A simple entry to novel spiro dihydroquinoline-oxindoles using Povarov reaction between 3-N-aryliminoisatins and isoeugenol

Tetrahedron Letters

Volumn 49, Issue 41, 2008, Pages 5855-5857

  Kouznetsov, Vladimir V ^a   Bello Forero, Josué S ^a   Amado Torres, Diego F ^a  

^a UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

Author keywords

Dihydrospiro indoline 3,2 quinoline 2 ones; Imino Diels Alder cycloaddition; Isatin; Isoeugenol

Indexed keywords

4' (4 HYDROXY 3 METHOXYPHENYL) 3' METHYL 3',4' DIHYDRO 1'H SPIRO(INDOLINE 3,2' QUINOLIN) 2 ONE; EUGENOL; INDOLE DERIVATIVE; OXINDOLE; QUINOLINE DERIVATIVE; SPIRO DIHYDROQUINOLINE OXINDOLE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CYCLOADDITION; DIELS ALDER REACTION; POVAROV REACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALNUS;

EID: 50049108112     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.07.096     Document Type: Article

References (31)

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23. General experimental procedure for the synthesis of the ketimine 9b in PEG 400: In a round-bottom flask, the isatin 7 (2.04 mmol) was dissolved in PEG 400 (5 mL) and the arylamine 8 b was added (2.44 mmol) stirring and heating at 80 °C for 3 h. The product formation is monitored by TLC comparing to the standard protocol of ketimine.
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25. 3: C, 74.98; H, 6.04; N, 7.00. Found: C, 74.74; H, 6.23; N, 7.13.
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