Present and future of clinical cardiovascular PET imaging in Europe - A position statement by the European Council of Nuclear Cardiology (ECNC)

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 35, Issue 9, 2008, Pages 1709-1724

  Le Guludec, D ^a,e   Lautamaki R ^b   Knuuti, J ^c   Bax, J J ^d   Bengel, F M ^b  

^a BICHAT HOSPITAL   (France)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TURKU   (Finland)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e European Council of Nuclear Cardiology   (Austria)

Author keywords

Cardiology PET; FDG; Molecular imaging; Myorcardial blood flow; PET; PET CT

Indexed keywords

FLUORODEOXYGLUCOSE F 18; TRACER;

ATHEROSCLEROTIC PLAQUE; CLINICAL DECISION MAKING; CLINICAL RESEARCH; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; EUROPE; HEALTH CARE QUALITY; HEART MUSCLE PERFUSION; HUMAN; MOLECULAR IMAGING; NON INVASIVE MEASUREMENT; POSITRON EMISSION TOMOGRAPHY; PREDICTION; RADIATION EXPOSURE; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

CARDIOLOGY; CARDIOVASCULAR DISEASES; EUROPE; HUMANS; NUCLEAR MEDICINE; POSITRON-EMISSION TOMOGRAPHY; SOCIETIES, MEDICAL;

EID: 50449088807     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0859-1     Document Type: Review

References (124)

