Enzyme-based assay for quantification of chlorpyrifos oxon in human plasma

Toxicology Letters

Volumn 181, Issue 1, 2008, Pages 19-24

  Heilmair, Renate ^a   Eyer, Florian ^b   Eyer, Peter ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chlorpyrifos; Chlorpyrifos oxon; Cholinesterases; Poisoning; Pralidoxime

Indexed keywords

ALBUMIN; CHLORPYRIFOS; CHLORPYRIFOS OXON; CHOLINESTERASE; EDETIC ACID; PENTANE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; INTOXICATION; METABOLITE; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE STUDY;

BUTYRYLCHOLINESTERASE; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; HUMANS; PROTEIN BINDING; SERUM ALBUMIN;

EQUIDAE;

EID: 50249108388     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.06.868     Document Type: Article

References (25)

1. Amitai G., Moorad D., Adani R., and Doctor B.P. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem. Pharmacol. 56 (1998) 293-299
2. Baker M., and Parton T. Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake. Xenobiotica 37 (2007) 1110-1134
3. Carr R.L., and Chambers J.E. Kinetic analysis of the in vitro inhibition, aging, and reactivation of brain acetylcholinesterase from rat and channel catfish by paraoxon and chlorpyrifos-oxon. Toxicol. Appl. Pharmacol. 139 (1996) 365-373
4. Choi K., Joo H., Rose R.L., and Hodgson E. Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes. J. Biochem. Mol. Toxicol. 20 (2006) 279-291
5. Drevenkar V., Vasilic Z., Stengl B., Frobe Z., and Rumenjak V. Chlorpyrifos metabolites in serum and urine of poisoned persons. Chem. Biol. Interact. 87 (1993) 315-322
6. Eddleston M., Eyer P., Worek F., Mohamed F., Senarathna L., von Meyer L., Juszczak E., Hittarage A., Azhar S., Dissanayake W., Sheriff M.H., Szinicz L., Dawson A.H., and Buckley N.A. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 366 (2005) 1452-1459
7. Ellman G.L., Courtney K.D., Andres V., and Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
8. Eyer F., and Eyer P. Enzyme-based assay for quantification of paraoxon in blood of parathion poisoned patients. Hum. Exp. Toxicol. 17 (1998) 645-651
9. Eyer F., Meischner V., Kiderlen D., Thiermann H., Worek F., Haberkorn M., Felgenhauer N., Zilker T., and Eyer P. Human parathion poisoning: a toxicokinetic analysis. Toxicol. Rev. 22 (2003) 143-163
10. Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol. Rev. 22 (2003) 165-190
11. Fujioka K., and Casida J.E. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives. Chem. Res. Toxicol. 20 8 (2007) 1211-1217
12. Li B., Schopfer L., Hinrichs S.H., Masson P., and Lockridge O. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr 411. Anal. Biochem. 361 (2007) 263-272
13. Mourik J., and de Jong L.P.A. Binding of the organophosphates parathion and paraoxon to bovine and human serum albumin. Arch. Toxicol. 41 (1978) 43-48
14. Mutch E., Daly A.K., and Williams F.M. The relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver. Drug Metab. Dispos. 35 (2007) 315-320
15. Mutch E., and Williams F.M. Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology 224 (2006) 22-32
16. Peeples E.S., Schopfer L.M., Duysen E.G., Spaulding R., Voelker T., Thompson C.M., and Lockridge O. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol. Sci. 83 (2005) 303-312
17. Rich R.L., Day Y.S., Morton T.A., and Myszka D.G. High-resolution and high-throughput protocols for measuring drug/human serum albumin interactions using BIACORE. Anal. Biochem. 296 (2001) 197-207
18. Rosenfeld C.A., and Sultatos L.G. Concentration-dependent kinetics of acetylcholinesterase inhibition by the organophosphate paraoxon. Toxicol. Sci. 90 (2006) 460-469
19. Sams C., Cocker J., and Lennard M.S. Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Xenobiotica 34 (2004) 861-873
20. Schopfer L.M., Voelker T., Bartels C.F., Thompson C.M., and Lockridge O. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem. Res. Toxicol. 18 (2005) 747-754
21. Sultatos L.G., Shao M., and Murphy S.D. The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos. Toxicol. Appl. Pharmacol. 73 (1984) 60-68
22. Sultatos L.G., Basker K.M., Shao M., and Murphy S.D. The interaction of the phosphorothioate insecticides chlorpyrifos and parathion and their oxygen analogues with bovine serum albumin. Mol. Pharmacol. 26 (1984) 99-104
23. Thiermann H., Mast U., Klimmek R., Eyer P., Hibler A., Pfab R., Felgenhauer N., and Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum. Exp. Toxicol. 16 (1997) 473-480
24. Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., and Mattsson J.L. A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol. Sci. 66 (2002) 34-53
25. Worek F., Mast U., Kiderlen D., Diepold C., and Eyer P. Improved determination of acetylcholinesterase activity in human whole blood. Clin. Chim. Acta 288 (1999) 73-90