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Volumn 225, Issue 7, 2008, Pages 623-628

In vitro studies on the mechanism of action of VEGF and its inhibitors;In-vitro-untersuchungen zum wirkungsmechanismus von VEGF und seinen inhibitoren

Author keywords

Diabetic retinopathy; Retinal microvascular endothelial cells; VEGF; VEGF inhibitors

Indexed keywords

BEVACIZUMAB; PEGAPTANIB; RANIBIZUMAB; VASCULOTROPIN; VASCULOTROPIN 165; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR;

EID: 50149105887     PISSN: 00232165     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1027513     Document Type: Review
Times cited : (6)

References (34)
  • 1
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. NEJM 1994; 331: 1480-1487
    • (1994) NEJM , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 2
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occludens 1
    • Antonetti DA, Barber AJ, Hollinger LA et al. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occludens 1. J Biol Chem 1999; 274: 23463-23467
    • (1999) J Biol Chem , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3
  • 3
    • 33645553318 scopus 로고    scopus 로고
    • Endothelial tight junctions: Permeable barriers of the vessel wall
    • Bazzoni G. Endothelial tight junctions: permeable barriers of the vessel wall. Thromb Haemost 2006; 95: 36-42
    • (2006) Thromb Haemost , vol.95 , pp. 36-42
    • Bazzoni, G.1
  • 4
    • 0037387683 scopus 로고    scopus 로고
    • VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor
    • Behzadian MA, Windsor LJ, Ghaly N et al. VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor. FASEB J 2003; 17: 752-754
    • (2003) FASEB J , vol.17 , pp. 752-754
    • Behzadian, M.A.1    Windsor, L.J.2    Ghaly, N.3
  • 5
    • 0031781305 scopus 로고    scopus 로고
    • VEGF localisation in diabetic retinopathy
    • Boulton M, Foreman D, Williams G et al. VEGF localisation in diabetic retinopathy. Br J Ophthalmol 1998; 82: 561-568
    • (1998) Br J Ophthalmol , vol.82 , pp. 561-568
    • Boulton, M.1    Foreman, D.2    Williams, G.3
  • 6
    • 0346777254 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Caldwell RB, Bartoli M, Behzadian MA et al. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003; 19: 442-455
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 442-455
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 7
    • 21444439235 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: Role of oxidative stress
    • Caldwell RB, Bartoli M, Behzadian MA et al. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets 2005; 6: 511-524
    • (2005) Curr Drug Targets , vol.6 , pp. 511-524
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 8
    • 33644647358 scopus 로고    scopus 로고
    • Generation and characterization of iBREC: Novel hTERT-immortalized bovine retinal endothelial cells
    • Deissler H, Deissler H, Lang GK et al. Generation and characterization of iBREC: novel hTERT-immortalized bovine retinal endothelial cells. Int J Mol Med 2005; 16: 65-70
    • (2005) Int J Mol Med , vol.16 , pp. 65-70
    • Deissler, H.1    Deissler, H.2    Lang, G.K.3
  • 9
    • 39049192230 scopus 로고    scopus 로고
    • TGFβ induces transdifferentiation of iBREC to &alphaSMA-expressing cells
    • Deissler H, Deissler H, Lang GK et al. TGFβ induces transdifferentiation of iBREC to &alphaSMA-expressing cells. Int J Mol Med 2006; 18: 577-582
    • (2006) Int J Mol Med , vol.18 , pp. 577-582
    • Deissler, H.1    Deissler, H.2    Lang, G.K.3
  • 10
    • 45249116797 scopus 로고    scopus 로고
    • VEGF-induced effects on proliferation, migration and tight junctions are restored by ranibizumab (Lucentis®) in microvascular retinal endothelial cells
    • im Druck
    • Deissler H, Deissler H, Lang S et al. VEGF-induced effects on proliferation, migration and tight junctions are restored by ranibizumab (Lucentis®) in microvascular retinal endothelial cells. Br J Ophthalmol 2008; im Druck