1. B Hesse TB Lindhardt W Acampa C Anagnostopoulos J Ballinger JJ Bax 2008 EANM/ESC guidelines for radionuclide imaging of cardiac function Eur J Nucl Med Mol Imaging 35 851 885
2. B Hesse K Tagil A Cuocolo C Anagnostopoulos M Bardies J Bax 2005 EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology Eur J Nucl Med Mol Imaging 32 855 897
3. C Marcassa JJ Bax F Bengel B Hesse CL Petersen E Reyes 2008 Clinical value, cost-effectiveness, and safety of myocardial perfusion scintigraphy: a position statement Eur Heart J 29 557 563
4. C Marcassa DA Bischof A Cuocolo B Hesse P Kaufmann J Knuuti 2006 The regulatory background of nuclear cardiology in Europe: a survey by the European Council of Nuclear Cardiology Eur J Nucl Med Mol Imaging 33 1508 1512
5. R Hachamovitch SW Hayes JD Friedman I Cohen DS Berman 2004 Stress myocardial perfusion single-photon emission computed tomography is clinically effective and cost effective in risk stratification of patients with a high likelihood of coronary artery disease (CAD) but no known CAD J Am Coll Cardiol 43 200 208
6. FJ Klocke MG Baird BH Lorell TM Bateman JV Messer DS Berman 2003 ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging) Circulation 108 1404 1418
7. LJ Shaw R Hendel S Borges-Neto MS Lauer N Alazraki J Burnette 2003 Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients J Nucl Med 44 134 139
8. P Rigo BP Van J Foulon M Safi J Engdahl J Links 1998 Quantitative evaluation of a comprehensive motion, resolution, and attenuation correction program: initial experience J Nucl Cardiol 5 458 468
9. N Tamaki Y Yonekura M Senda K Yamashita H Koide H Saji 1988 Value and limitation of stress thallium-201 single photon emission computed tomography: comparison with nitrogen-13 ammonia positron tomography J Nucl Med 29 1181 1188
10. W Martin AC Tweddel I Hutton 1992 Balanced triple-vessel disease: enhanced detection by estimated myocardial thallium uptake Nucl Med Commun 13 149 153
11. TM Bateman J Maddahi RJ Gray FL Murphy EV Garcia CM Conklin 1984 Diffuse slow washout of myocardial thallium-201: a new scintigraphic indicator of extensive coronary artery disease J Am Coll Cardiol 4 55 64
12. WH Aarnoudse KJ Botman NH Pijls 2003 False-negative myocardial scintigraphy in balanced three-vessel disease, revealed by coronary pressure measurement Int J Cardiovasc Intervent 5 67 71
13. 2O PET Eur J Nucl Med Mol Imaging 30 281 287
14. HR Schelbert WL Ashburn DM Chauncey SE Halpern 1974 Comparative myocardial uptake of intravenously administered radionuclides J Nucl Med 15 1092 1100
15. A Rahmim H Zaidi 2008 PET versus SPECT: strengths, limitations and challenges Nucl Med Commun 29 193 207
16. R Lautamaki TL Brown J Merrill FM Bengel 2008 CT-based attenuation correction in (82)Rb-myocardial perfusion PET-CT: incidence of misalignment and effect on regional tracer distribution Eur J Nucl Med Mol Imaging 35 305 310
17. KL Gould T Pan C Loghin NP Johnson A Guha S Sdringola 2007 Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: a definitive analysis of causes, consequences, and corrections J Nucl Med 48 1112 1121
18. A Martinez-Moller M Souvatzoglou N Navab M Schwaiger SG Nekolla 2007 Artifacts from misaligned CT in cardiac perfusion PET/CT studies: frequency, effects, and potential solutions J Nucl Med 48 188 193
19. AM Alessio S Kohlmyer K Branch G Chen J Caldwell P Kinahan 2007 Cine CT for attenuation correction in cardiac PET/CT J Nucl Med 48 794 801
20. RE Patterson KB Churchwell RL Eisner 1996 Diagnosis of coronary artery disease in women: roles of three dimensional imaging with magnetic resonance or positron emission tomography Am J Card Imaging 10 78 88
21. K Knesaurek J Machac BR Krynyckyi OD Almeida 2003 Comparison of 2-dimensional and 3-dimensional 82Rb myocardial perfusion PET imaging J Nucl Med 44 1350 1356
22. S Dorbala D Vangala U Sampson A Limaye R Kwong MF Di Carli 2007 Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: a 82Rb PET/CT study J Nucl Med 48 349 358
23. TL Brown J Merrill L Volokh FM Bengel 2008 Determinants of the response of left ventricular ejection fraction to vasodilator stress in electrocardiographically gated (82)rubidium myocardial perfusion PET Eur J Nucl Med Mol Imaging 35 336 342
24. A Martinez-Moller D Zikic RM Botnar RA Bundschuh W Howe SI Ziegler 2007 Dual cardiac-respiratory gated PET: implementation and results from a feasibility study Eur J Nucl Med Mol Imaging 34 1447 1454
