The -491 A/T polymorphism in the regulatory region of the Apolipoprotein E gene and early-onset Alzheimer's disease

Neuroscience Letters

Volumn 258, Issue 2, 1998, Pages 65-68

  Roks, Gerwin ^a   Cruts, Marc ^b   Bullido, Maria J ^c   Backhovens, Hubert ^b   Artiga, Maria J ^c   Hofman, Albert ^a   Valdivieso, Fernando ^c   Van Broeckhoven, Christine ^b   Van Duijn, Cornelia M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Alzheimer's disease; Apolipoprotein E gene; Early onset; Genetic epidemiology; Promoter polymorphism; Regulatory region

Indexed keywords

APOLIPOPROTEIN E;

ALZHEIMER DISEASE; ARTICLE; GENE CONTROL; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; NETHERLANDS; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; SPAIN;

AGE OF ONSET; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CHROMOSOMES, HUMAN, PAIR 19; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MIDDLE AGED; POINT MUTATION; POLYMORPHISM, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 0032545164     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00857-X     Document Type: Article

References (14)

1. Bullido, M.J., Artiga, M.J., Recuero, M., Sastre, I., Garcia, M.A., Aldudo, J., Lendon, C., Han, S.W., Morris, J.C., Frank, A., Vasquez, J., Goate, A. and Valdivieso, F., A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia, Nat. Genet., 18 (1998) 69-71.
2. Chartier-Harlin, M.C., Parfitt, M., Legrain, S., Perez-Tur, J., Brousseau, T., Evans, A., Berr, C., Vidai, O., Roques, P., Gourlet, V., Fruchart, J.C., Delacourte, A., Rossor, M. and Amouyel, P., Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region, Hum. Mol. Genet., 3 (1994) 569-574.
3. Corder, E.H., Saunders, A.M., Risch, N.J., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C. Jr., Rimmler, J.B., Locke, P.A., Conneally, P.M., Schmader, K.E., Small, G.W., Roses, A.D., Haines, J.L. and Pericak-Vance, M.A., Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease, Nat. Genet., 7 (1994) 180-184.
4. Hixson, J.E. and Vernier, D.T., Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal, J. Lipid. Res., 31 (1990) 545-548.
5. Hohman, A., Grobbee, D.E., de Jong, P.T. and van den Ouwenland, F.A., Determinants of disease and disability in the elderly: the Rotterdam Study, Eur. J. Epidemiol., 7 (1991) 403-422.
6. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, 34 (1984) 939-944.
7. Lambert, J.C., Pasquier, F., Cottel, D., Frigard, B., Amouyel, P. and Chartier-Harlin, M.C., A new polymorphism in the APOE promoter associated with increased risk of developing Alzheimer's Dis, Hum. Mol. Genet., 7 (1998) 533-540.
8. Saunders, A.M., Strittmatter, W.J., Schmechel, D., George-Hyslop, P.H., Pericak-Vance, M.A., Joo, S.H., Rosi, B.L., Gusella, J.F., Crapper-MacLachlan, D.R., Alberts, M.J., Hulette, C., Crain, B., Goldgaber, D. and Roses, A.D., Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease, Neurology, 43 (1993) 1467-1472.
9. Slooter, A.J.C. and van Duijn, C.M., Genetic epidemiology of Alzheimer Disease, Epidemiol. Rev., 19 (1997) 107-119.
10. Strittmatter, W.J., Saunders, A.M., Schmechel, D., PericakVance, M., Enghild, J., Salvesen, G.S. and Roses, A.D., Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 1977-1981.
11. Terwilliger, J.D. and Ott, J., Handbook of Human Genetic Linkage, John Hopkins University Press, New York, 1994, 307 p.
12. Town, T., Paris, D., Fallin, D., Duara, R., Barker, W., Gold, M., Crawford, F. and Mullan, M., The -491 A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism, Neurosci. Lett., 252 (1998) 95-98.
13. van Duijn, C.M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L.M., Hofman, A. and Van Broeckhoven, C., Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease, Nat. Genet., 7 (1994) 74-78.
14. van Duijn, C.M., de Knijff, P., Wehnert, A., De Voecht, J., Bronzova, J.B., Havekes, L.M., Hofman, A. and Van Broeckhoven, C., The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival, Ann. Neurol., 37 (1995) 605-610.