Defective MHC class I antigen surface expression promotes cellular survival through elevated ER stress and modulation of p53 function

Cell Death and Differentiation

Volumn 15, Issue 9, 2008, Pages 1364-1374

  Sabapathy, K ^a,b,c   Nam, S Y ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CARRIER PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN P53; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL NUCLEUS; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR ESCAPE; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; ENDOPLASMIC RETICULUM; GENE DELETION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MUTAGENS; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 49949117469     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2008.55     Document Type: Article

References (39)

1. Janeway Jr CA. The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory. Immunol Res 1999; 19: 107-118.
2. David-Watine B, Israel A, Kourilsky P. The regulation and expression of MHC class I genes. Immunol Today 1990; 11: 286-292.
3. Elliott T, Williams A. The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex. Immunol Rev 2005; 207: 89-99.
4. Groothuis TA, Griekspoor AC, Neijssen JJ, Herberts CA. Neefjes JJ. MHC class I alleles and their exploration of the antigen-processing machinery. Immunol Rev 2005; 207: 60-76.5.
5. Flutter B, Gao B. MHC class I antigen presentation - recently trimmed and well presented. Cell Mol Immunol 2004; 1: 22-30.
6. Garrido F, Algarra I. MHC antigens and tumor escape from immune surveillance. Adv Cancer Res 83: 117-158.
7. Hui KM. Re-expression of major histocompatibility complex (MHC) class I molecules on malignant tumor cells and its effect on host-tumor interaction. Bioessays 1989; 11: 22-26.
8. Singer DS, Mozes E, Kirshner S, Kohn LD. Role of MHC class I molecules in autoimmune disease. Crit Rev Immunol 1997: 17: 463-468.
9. Allison J. Campbell IL, Morahan G, Mandel TE, Harrison LC. Miller JFAP. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 1998: 333: 529-533.
10. Frauman A, Chu P, Harrisson LC. Nonimmune thyroid destruction results from transgenic overexpression of an allogeneic major histocompatibility complex class I protein. Mol Cell Biol 1993: 13: 1554-1564.
11. Jaffe L, Robertson EJ, Bikoff EK. Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens. Proc Nat Acad Sci 1992; 89: 5927-5931.
12. Martin WD, Egan RM, Stevens JL, Woodward JG. Lens-specific expression of a major histocompatibility complex class I molecule disrupts normal lens development and induces cataracts in transgenic mice. Invest Ophthalmol Vis Sci 1995; 36: 1144-1154.
13. Turnley AM, Morahan G, Okano H, Bernard O, Mikoshiba K, Allison J et al. Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature 1991; 353: 566-569.
14. Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, Jaenisch R. Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature 1990; 344: 742-746.
15. Anichini A, Ress S, Strassmann G, Bach FH. Inhibition of anti-class I cytotoxicity by anti-class II monoclonal antibodies (MoAb). II. Blocking of anti-class I CTL clones by anti-DR MoAb. Hum Immunol 1985; 13: 139-143.
16. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408: 307-310.
17. Moll UM, LaQuaglia M, Benard J, Riou G. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995; 92: 4407-4411.
18. Qu L, Huang S, Baltzis D, Rivas-Estilla AM, Pluquet O, Hatzoglou M et al. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 2004; 8: 261-277.
19. Li J, Lee AS. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 2006; 6: 45-54.
20. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M et al. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 2000; 20: 6755-6767.
21. Calfon M, Zang H, Urano F, Till JH, Hubbard SR, Harding HP et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96.
22. Harding HF, Zhang Y. Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397 271-274.
23. Day PM, Esquivel F, Lukszo J, Bennink JR, Yewdell JW. Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules. Immunity 1995; 2 137-147.
24. Martien van Santen H, Woolsey A, Rickardt PG, Van Kaer L, Baas EJ, Berns A et al. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J Exp Med 1995; 181: 787-792.
25. Bernards R, Dessain SK, Weinberg RA. N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell 1986; 47: 667-674.
26. Yamit-Hezi A, Plaksin D, Eisenbach L. c-fos and c-jun overexpression in malignant cells reduces their tumorigenic and metastatic potential, and affects their MHC class I gene expression. Oncogene 1994; 9: 1065-1079.
27. Yuan J, Glazer PM. Mutagenesis induced by the tumor microenvironment. Mutat Res 1998; 400: 439-446.
28. Linda H, Hammarberg H, Piehl F, Khademi M, Olsson T. Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons. J Neuroimmunol 1999; 101: 76-86.
29. Finsen BR, Jorgensen MB, Diemer NH, Zimmer J. Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus. Glia 1993; 7: 41-49.
30. Watson NF, Ramage JM, Madjd Z, Spendlove I, Ellis IO, Scholefield JH et al. Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis. Int J Cancer 2006; 118: 6-10.
31. Fernandez PM, Tabbara SO, Jacobs LK, Manning FC, Tsangaris TN, Schwartz AM et al. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res Treat 2000; 59: 15-26.
32. Lee E, Nichols P, Spicer D, Groshen S, Yu MC, Lee AS. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Can Res 2006; 66: 7849-7853.
33. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: Role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 2003; 278 20915-20924.
34. Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K et al. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 2003; 38: 605-614.
35. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003; 23: 7198-7209.
36. Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H et al XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004; 64: 5943-5947.
37. Li XA, Lee AS. Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment. Mol Cell Biol 1991; 11: 3446-3453.
38. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 2004; 15: 713-725.
39. Lee MK, Hande MP, Sabapathy K. Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis. J Cell Sci 2005; 118: 819-829.