamillo, Elia ^c   Torres, Juan Maria ^c   Ferrer, Isidre ^d   Pumarola, Martí ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^c Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Bovine spongiform encephalopathy; Glia; Mouse model; Pathogenesis; Prion; Stress

Indexed keywords

HEAT SHOCK PROTEIN 25; METALLOTHIONEIN I; METALLOTHIONEIN II; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN HOMOGENATE; CATTLE; CELL PROLIFERATION; CONTROLLED STUDY; GLIA CELL; IMMUNOHISTOCHEMISTRY; INOCULATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; CATTLE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; ENCEPHALOPATHY, BOVINE SPONGIFORM; HEAT-SHOCK PROTEINS; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; NEUROGLIA; OXIDATIVE STRESS; PRIONS;

BOS; BOVINAE; MURINAE; MUS; MUS MUSCULUS;

EID: 50449098986     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.06.002     Document Type: Article

References (11)

1. Brown D.R., Wong B.S., Hafiz F., Clive C., Haswell S.J., and Jones I.M. Normal prion protein has an activity like that of superoxide dismutase. Biochemical Journal 344 (1999) 1-5
2. res in BSE-infected bovine PrP transgenic mice. Archives of Virology 148 (2003) 677-691
3. Foster J.D., Parnham D., Chong A., Goldmann W., and Hunter N. Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats. Veterinary Record 148 (2001) 165-171
4. Hanlon J., Monks E., Hughes C., Weavers E., and Rogers M. Metallothionein in bovine spongiform encephalopathy. Journal of Comparative Pathology 127 (2002) 280-289
5. Hidalgo J., Aschner M., Zatta P., and Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Research Bulletin 55 (2001) 133-145
6. Kramer M.L., Kratzin H.D., Schmidt B., Romer A., Windl O., Liemann S., Hornemann S., and Kretzschmar H. Prion protein binds copper within the physiological concentration range. Journal of Biological Chemistry 276 (2001) 16711-16719
7. Sales, N., Adjou, K., Kadiysky, D., Aubry, F., Créminon, C., Maignien, T., Lasmézas, C.I., Deslys, J.P., 2004. Vimentin and HSP25 expression in astrocytes during rodent experimental scrapie. In: Prion 2004: First International Conference of the European Network of Excellence NeuroPrion, p. 177.
8. res in the brains of BSE-affected cows detected by active surveillance in Catalonia, Spain. Veterinary Record 155 (2004) 524-525
9. Unterberger U., Voigtlander T., and Budka H. Pathogenesis of prion diseases. Acta Neuropathologica (Berl) 109 (2005) 32-48
10. Vidal E., Marquez M., Tortosa R., Costa C., Serafin A., and Pumarola M. Immunohistochemical approach to the pathogenesis of bovine spongiform encephalopathy in its early stages. Journal of Virological Methods 134 (2006) 15-29
11. Wells G.A., Hawkins S.A., Green R.B., Austin A.R., Dexter I., Spencer Y.I., Chaplin M.J., Stack M.J., and Dawson M. Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update. Veterinary Record 142 (1998) 103-106