25. KP Schafers L Stegger 2008 Combined imaging of molecular function and morphology with PET/CT and SPECT/CT: image fusion and motion correction Basic Res Cardiol 103 191 199
26. J Machac 2005 Cardiac positron emission tomography imaging Semin Nucl Med 35 17 36
27. SR Bergmann KA Fox AL Rand KD McElvany MJ Welch J Markham 1984 Quantification of regional myocardial blood flow in vivo with H215O Circulation 70 724 733
28. AP Selwyn RM Allan A L'Abbate P Horlock P Camici J Clark 1982 Relation between regional myocardial uptake of rubidium-82 and perfusion: absolute reduction of cation uptake in ischemia Am J Cardiol 50 112 121
29. RA Goldstein NA Mullani SK Marani DJ Fisher KL Gould HA O'Brien Jr 1983 Myocardial perfusion with rubidium-82. II. Effects of metabolic and pharmacologic interventions J Nucl Med 24 907 915
30. AM Groves ME Speechly-Dick JC Dickson I Kayani R Endozo P Blanchard 2007 Cardiac 82Rubidium PET/CT: initial European experience Eur J Nucl Med Mol Imaging 34 1965 1972
31. J Knuuti HR Schelbert JJ Bax 2002 The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction Eur J Nucl Med Mol Imaging 29 1257 1266
32. MJ Knuuti P Nuutila U Ruotsalainen M Saraste R Harkonen A Ahonen 1992 Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography J Nucl Med 33 1255 1262
33. SL Bacharach JJ Bax J Case D Delbeke KA Kurdziel WH Martin 2003 PET myocardial glucose metabolism and perfusion imaging: part 1-guidelines for data acquisition and patient preparation J Nucl Cardiol 10 543 556
34. MJ Knuuti H Yki-Jarvinen LM Voipio-Pulkki M Maki U Ruotsalainen R Harkonen 1994 Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative J Nucl Med 35 989 998
35. JJ Bax MA Veening FC Visser LA van RJ Heine JH Cornel 1997 Optimal metabolic conditions during fluorine-18 fluorodeoxyglucose imaging; a comparative study using different protocols Eur J Nucl Med 24 35 41
36. AJ Einstein KW Moser RC Thompson MD Cerqueira MJ Henzlova 2007 Radiation dose to patients from cardiac diagnostic imaging Circulation 116 1290 1305
37. RC Thompson SJ Cullom 2006 Issues regarding radiation dosage of cardiac nuclear and radiography procedures J Nucl Cardiol 13 19 23
38. AR Schleipman FP Castronovo Jr. MF Di Carli S Dorbala 2006 Occupational radiation dose associated with Rb-82 myocardial perfusion positron emission tomography imaging J Nucl Cardiol 13 378 384
39. MF Di Carli R Hachamovitch 2007 New technology for noninvasive evaluation of coronary artery disease Circulation 115 1464 1480
40. TM Bateman GV Heller AI McGhie JD Friedman JA Case JR Bryngelson 2006 Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT J Nucl Cardiol 13 24 33
41. UK Sampson S Dorbala A Limaye R Kwong MF Di Carli 2007 Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease J Am Coll Cardiol 49 1052 1058
42. TH Marwick K Shan S Patel RT Go MS Lauer 1997 Incremental value of rubidium-82 positron emission tomography for prognostic assessment of known or suspected coronary artery disease Am J Cardiol 80 865 870
43. K Yoshinaga BJ Chow K Williams L Chen RA Dekemp L Garrard 2006 What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 48 1029 1039
44. MP Schenker S Dorbala EC Hong FJ Rybicki R Hachamovitch RY Kwong 2008 Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study Circulation 117 1693 1700
45. RE Patterson RL Eisner SF Horowitz 1995 Comparison of cost-effectiveness and utility of exercise ECG, single photon emission computed tomography, positron emission tomography, and coronary angiography for diagnosis of coronary artery disease Circulation 91 54 65
46. KL Gould RA Goldstein NA Mullani 1989 Economic analysis of clinical positron emission tomography of the heart with rubidium-82 J Nucl Med 30 707 717
47. ME Merhige WJ Breen V Shelton T Houston BJ D'Arcy AF Perna 2007 Impact of myocardial perfusion imaging with PET and (82)Rb on downstream invasive procedure utilization, costs, and outcomes in coronary disease management J Nucl Med 48 1069 1076
48. J Tillisch R Brunken R Marshall M Schwaiger M Mandelkern M Phelps 1986 Reversibility of cardiac wall-motion abnormalities predicted by positron tomography N Engl J Med 314 884 888
49. N Tamaki Y Yonekura K Yamashita H Ohtani K Hirata T Ban 1991 Prediction of reversible ischemia after coronary artery bypass grafting by positron emission tomography J Cardiol 21 193 201
