Chronic ethanol exposure increases the association of hippocampal mu-opioid receptors with G-protein receptor kinase 2

Alcohol

Volumn 42, Issue 6, 2008, Pages 493-497

  Saland, Linda C ^a   Chavez, Juliana B ^a   Lee, David C ^a   Garcia, Raphael R ^a   Caldwell, Kevin K ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic ethanol; G protein receptor kinase; Immunoprecipitation; Opioid receptors

Indexed keywords

DELTA OPIATE RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; MU OPIATE RECEPTOR; NALTREXONE; POLYCLONAL ANTIBODY;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; HIPPOCAMPUS; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LONG TERM EXPOSURE; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SPRAGUE DAWLEY RAT;

ALCOHOL DRINKING; ANIMALS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HIPPOCAMPUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 50049091972     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2008.06.002     Document Type: Article

References (22)

1. Becker A., Grecksch G., Kraus J., Loh H.H., Schroeder H., and Hollt V. Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn Schmiedebergs Arch. Pharmacol 365 (2002) 296-302
2. Chen F., and Lawrence A.J. Effect of chronic ethanol and withdrawal on the mu-opioid receptor- and 5-Hydroxytryptamine(1A) receptor-stimulated binding of [(35)S]Guanosine- 5'-O-(3-thio)triphosphate in the fawn-hooded rat brain: a quantitative autoradiography study. J. Pharmacol. Exp. Ther 293 (2000) 159-165
3. Fan X., Zhang J., Zhang X., Yue W., and Ma L. Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain. Neuropharmacology 43 (2002) 809-816
4. Ferreira V.M., Frausto S., Browning M.D., Savage D.D., Morato G., and Valenzuela C.F. Ionotropic glutamate receptor subunit expression in the rat hippocampus: lack of an effect of a long-term ethanol exposure paradigm. Alcohol. Clin. Exp. Res 25 (2001) 1536-1541
5. Ferrer-Alcon M., La Harpe R., and Garcia-Sevilla J.A. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Brain Res. Mol. Brain Res 121 (2004) 114-122
6. Froehlich J.C. Opioid peptides. Alcohol Health Res. World 21 (1997) 132-136
7. Froehlich J.C., Badia-Elder N.E., Zink R.W., McCullough D.E., and Portoghese P.S. Contribution of the opioid system to alcohol aversion and alcohol drinking behavior. J. Pharmacol. Exp. Ther 287 (1998) 284-292
8. Gianoulakis C. Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr. Top. Med. Chem 4 (2004) 39-50
9. Herz A. Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129 (1997) 99-111
10. Hurle M.A. Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity. J. Neurochem 77 (2001) 486-492
11. Law P.Y., and Loh H.H. Regulation of opioid receptor activities. J. Pharmacol. Exp. Ther 289 (1999) 607-624
12. Lieber C.S., and DeCarli L.M. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol. Clin. Exp. Res 6 (1982) 523-531
13. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem 193 (1951) 265-275
14. McLaughlin J.P., Myers L.C., Zarek P.E., Caron M.G., Lefkowitz R.J., Czyzyk T.A., et al. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J. Biol. Chem 279 (2004) 1810-1818
15. Narita M., Miyoshi K., and Suzuki T. Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat. Neuroscience 144 (2007) 777-782
16. Roberts A.J., Gold L.H., Polis I., McDonald J.S., Filliol D., Kieffer B.L., et al. Increased ethanol self-administration in delta-opioid receptor knockout mice. Alcohol. Clin. Exp. Res 25 (2001) 1249-1256
17. Roberts A.J., McDonald J.S., Heyser C.J., Kieffer B.L., Matthes H.W., Koob G.F., et al. mu-Opioid receptor knockout mice do not self-administer alcohol. J. Pharmacol. Exp. Ther 293 (2000) 1002-1008
18. Saland L.C., Abeyta A., Frausto S., Raymond-Stintz M., Hastings C.M., Carta M., et al. Chronic ethanol consumption reduces delta-and mu-opioid receptor-stimulated G-protein coupling in rat brain. Alcohol. Clin. Exp. Res 28 (2004) 98-104
19. Saland L.C., Hastings C.M., Abeyta A., and Chavez J.B. Chronic ethanol modulates delta and mu-opioid receptor expression in rat CNS: immunohistochemical analysis with quantitative confocal microscopy. Neurosci. Lett 381 (2005) 163-168
20. Sim-Selley L.J., Sharpe A.L., Vogt L.J., Brunk L.K., Selley D.E., and Samson H.H. Effect of ethanol self-administration on mu- and delta-opioid receptor-mediated G-protein activity. Alcohol. Clin. Exp. Res 26 (2002) 688-694
21. Soini S.L., Hyytia P., and Korpi E.R. Brain regional mu-opioid receptor function in rat lines selected for differences in alcohol preference. Eur. J. Pharmacol 448 (2002) 157-163
22. Wang Z.J., and Wang L.X. Phosphorylation: a molecular switch in opioid tolerance. Life Sci 79 (2006) 1681-1691