    • (2008) Br J Ophthalmol
    • Deissler, H.1    Deissler, H.2    Lang, S.3
  • 11
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 12
    • 33749632278 scopus 로고    scopus 로고
    • Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara N, Damico L, Shams N et al. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006; 26: 859-870
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3
  • 13
    • 0036789145 scopus 로고    scopus 로고
    • Pericytes and the pathogenesis of diabetic retinopathy
    • Hammes H-P, Lin J, Renner O et al. Pericytes and the pathogenesis of diabetic retinopathy. Diabetes 2002; 51: 3107-3112
    • (2002) Diabetes , vol.51 , pp. 3107-3112
    • Hammes, H.-P.1    Lin, J.2    Renner, O.3
  • 14
    • 33947313405 scopus 로고    scopus 로고
    • VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability
    • Harhaj NS, Felinski EA, Wolpert EB et al. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci 2006; 47: 5106-5115
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 5106-5115
    • Harhaj, N.S.1    Felinski, E.A.2    Wolpert, E.B.3
  • 15
    • 1842609550 scopus 로고    scopus 로고
    • Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes
    • Hughes JM, Brink A, Witmer AM et al. Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes. Br J Ophthalmol 2004; 88: 566-572
    • (2004) Br J Ophthalmol , vol.88 , pp. 566-572
    • Hughes, J.M.1    Brink, A.2    Witmer, A.M.3
  • 16
    • 7044228789 scopus 로고    scopus 로고
    • A central role for inflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18: 1450-1452
    • (2004) FASEB J , vol.18 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki, V.2    Le, M.L.3
  • 17
    • 33749028188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathways: Therapeutic perspective
    • Kowanetz M, Ferrara N. Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin Cancer Res 2006; 12: 5018-5022
    • (2006) Clin Cancer Res , vol.12 , pp. 5018-5022
    • Kowanetz, M.1    Ferrara, N.2
  • 18
    • 35148885811 scopus 로고    scopus 로고
    • Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo
    • Lowe J, Araujo J, Yang J et al. Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo. Exp Eye Res 2007; 85: 425-430
    • (2007) Exp Eye Res , vol.85 , pp. 425-430
    • Lowe, J.1    Araujo, J.2    Yang, J.3
  • 19
    • 0031809264 scopus 로고    scopus 로고
    • Adenosine stimulates canine retinal microvascular endothelial cell migration and tube formation
    • Lutty GA, Mathews MK, Merges C et al. Adenosine stimulates canine retinal microvascular endothelial cell migration and tube formation. Curr Eye Res 1998; 17: 594-607
    • (1998) Curr Eye Res , vol.17 , pp. 594-607
    • Lutty, G.A.1    Mathews, M.K.2    Merges, C.3
  • 20
    • 27744514210 scopus 로고    scopus 로고
    • Elevated plasma CD 105 and vitreous VEGF levels in diabetic retinopathy
    • Malik RA, Li C, Aziz W et al. Elevated plasma CD 105 and vitreous VEGF levels in diabetic retinopathy. J Cell Mol Med 2005; 9: 692-697
    • (2005) J Cell Mol Med , vol.9 , pp. 692-697
    • Malik, R.A.1    Li, C.2    Aziz, W.3
  • 21
    • 0029162588 scopus 로고
    • Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid
    • McLeod DS, Lefer DJ, Merges C et al. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol 1995; 147: 642-653
    • (1995) Am J Pathol , vol.147 , pp. 642-653
    • McLeod, D.S.1    Lefer, D.J.2    Merges, C.3
  • 22
    • 34548235938 scopus 로고    scopus 로고
    • Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
    • Pan Q, Chathery Y, Wu Y et al. Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem 2007; 282: 24049-24056
    • (2007) J Biol Chem , vol.282 , pp. 24049-24056
    • Pan, Q.1    Chathery, Y.2    Wu, Y.3
  • 23
    • 34249777252 scopus 로고    scopus 로고
    • Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells
    • Peters S, Julien S, Heiduschka P et al. Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells. Br J Ophthalmol 2007; 91: 827-831
