Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method

Pharmacology and Therapeutics

Volumn 119, Issue 2, 2008, Pages 133-140

  Fossa, Anthony A ^a  

^a ICARDIAC TECHNOLOGIES INC   (United States)

Author keywords

Arrhythmia; Autonomic tone; Bazett formula corrected QT interval; beat to beat QT interval; beats per minute; BPM; ECG; Electrocardiogram; electrocardiogram; Fridericia formula corrected QT interval; IKr; IKs; pharmacokinetic; PK; QTbtb; QTcB; QTcF; rapid potassium delayed rectifier current; Restitution; slow potassium delayed rectifier current; Torsades de pointes; Translation to humans

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; CISAPRIDE; DELAYED RECTIFIER POTASSIUM CHANNEL; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; TERFENADINE; TERODILINE; VERAPAMIL;

AUTONOMIC NERVOUS SYSTEM; BRADYCARDIA; CONSCIOUSNESS LEVEL; DOG; DRUG BLOOD LEVEL; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; HEART BEAT; HEART REPOLARIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; REVIEW; RR INTERVAL; VALIDATION PROCESS;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; DOGS; ELECTROCARDIOGRAPHY; HUMANS; LONG QT SYNDROME; PHARMACEUTICAL PREPARATIONS; SPECIES SPECIFICITY;

EID: 50049124432     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2008.02.013     Document Type: Review

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