YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea

Journal of Antibiotics

Volumn 57, Issue 9, 2004, Pages 569-572

  Kamigiri, Kazuma ^a   Tanaka, Kouichi ^a   Matsumoto, Hisao ^b   Nagai, Koji ^a   Watanabe, Masato ^a   Suzuki, Kenichi ^a  

^a Clinical Pharmacology Research Laboratories   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIMETHYLAMINO 1 (4 HYDROXYPHENYL) 8,10 DIMETHYL 6 DODECENE 3 ONE; ANTIFUNGAL AGENT; MANNAN; UNCLASSIFIED DRUG; YM 193221;

ANTIFUNGAL ACTIVITY; ARTICLE; ASCOMYCETES; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CARBOHYDRATE SYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CELL WALL; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDALLESCHERIA ELLIPSOIDEA; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET SPECTROPHOTOMETRY; YEAST CELL;

CANDIDA ALBICANS; PSEUDALLESCHERIA ELLIPSOIDEA;

EID: 5044239308     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.569     Document Type: Article

References (12)

1. Nishiyama, Y. & H. Yamaguchi: Mode of action of antifungal agents for treatment of systematic fungal infection. Antibiot. Chemother. 16: 19-26, 2000
2. Maebashi, K.; M. Kudoh, Y. Nishiyama, K. Makimura, Y. Kamai, K. Uchida & H. Yamaguchi: Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibity strains of Candida albicans isolated from a Japanese AIDS patient. Microbiol. Immunol. 47: 117-124, 2003
3. Cid, V. J.; A. Duran, F. D. Rey, M. P. Snyder, C. Nombela & M. Sanchez: Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol. Rev. 59: 345-386, 1995
4. Douglas, L. J. & J. McCourtie: Effect of tunicamycin treatment on the adherence of Candida albicans to human buccal epithelial cells. FEMS Microbiol. Lett. 16: 199-202, 1983
5. Calderone, R. A. & P. Braun: Adherence and receptor relationships of Candida albicans. Microbiol. Rev. 55: 1-20, 1991
6. Chang, Y. C., L. A. Penoyer & K. J. Kwon-Chung: The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence. Infect. Immun. 64: 1977-1983, 1996
7. Ibrahim, A. S.; S. G. Filler, M. S. Alcouloumer, T. R. Kozel, J. E. Edward, Jr. & M. A. Ghannoum: Adherence to and damage of endothelial cells by Cryptococcus neoformans in vitro: role of the capsule. Infect. Immun. 63: 4368-4374, 1995
8. Latge, J.; H. Kobayashi, J. Debeaupuis, M. Diaquin, J. Sarfati, J. Wieruszeski, E. Parra, J. Bouchara & B. Fournet: Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect. Immun. 62: 5424-5433, 1994
9. Penalver, M. C.; J. E. O'Connor, J. P. Martinez & M. L. Gil: Binding of human fibronectin to Aspergillus fumigatus Conidia. Infect. Immun. 64: 1146-1153, 1996
10. Dean, N.: Yeast glycosylation mutants are sensitive to aminoglycosides. Proc. Natl. Acad. Sci. USA 92: 1287-1291, 1995
11. Kume H. & T. Yamazaki: Practical measurement of antifungal activity. (in Japanese) Clinical Microbiology (Japan) 21: 572-580, 1994
12. Nakayama, K.; T. Nagasu, Y. Shima, J. Kuromitsu & Y. Jigame: OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. EMBO J. 11: 2511-2519, 1992