Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Medicinal Chemistry

Volumn 4, Issue 4, 2008, Pages 392-395

  Harpstrite, Scott E ^a   Collins, Silvia D ^a   Oksman, Ana ^b   Goldberg, Daniel E ^b   Sharma, Vijay ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimalarials; Chloroquine resistance; Naphthalene amine; P. falciparum; Schiff base phenol

Indexed keywords

2 [[5 (DIETHYLAMINO)PENTAN 2 YLAMINO]METHYL] 4 BROMO 6 METHOXYPHENOL; 2 [[5 (DIETHYLAMINO)PENTAN 2 YLAMINO]METHYL] 6 METHOXYPHENOL; 2 [[5 (DIETHYLAMINO)PENTAN 2 YLIMINO]METHYL] 4 BROMO 6 METHOXYPHENOL; 2 [[5 (DIETHYLAMINO)PENTAN 2 YLIMINO]METHYL] 5 (DIETHYLAMINO)PHENOL; 2 [[5 (DIETHYLAMINO)PENTAN 2 YLIMINO]METHYL] 6 METHOXYPHENOL; 4 [[5 (DIETHYLAMINO)PENTAN 2 YLAMINO]METHYL] N,N DIMETHYLNAPHTHALEN 1 AMINE; 4 [[5 (DIETHYLAMINO)PENTAN 2 YLIMINO]METHYL] N,N DIMETHYLNAPHTHALEN 1 AMINE; AMINE; ANTIMALARIAL AGENT; CHLOROQUINE; NAPHTHALENE DERIVATIVE; PHENOL DERIVATIVE; SCHIFF BASE;

ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TROPHOZOITE;

AMINES; ANIMALS; ANTIMALARIALS; LIGANDS; MOLECULAR STRUCTURE; NAPHTHALENES; PHENOL; PLASMODIUM FALCIPARUM; SCHIFF BASES;

EID: 50049129392     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608784872280     Document Type: Article

References (24)

1. Wellems, T. Science, 2002, 298, 124.
2. Sharma, V. Mini Rev. Med. Chem., 2005, 5, 337.
3. Ziegler, J.; Linck, R.; Wright, D. Curr. Med. Chem., 2001, 8(2), 171.
4. Sharma, V.; Piwnica-Worms, D. Chem. Rev., 1999, 99, 2545.
5. Ocheskey, J.; Harpstrite, S.; Oksman, A.; Goldberg, D.; Sharma, V. Chem. Commun., 2005, 1622.
6. MacArthur, J.; Stennies, G.; Macheso, A.; Kolczak, M.; Green, M.; Ali, D.; Barat, L.; Kazembe, P.; RueBush, T. Am. J. Trop. Med. Hyg., 2001, 6, 679.
7. Udry, E.; Bailly, F.; Dusmet, M.; Schnyder, P.; Lemoine, R.; Fitting, J. Eur. Respir. J., 2001, 18(5), 890.
8. Kang, J.; Chen, X.; Wang, L.; Rampe, D. J. Pharmacol. Exp. Ther., 2001, 299 (1), 290.
9. Wesche, D.; Schuster, B.; Wang, W.; Woosley, R. Clin. Pharmacol. Ther., 2000, 67(5), 521.
10. Hogh, B.; Clarke, P.; Camus, D.; Nothdurft, D.; Overbosch, D.; Gunther, M.; Joubert, I.; Kain, K.; Shaw, D.; Roskell, N.; Chulay, J. Lancet, 2000, 356(9245), 1888.
11. Van Vugt, M.; Looareesuwan, S.; Wilairatana, P.; McGready, R.; Villegas, L.; Gathmann, I.; Mull, R.; Brockman, A.; White, N.; Nosten, F. Trans. R. Soc. Trop. Med. Hyg., 2000, 94(5), 545.
12. Winstanley, P.; Ward, S.; Snow, R. Microbes Infect., 2002, 4(2), 157.
13. Goldberg, D. E.; Sharma, V.; Oksman, A.; Gluzman, I. Y.; Wellems, T. E.; Piwnica-Worms, D. J. Biol. Chem., 1997, 272, 6567.
14. Sharma, V.; Beatty, A.; Goldberg, D. E.; Piwnica-Worms, D. J. Chem. Soc. Chem. Commun., 1997, 2223.
15. Ocheskey, J.; Polyakov, V.; Harpstrite, S.; Oksman, A.; Goldberg, D.; Piwnica-Worms, D.; Sharma, V. J. Inorg. Biochem., 2002, 92, 265.
16. Harpstrite, S.; Beatty, A.; Collins, S.; Oksman, A.; Goldberg, D.; Sharma, V. Inorg. Chem., 2003, 42, 2294.
17. Hempelmann, E.; Egan, T. Trends Parasitol., 2002, 18(1), 11.
18. Pagola, S.; Stephens, P.; Bohle, D.; Kosar, A.; Madsen, S. Nature, 2000, 404, 307.
19. Sharma, V.; Crankshaw, C.; Piwnica-Worms, D. J. Med. Chem., 1996, 39, 3483.
20. Wong, E.; Liu, S.; Lugger, T.; Hahn, F. E.; Orvig, C. Inorg. Chem., 1995, 34, 93.
21. Desjardins, R. E.; Canfield, R. J.; Haynes, J. D.; Chulay, J. D. Antimicrob. Agents Chemother., 1979, 16, 710.
22. Egan, T.; Marques, H. Coord. Chem. Rev., 1999, 190-192, 493.
23. Trager, W.; Jensen, J. B., Science, 1976, 193, 673.
24. Lambros, C.; Vanderberg, J. J. Parasitol., 1979, 65, 418.