Apolipoprotein e promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: No evidence of association in the Irish population

Irish Journal of Medical Science

Volumn 177, Issue 1, 2008, Pages 29-33

  Lynch, C A ^a   Brazil, J ^b   Cullen, B ^a   Coakley, D ^a   Gill, M ^b   Lawlor, B A ^a   Hawi, Z ^b  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Alzheimer's disease; Apolipoprotein E; Promoter polymorphisms

Indexed keywords

APOLIPOPROTEIN E;

AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION;

AGED; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 50349083512     PISSN: 00211265     EISSN: 18634362     Source Type: Journal    
DOI: 10.1007/s11845-007-0098-7     Document Type: Article

References (21)

1. Diedrich JF, Minnigan H, Carp RI, Whitaker JN, Race R, Frey W 2nd, Haase AT (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J Virol 65(9):4759-4768
2. Corder E, Saunders A, Strittmatter W, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Genetic dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923
3. Saunders A, Strittmatter W, Schmechael D, George-Hyslop P, Perick-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-Maclachlan DR, Alberts MJ et al (1993) Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's Disease. Neurology 43:1467-1472
4. Levy-Lahad E, Lahad A, Wijsman EM, Bird TD, Schellenberg GD (1995) Apolipoprotein E genotypes and age of onset in earlyonset familial Alzheimer's disease. Ann Neurol 38:678-680
5. Hawi Z, Sheehan K, Lynch A, Evans I, Lowe N, Lawlor B, Gill M (2003) Late onset Alzheimer disease and apolipoprotein E (APOE) association in the Irish population: relative risk and attributable fraction. Ir J Med Sci 172 (2):74-76
6. Artiga MJ, Bullido MJ, Frank A, Sastre I, Receuro M, Garcia MA, Lendon CL, Han SW, Morris JC, Vasquez J, Goate A, Valdiviesco F (1998) Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Hum Mol Genet 7(12):1887-1892
7. Bullido MJ, Artiga MJ, Recuero M, Sastre I, Garcia MA, Aldudo J, Lendon C, Han SW, Morris JC, Frank A, Vazquez J, Goate A, Valdivieso F (1998) A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nat Genet 18:69-71
8. Mckhann G, Drachman DM, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS/ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
9. Laws SM, Hone E, Taddei K, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN (2002) Variation at the APOE -491-promoter locus is associated with altered brain levels of apolipoprotein E. Mol Psychiatry 7(8):886-890
10. Zhao JH, Sham PC (2002) Faster allelic association analysis using unrelated subjects. Hum Hered 53(1):36-41
11. Henderson AS, Easteal S, Jorm AF, Mackinnon AJ, Korten AE, Christensen H, Croft L, Jacomb PA (1995) Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample. Lancet 346:1387-1390
12. Bennett C, Crawford F, Osborne A, Diaz P, Hoyne J, Lopez R, Roq Duara R, Rossor M, Mullan M (1995) Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's disease but is not causative. Am J Hum Genet 60(1):1-6
13. Artiga MJ, Bullido MJ, Sastre I, Recuero M, Garcia MA, Aldudo J, Vazquez J, Valdivieso F (1998) Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett 421(2):105-108
14. Roks G, Cruts M, Bullido MJ, Backhovens H, Artiga MJ, Hofman A, Valdivieso F, Van Brockhoven C, Van Duijn C (1998) The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early onset Alzheimer's disease. Neurosci Lett 258:65-68
15. Roks G, Houwing-Duistermaat JJ, Dermaut B, Serneels S, Havekes LM, Hofman A, Breteler MMB, Van Broeckhoven C, Van Duijn CM (2002) Effect of the APOE -491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer's disease: the Rotterdam Study. Am J Med Genet 114:570-573
16. Zurutuza L, Verpillat P, Raux G, Hannequin D, Puel M, Belliard S, Michon A, Pothin Y, Camuzat A, Penet C, Martin C, Brice A, Campion D, Clerget-Darpoux F, Frebourg T (2000) APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population. Eur J Hum Genet 8(9):713-716
17. Wang JC, Kwon MD, Shah P, Morris JC, Goate A (2000) Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease. Neurology 55:1644-1649
18. Lambert JC, Berr C, Pasquier F, Delacourte A, Frigard B, Cottel D, Perez-Tur J, Mouroux V, Mohr M, Cecyre D, Galasko D, Lendon C, Poirier J, Hardy J, Mann D, Amouyel P, Chartier-Harlin MC (1998) Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease. Hum Mol Genet 7(9):1511-1516
19. Bullido MJ, Valdiviesco F (2000) Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease. Microsc Res Tech 50(4):261-267
20. Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA (2001) Haplotype tagging for the identification of common disease genes. Nat Genet 29(2):233-237
21. Town T, Paris D, Fallin D, Duara R, Barker W, Gold M, Crawford F, Mullan M (1998) The -491 A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neurosci Lett 252:95-98