Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4876-4879

  Brown, Neil ^a,b   Xie, Baohan ^a   Markina, Nataliya ^a   VanderVelde, David ^b   Perchellet, Jean Pierre H ^c   Perchellet, Elisabeth M ^a,c   Crow, Kyle R ^c   Buszek, Keith R ^a,b  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Eight membered; Lactam; Library; Medium ring; Natural product; Octalactin; Parallel synthesis; Ring closing metathesis

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; DAUNORUBICIN; LACTAM DERIVATIVE; MITOXANTRONE; NATURAL PRODUCT; OCTALACTIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RING CLOSING METATHESIS;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CELL PROLIFERATION; HL-60 CELLS; HUMANS; LACTAMS; LACTONES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM;

EID: 49849100783     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.074     Document Type: Article

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