50. EG DePuey M Ghesani M Schwartz M Friedman K Nichols H Salensky 1999 Comparative performance of gated perfusion SPECT wall thickening, delayed thallium uptake, and F-18 fluorodeoxyglucose SPECT in detecting myocardial viability J Nucl Cardiol 6 418 428
51. RO Bonow V Dilsizian A Cuocolo SL Bacharach 1991 Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction. Comparison of thallium scintigraphy with reinjection and PET imaging with 18F-fluorodeoxyglucose Circulation 83 26 37
52. RT Go WJ MacIntyre GB Saha SA Cook DR Neumann EQ Chen 1995 Hibernating myocardium versus scar: severity of irreversible decreased myocardial perfusion in prediction of tissue viability Radiology 194 151 155
53. C Altehoefer DJ vom M Biedermann R Uebis I Beilin F Sheehan 1994 Significance of defect severity in technetium-99m-MIBI SPECT at rest to assess myocardial viability: comparison with fluorine-18-FDG PET J Nucl Med 35 569 574
54. H Schoder R Campisi T Ohtake CK Hoh DH Moon J Czernin 1999 Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction J Am Coll Cardiol 33 1328 1337
55. HM Siebelink PK Blanksma HJ Crijns JJ Bax AJ van Boven T Kingma 2001 No difference in cardiac event-free survival between positron emission tomography-guided and single-photon emission computed tomography-guided patient management: a prospective, randomized comparison of patients with suspicion of jeopardized myocardium J Am Coll Cardiol 37 81 88
56. JJ Bax FC Visser PK Blanksma MA Veening ES Tan TM Willemsen 1996 Comparison of myocardial uptake of fluorine-18-fluorodeoxyglucose imaged with PET and SPECT in dyssynergic myocardium J Nucl Med 37 1631 1636
57. TH Marwick C Zuchowski MS Lauer MA Secknus J Williams BW Lytle 1999 Functional status and quality of life in patients with heart failure undergoing coronary bypass surgery after assessment of myocardial viability J Am Coll Cardiol 33 750 758
58. S Sawada G Elsner DS Segar M O'Shaughnessy S Khouri J Foltz 1997 Evaluation of patterns of perfusion and metabolism in dobutamine-responsive myocardium J Am Coll Cardiol 29 55 61
59. MA Mariani C Palagi F Donatelli G Mengozzi O Biadi G Vanoli 1995 Identification of hibernating myocardium: a comparison between dobutamine echocardiography and study of perfusion and metabolism in patients with severe left ventricular dysfunction Am J Card Imaging 9 1 8
60. D Pagano RS Bonser JN Townend F Ordoubadi R Lorenzoni PG Camici 1998 Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure Heart 79 281 288
61. RJ Kim E Wu A Rafael EL Chen MA Parker O Simonetti 2000 The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction N Engl J Med 343 1445 1453
62. C Klein SG Nekolla FM Bengel M Momose A Sammer F Haas 2002 Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography Circulation 105 162 167
63. TA Kaandorp HJ Lamb EE van der Wall RA de JJ Bax 2005 Cardiovascular MR to access myocardial viability in chronic ischaemic LV dysfunction Heart 91 1359 1365
64. AF Schinkel JJ Bax D Poldermans A Elhendy R Ferrari SH Rahimtoola 2007 Hibernating myocardium: diagnosis and patient outcomes Curr Probl Cardiol 32 375 410
65. RS Beanlands PJ Hendry RG Masters RA Dekemp K Woodend TD Ruddy 1998 Delay in revascularization is associated with increased mortality rate in patients with severe left ventricular dysfunction and viable myocardium on fluorine 18-fluorodeoxyglucose positron emission tomography imaging Circulation 98 II51 II56
66. KG Tarakji R Brunken PM McCarthy MO Al-Chekakie A bdel-Latif CE Pothier 2006 Myocardial viability testing and the effect of early intervention in patients with advanced left ventricular systolic dysfunction Circulation 113 230 237
67. RS Beanlands G Nichol E Huszti D Humen N Racine M Freeman 2007 F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2) J Am Coll Cardiol 50 2002 2012
68. RS Beanlands RA Dekemp S Smith H Johansen TD Ruddy 1997 F-18-fluorodeoxyglucose PET imaging alters clinical decision making in patients with impaired ventricular function Am J Cardiol 79 1092 1095
69. PB Jacklin SF Barrington JC Roxburgh G Jackson D Sariklis PA West 2002 Cost-effectiveness of preoperative positron emission tomography in ischemic heart disease Ann Thorac Surg 73 1403 1409
70. LH Brudin SO Valind CG Rhodes CF Pantin M Sweatman T Jones 1994 Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography Eur J Nucl Med 21 297 305
