Bacterial actin: Architecture of the ParMRC plasmid DNA partitioning complex

EMBO Journal

Volumn 27, Issue 16, 2008, Pages 2230-2238

  Salje, Jeanne ^a   Löwe, Jan ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Actin; DNA segregation; ParM; ParR; Plasmid partitioning

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; DIMER; DNA; MONOMER; PAR C PROTEIN; PAR M PROTEIN; PAR R PROTEIN; PLASMID DNA; PROTEIN;

ARTICLE; CHEMICAL ANALYSIS; DIMERIZATION; ELECTRON MICROSCOPY; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY;

ACTINS; DNA TOPOISOMERASE IV; DNA, BACTERIAL; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; PEPTIDES; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

BACTERIA (MICROORGANISMS); PROKARYOTA;

EID: 49949085338     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.152     Document Type: Article

References (24)

1. Campbell CS, Mullins RD (2007) In vivo visualization of type II plasmid segregation: bacterial actin filaments pushing plasmids. J Cell Biol 179: 1059-1066
2. Dam M, Gerdes K (1994) Partitioning of plasmid R1. Ten direct repeats flanking the parA promoter constitute a centromere-like partition site parC, that expresses incompatibility. J Mol Biol 236: 1289-1298
3. Ebersbach G, Gerdes K (2004) Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell. Mol Microbiol 52: 385-398
4. Ebersbach G, Gerdes K (2005) Plasmid segregation mechanisms. Annu Rev Genet 39: 453-479
5. Garner EC, Campbell CS, Mullins RD (2004) Dynamic instability in a DNA-segregating prokaryotic actin homolog. Science 306: 1021-1025
6. Garner EC, Campbell CS, Weibel DB, Mullins RD (2007) Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog. Science 315: 1270-1274
7. Gerdes K, Molin S (1986) Partitioning of plasmid R1. Structural and functional analysis of the parA locus. J Mol Biol 190: 269-279
8. Gerdes K, Møller-Jensen J, Bugge Jensen R (2000) Plasmid and chromosome partitioning: surprises from phylogeny. Mol Microbiol 37: 455-466
9. Gerdes K, Møller-Jensen J, Ebersbach G, Kruse T, Nordström K (2004) Bacterial mitotic machineries. Cell 116: 359-366
10. Ghosh SK, Hajra S, Paek A, Jayaram M (2006) Mechanisms for chromosome and plasmid segregation. Annu Rev Biochem 75: 211-241
11. Goode BL, Eck MJ (2007) Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem 76: 593-627
12. Jensen RB, Lurz R, Gerdes K (1998) Mechanism of DNA segregation in prokaryotes: replicon pairing by parC of plasmid R1. Proc Natl Acad Sci USA 95: 8550-8555
13. Møller-Jensen J, Borch J, Dam M, Jensen RB, Roepstorff P, Gerdes K (2003) Bacterial mitosis: ParM of plasmid R1 moves plasmid DNA by an actin-like insertional polymerization mechanism. Mol Cell 12: 1477-1487
14. Møller-Jensen J, Jensen RB, Löwe J, Gerdes K (2002) Prokaryotic DNA segregation by an actin-like filament. EMBO J 21: 3119-3127
15. Møller-Jensen J, Ringgaard S, Mercogliano CP, Gerdes K, Löwe J (2007) Structural analysis of the ParR/parC plasmid partition complex. EMBO J 26: 4413-4422
16. Nordström K, Molin S, Aagaard-Hansen H (1980) Partitioning of plasmid R1 in Escherichia coli. I. Kinetics of loss of plasmid derivatives deleted of the par region. Plasmid 4: 215-227
17. Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH (2007) The structure of bacterial ParM filaments. Nat Struct Mol Biol 14: 921-926
18. Pogliano J, Ho TQ, Zhong Z, Helinski DR (2001) Multicopy plasmids are clustered and localized in Escherichia coli. Proc Natl Acad Sci USA 98: 4486-4491
19. Popp D, Narita A, Oda T, Fujisawa T, Matsuo H, Nitanai Y, Iwasa M, Maeda K, Onishi H, Maeda Y (2008) Molecular structure of the ParM polymer and the mechanism leading to its nucleotidedriven dynamic instability. EMBO J 27: 570-579
20. Ringgaard S, Ebersbach G, Borch J, Gerdes K (2007) Regulatory cross-talk in the double par locus of plasmid pB171. J Biol Chem 282: 3134-3145
21. Schumacher MA, Glover TC, Brzoska AJ, Jensen SO, Dunham TD, Skurray RA, Firth N (2007) Segrosome structure revealed by a complex of ParR with centromere DNA. Nature 450: 1268-1271
22. Sherratt DJ (2003) Bacterial chromosome dynamics. Science 301: 780-785
23. van den Ent F, Møller-Jensen J, Amos LA, Gerdes K, Löwe J (2002) F-actin-like filaments formed by plasmid segregation protein ParM. EMBO J 21: 6935-6943
24. Weitao T, Dasgupta S, Nordström K (2000) Plasmid R1 is present as clusters in the cells of Escherichia coli. Plasmid 43: 200-204