Transcriptional down-regulation of the human α2C-adrenergic receptor by cAMP

Molecular Pharmacology

Volumn 58, Issue 4, 2000, Pages 821-827

  Schaak, Stéphane ^a   Cayla, Cécile ^a   Lymperopoulos, Anastasios ^b   Flordellis, Christodoulos ^b   Cussac, Daniel ^a   Denis, Colette ^a   Paris, Hervé ^a  

^a CHU RANGUEIL   (France)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DACTINOMYCIN; DEXAMETHASONE; FORSKOLIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHENTOLAMINE; PHORBOL 13 ACETATE 12 MYRISTATE; RECOMBINANT HUMAN INSULIN; TRITIUM;

ADRENERGIC SYSTEM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; MEMBRANE BINDING; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

EID: 0033807385     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.4.821     Document Type: Article

References (32)

1. Localization of messenger RNA for three distinct α2-adrenergic receptor subtypes in human tissues. Evidence for species heterogeneity and implication for human pharmacology
2. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. International Union of Pharmacology nomenclature of adrenoceptors
4. Homologous regulation of the α2C-adrenoceptor subtype in human hepatocarcinoma, HepG2
5. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
6. Structure and regulation of G protein-coupled receptors: The β2-adrenergic receptor as a model
7. Regulation of the α2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors
8. Regional distribution of α2A- and α2B-adrenoceptor subtypes in postmortem human brain
9. Subtype-selective desensitization of α2-adrenergic receptors. Different mechanisms control short and long term agonist promoted desensitization of α2C10, α2C4 and α2C2
10. Differential regulation by tumor necrosis factor-α of β1-, β2, and β3-adrenoceptor gone expression in 3T3-F442A adipocytes
11. Regulation of α2-adrenegic receptor expression and signaling in pancreatic β-cells
12. G protein-coupled receptor kinase specificity for phosphorylation and desensitization of α2-adrenergic receptor subtypes
13. Cloning, sequencing, and expression of the gone coding for the human platelet α2-adrenergic receptor
14. Cardiovascular regulation in mice lacking α2-adrenergic receptor subtypes b and c
15. Expansion of the α2-adranergic receptor family: Cloning and characterization of a human α2-adrenergic receptor subtype, the gone for which is located on chromosome 2
16. Central hypotensive effects of the α2A-adrenergic receptor subtype
17. Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC
18. Cyclic AMP-mediated inhibition of transcription of the malic enzyme gone in chick embryo hepatocytes in culture. Characterization of a cis-acting element far upstream of the promoter
19. Differential expression of two α2-adrenergic receptor subtype mRNAs in human tissues
20. 3H]L-657,743 (MK-912): A new, high affinity, selective radioligand for brain α2-adranoceptors
21. Rythmic variation in β1-adrenergic receptor mRNA levels in the rat pineal gland: Circadian and developmental regulation
22. Cloning and expression of a human kidney eDNA for an α2-adrenergic receptor subtype
23. Regulation of α2A-adrenergic receptor mRNA in rat astroglial cultures: Role of cyclic AMP and protein kinase C
24. Insulin down-regulates alpha-2 adrenergic receptors in cultured glial cells
25. Pharmacologic and therapeutic application of α2-adrenoceptor subtypes
26. cAMP regulates transcription of the α2A adrenergic receptor gone in HT-29 cells
27. HepG2 and SK-N-MC: Two human models to study α2-adrenergic receptors of the α2C-subtype
28. Molecular cloning, sequencing and functional study of the promoter region of the human α2C4-adrenergic receptor gone
29. Rapid detection of octamer binding proteins with 'mini-extracts' prepared from a small number of cells
30. Cyclic AMP inhibits phosphatidylinositol-coupled and -uncoupled mitogenic signals in T lymphocytes. Evidence that cAMP alters PKC-induced transcription regulation of members of the jun and fos family of genes
31. Subtype-specific differences in the intracellular sorting of G protein-coupled receptors