71. S Ishimaru I Tsujino T Takei E Tsukamoto S Sakaue M Kamigaki 2005 Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis Eur Heart J 26 1538 1543
72. PJ Lewis A Salama 1994 Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis J Nucl Med 35 1647 1649
73. Y Nishiyama Y Yamamoto K Fukunaga H Takinami Y Iwado K Satoh 2006 Comparative evaluation of 18F-FDG PET and 67Ga scintigraphy in patients with sarcoidosis J Nucl Med 47 1571 1576
74. W Okumura T Iwasaki T Toyama T Iso M Arai N Oriuchi 2004 Usefulness of fasting 18F-FDG PET in identification of cardiac sarcoidosis J Nucl Med 45 1989 1998
75. J Meller F Strutz U Siefker A Scheel CO Sahlmann K Lehmann 2003 Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI Eur J Nucl Med Mol Imaging 30 730 736
76. M Webb A Chambers A AL-Nahhas JC Mason L Maudlin L Rahman 2004 The role of 18F-FDG PET in characterising disease activity in Takayasu arteritis Eur J Nucl Med Mol Imaging 31 627 634
77. M Hernandez-Pampaloni V Allada MC Fishbein HR Schelbert 2003 Myocardial perfusion and viability by positron emission tomography in infants and children with coronary abnormalities: correlation with echocardiography, coronary angiography, and histopathology J Am Coll Cardiol 41 618 626
78. S Schroeder S Achenbach F Bengel C Burgstahler F Cademartiri FP de 2008 Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology Eur Heart J 29 531 556
79. AW Leber A Knez ZF von A Becker K Nikolaou S Paul 2005 Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound J Am Coll Cardiol 46 147 154
80. D Ropers U Baum K Pohle K Anders S Ulzheimer B Ohnesorge 2003 Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction Circulation 107 664 666
81. M Hacker T Jakobs F Matthiesen C Vollmar K Nikolaou C Becker 2005 Comparison of spiral multidetector CT angiography and myocardial perfusion imaging in the noninvasive detection of functionally relevant coronary artery lesions: first clinical experiences J Nucl Med 46 1294 1300
82. JD Schuijf W Wijns JW Jukema DE Atsma RA de HJ Lamb 2006 Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging J Am Coll Cardiol 48 2508 2514
83. S Rispler Z Keidar E Ghersin A Roguin A Soil R Dragu 2007 Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions J Am Coll Cardiol 49 1059 1067
84. MF Di Carli S Dorbala Z Curillova RJ Kwong SZ Goldhaber FJ Rybicki 2007 Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging J Nucl Cardiol 14 799 809
85. P Yalamanchili E Wexler M Hayes M Yu J Bozek M Kagan 2007 Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent J Nucl Cardiol 14 782 788
86. M Yu MT Guaraldi M Mistry M Kagan JL McDonald K Drew 2007 BMS-747158-02: a novel PET myocardial perfusion imaging agent J Nucl Cardiol 14 789 798
87. MC Huisman T Higuchi S Reder SG Nekolla T Poethko HJ Wester 2008 Initial characterization of an 18F-labeled myocardial perfusion tracer J Nucl Med 49 630 636
88. I Madar HT Ravert Y Du J Hilton L Volokh RF Dannals 2006 Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium J Nucl Med 47 1359 1366
89. I Madar H Ravert A Dipaula Y Du RF Dannals L Becker 2007 Assessment of severity of coronary artery stenosis in a canine model using the PET agent 18F-fluorobenzyl triphenyl phosphonium: comparison with 99mTc-tetrofosmin J Nucl Med 48 1021 1030
90. PA Kaufmann PG Camici 2005 Myocardial blood flow measurement by PET: technical aspects and clinical applications J Nucl Med 46 75 88
91. CS Duvernoy C Meyer V Seifert-Klauss F Dayanikli I Matsunari J Rattenhuber 1999 Gender differences in myocardial blood flow dynamics: lipid profile and hemodynamic effects J Am Coll Cardiol 33 463 470
92. NG Uren PG Camici JA Melin A Bol BB de J Radvan 1995 Effect of aging on myocardial perfusion reserve J Nucl Med 36 2032 2036
93. P Chareonthaitawee PA Kaufmann O Rimoldi PG Camici 2001 Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans Cardiovasc Res 50 151 161
94. R Campisi J Czernin H Schoder JW Sayre FD Marengo ME Phelps 1998 Effects of long-term smoking on myocardial blood flow, coronary vasomotion, and vasodilator capacity Circulation 98 119 125
95. OP Pitkanen OT Raitakari H Niinikoski P Nuutila H Iida LM Voipio-Pulkki 1996 Coronary flow reserve is impaired in young men with familial hypercholesterolemia J Am Coll Cardiol 28 1705 1711
96. OP Pitkanen P Nuutila OT Raitakari T Ronnemaa PJ Koskinen H Iida 1998 Coronary flow reserve is reduced in young men with IDDM Diabetes 47 248 254
