Optimization of iontophoretic parameters for the transdermal delivery of methotrexate

Drug Delivery

Volumn 15, Issue 7, 2008, Pages 437-442

  Vemulapalli, Viswatej ^a   Banga, Ajay K ^a   Friden, Phillip M ^b  

^a MERCER UNIVERSITY   (United States)

^b Transport Pharmaceuticals   (United States)

Author keywords

Factorial Design; Iontophoresis; Methotrexate; Transdermal Drug Delivery

Indexed keywords

METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITY; DRUG DELIVERY SYSTEM; ELECTROCHEMISTRY; FACTORIAL DESIGN; HAIRLESS RAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IONIC STRENGTH; IONTOPHORESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPONSE SURFACE METHOD;

ADMINISTRATION, CUTANEOUS; ANIMALS; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; DRUG DELIVERY SYSTEMS; FOLIC ACID ANTAGONISTS; HYDROGEN-ION CONCENTRATION; IONTOPHORESIS; MALE; METHOTREXATE; OSMOLAR CONCENTRATION; PERMEABILITY; RATS; RATS, HAIRLESS; SKIN; SKIN ABSORPTION; TIME FACTORS;

EID: 49949111645     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540802035145     Document Type: Article

References (17)

1. Al-Khalili, M., Meidan, V. M., and Michniak, B. B. 2003. Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS Pharm. Sci. 5(2):14.
2. Alvarez-Figueroa, M. J., Delgado-Charro, M. B., and Blanco-Mendez, J. 2001. Passive and iontophoretic transdermal penetration of methotrexate. Int. J. Pharm. 212:101-107.
3. Alvarez-Figueroa, M. J., and Blanco-Mendez, J. 2001. Transdermal delivery of methotrexate: iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int. J. Pharm. 215:57-65.
4. Banga, A. K. 1998. Electrically Assisted Transdermal and Topical Drug Delivery, London, UK: Taylor & Francis.
5. Chatterjee, D. J., Li, W. Y., Koda, R. T. 1997. Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin. Pharm. Res. 14:1058-1064.
6. Gazelius, B., 2008 'Iontophoresis-theory.' Perimed: http://www.perimed. se/p_Products/IontophoresisTheory.pdf#search=%22iontophoresis%20theory%22 (accessed 3 January 2008).
7. Kalia, Y. N., Naik, A., Garrison, J., and Guy, R. H., 2004. Iontophoretic drug delivery. Adv, Drug Del. Rev. 56:619-658.
8. Manabe, E., Numajiri, S., Sugibayashi, K., and Morimoto, Y. 2000. Analysis of skin permeation-enhancing mechanism of iontophoresis using hydrodynamic pore theory. J. Control. Rel. 66:149-158.
9. Pikal, M. J., 2001. The role of electro-osmotic flowin transdermal iontophoresis. Adv. Drug Deliv. Rev. 46:281-305.
10. Rekhi, G. S., Nellore, R. V., Hussain, A. S., Tillman, L. G., Malinowski, H. J., and Augusburger, L. L. 1999. Identification of critical formulation and processing variables for metoprolol tartarate extended-release (ER) matrix tablets. J. Control. Rel. 59:327-342.
11. Stagni, G., and Shukla, C. 2003. Pharmacokinetics of methotrexate in rabbit skin and plasma after iv-bolus and iontophoretic administrations, J. Control. Rel. 93:283-292.
12. Sutton, L., Swinehart, J. M., Cato, A., and Kaplan, A. S. 2001. A clinical study to determine the efficacy and safety of 1% methotrexate/ Azone® (MAZ) gel applied topically once daily in patients with psoriasis vulgaris. Int. J. Derm. 40:464-467.
13. Tiwari, S. B., Kumar, B. C., Udupa, N., and Balachandran, C. 2003. Topical methotrexate delivered by iontophoresis in the treatment of recalcitrant psoriasis - a case report. Int. J. Derm. 42:157-159.
14. Upasani, R. S., and Banga, A. K. 2004. Response surface methodology to investigate the iontophoretic delivery of tacrine hydrochloride. Pharm. Res. 21:2293-2299.
15. Vaidyanathan, R., Chaubal, M. G., and Vassavada, R. C. 1985. Effect of pH and solubility on in vitro skin penetration of methotrexate from a 50% v/v propylene glycol-water vehicle. Int. J. Pharm. 25:85-93.
16. Vemulapalli, V., Yang, Y., Friden, P., and Banga, A. K. 2008. Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate. J. Pharm. Pharmacol. 60:27-33.
17. Wong, T. W., Zhao, V. L., Sen, A., and Hui, S. W. 2005. Pilot study of topical delivery of methotrexate by electroporation. Br. J. Derm. 152:524-530.