    • (2007) Br J Ophthalmol , vol.91 , pp. 827-831
    • Peters, S.1    Julien, S.2    Heiduschka, P.3
  • 24
    • 0034854865 scopus 로고    scopus 로고
    • VEGF-initiated blood-retinal barrier breakdown in early diabetes
    • Qaum T, Xu Q, Joussen AM et al. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci 2001; 42: 2408-2413
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2408-2413
    • Qaum, T.1    Xu, Q.2    Joussen, A.M.3
  • 25
    • 0036290154 scopus 로고    scopus 로고
    • VEGF and VEGF receptor levels in retinal and brain-derived endlthelial cells
    • Raja TT, Grammas P. VEGF and VEGF receptor levels in retinal and brain-derived endlthelial cells. Bioch Biophys Res Commun 2002; 293: 710-713
    • (2002) Bioch Biophys Res Commun , vol.293 , pp. 710-713
    • Raja, T.T.1    Grammas, P.2
  • 26
    • 0030982357 scopus 로고    scopus 로고
    • Possible involvement of phosphorylation of occludin in tight junction formation
    • Sakakibara A, Furuse M, Saitou M et al. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 1997; 137: 1393-1401
    • (1997) J Cell Biol , vol.137 , pp. 1393-1401
    • Sakakibara, A.1    Furuse, M.2    Saitou, M.3
  • 27
    • 33750285956 scopus 로고    scopus 로고
    • Antiproliferative and cytotoxic properties of bevacizumab on different ocular cells
    • Spitzer MS, Wallenfels-Thilo B, Sierra A et al. Antiproliferative and cytotoxic properties of bevacizumab on different ocular cells. Br J Ophthalmol 2006; 90: 1316-1321
    • (2006) Br J Ophthalmol , vol.90 , pp. 1316-1321
    • Spitzer, M.S.1    Wallenfels-Thilo, B.2    Sierra, A.3
  • 28
    • 35548965345 scopus 로고    scopus 로고
    • Comparative antiproliferative and cytotoxic profile of bevacizumab (Avastin), pegaptanib (Macugen) and ranibizumab (Lucentis) on different ocular cells
    • Spitzer MS, Yoeruek E, Sierra A et al. Comparative antiproliferative and cytotoxic profile of bevacizumab (Avastin), pegaptanib (Macugen) and ranibizumab (Lucentis) on different ocular cells. Graefes Arch Clin Exp Ophthalmol 2007; 245: 1837-1842
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , pp. 1837-1842
    • Spitzer, M.S.1    Yoeruek, E.2    Sierra, A.3
  • 29
    • 0031976812 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells
    • Suzuma K, Takagi H, Otani A et al. Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci 1998; 39: 1028-1035
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1028-1035
    • Suzuma, K.1    Takagi, H.2    Otani, A.3
  • 31
    • 0345827805 scopus 로고    scopus 로고
    • Technology evaluation: Pegaptanib, Eyetech/Pfizer
    • Vinores SA. Technology evaluation: pegaptanib, Eyetech/Pfizer. Curr Opin Mol Ther 2003; 5: 673-679
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 673-679
    • SA, V.1
  • 32
    • 15044347979 scopus 로고    scopus 로고
    • Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy
    • Watanabe D, Suzuma K, Suzuma I et al. Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Am J Ophthalmol 2005; 139: 476-481
    • (2005) Am J Ophthalmol , vol.139 , pp. 476-481
    • Watanabe, D.1    Suzuma, K.2    Suzuma, I.3
  • 33
    • 0036187554 scopus 로고    scopus 로고
    • Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF induced retinopathy in monkey
    • Witmer AN, Blaauwgeers HG, Weich HA et al. Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF induced retinopathy in monkey. Invest Ophthalmol Vis Sci 2002; 43: 849-857
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 849-857
    • Witmer, A.N.1    Blaauwgeers, H.G.2    Weich, H.A.3
  • 34
    • 0031425958 scopus 로고    scopus 로고
    • Phosphorylation of occludin correlates with occludin localization and funciton at the tight junction
    • Wong V. Phosphorylation of occludin correlates with occludin localization and funciton at the tight junction. Am J Physiol 1997; 273: C1859-1867
    • (1997) Am J Physiol , vol.273
    • Wong, V.1


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