97. G Paternostro PG Camici AA Lammerstma N Marinho RR Baliga JS Kooner 1996 Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography J Clin Invest 98 2094 2099
98. R Lautamaki KE Airaksinen M Seppanen J Toikka R Harkonen M Luotolahti 2006 Insulin improves myocardial blood flow in patients with type 2 diabetes and coronary artery disease Diabetes 55 511 516
99. T Higuchi C Abletshauser SG Nekolla M Schwaiger FM Bengel 2007 Effect of the angiotensin receptor blocker valsartan on coronary microvascular flow reserve in moderately hypertensive patients with stable coronary artery disease Microcirculation 14 1 8
100. FM Bengel C Abletshauser J Neverve O Schnell SG Nekolla E Standl 2005 Effects of nateglinide on myocardial microvascular reactivity in Type 2 diabetes mellitus-a randomized study using positron emission tomography Diabet Med 22 158 163
101. D Neglia C Michelassi MG Trivieri G Sambuceti A Giorgetti L Pratali 2002 Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction Circulation 105 186 193
102. F Cecchi I Olivotto R Gistri R Lorenzoni G Chiriatti PG Camici 2003 Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy N Engl J Med 349 1027 1035
103. TH Schindler EU Nitzsche HR Schelbert M Olschewski J Sayre M Mix 2005 Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events J Am Coll Cardiol 45 1505 1512
104. R Parkash RA Dekemp TD Ruddy A Kitsikis R Hart L Beauchesne 2004 Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease J Nucl Cardiol 11 440 449
105. LL Demer KL Gould RA Goldstein RL Kirkeeide 1990 Noninvasive assessment of coronary collaterals in man by PET perfusion imaging J Nucl Med 31 259 270
106. D Garza AV Tosh R Roberti P Dalal C Reimers F Ongseng 1997 Detection of coronary collaterals using dipyridamole PET myocardial perfusion imaging with rubidium-82 J Nucl Med 38 39 43
107. K Yoshida N Mullani KL Gould 1996 Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia J Nucl Med 37 1701 1712
108. J Machac K Knesaurek H Chen O Almeida BR Krynyckyi C Kim 2003 Validation of a practical method of coronary flow reserve quantification with rubidium-82 myocardial PET perfusion imaging J Nucl Med 44 90P
109. JW Lin RR Sciacca RL Chou AF Laine SR Bergmann 2001 Quantification of myocardial perfusion in human subjects using 82Rb and wavelet-based noise reduction J Nucl Med 42 201 208
110. G El Fakhri A Sitek B Guerin MF Kijewski MF Di Carli SC Moore 2005 Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses J Nucl Med 46 1264 1271
111. E Falk 1992 Why do plaques rupture? Circulation 86 III30 III42
112. JR Davies JH Rudd TD Fryer MJ Graves JC Clark PJ Kirkpatrick 2005 Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging Stroke 36 2642 2647
113. JR Davies JH Rudd PL Weissberg 2004 Molecular and metabolic imaging of atherosclerosis J Nucl Med 45 1898 1907
114. JR Davies JH Rudd PL Weissberg J Narula 2006 Radionuclide imaging for the detection of inflammation in vulnerable plaques J Am Coll Cardiol 47 C57 C68
115. S Ben-Haim E Kupzov A Tamir O Israel 2004 Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT J Nucl Med 45 1816 1821
116. M Ogawa S Ishino T Mukai D Asano N Teramoto H Watabe 2004 (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study J Nucl Med 45 1245 1250
117. JH Rudd EA Warburton TD Fryer HA Jones JC Clark N Antoun 2002 Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography Circulation 105 2708 2711
118. JH Rudd KS Myers S Bansilal J Machac A Rafique M Farkouh 2007 (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials J Am Coll Cardiol 50 892 896
119. A Tawakol RQ Migrino GG Bashian S Bedri D Vermylen RC Cury 2006 In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients J Am Coll Cardiol 48 1818 1824
120. N Tahara H Kai M Ishibashi H Nakaura H Kaida K Baba 2006 Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography J Am Coll Cardiol 48 1825 1831
121. FM Bengel 2006 Atherosclerosis imaging on the molecular level J Nucl Cardiol 13 111 118
122. FM Bengel 2006 Nuclear imaging in cardiac cell therapy Heart Fail Rev 11 325 332
123. M Hofmann KC Wollert GP Meyer A Menke L Arseniev B Hertenstein 2005 Monitoring of bone marrow cell homing into the infarcted human myocardium Circulation 111 2198 2202
124. B Wagner M Anton SG Nekolla S Reder J Henke S Seidl 2006 Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography J Am Coll Cardiol 48 2107 2115