Racemic, S(+)- and R(-)-ketamine do not increase elevated intracranial pressure

Acta Anaesthesiologica Scandinavica

Volumn 52, Issue 8, 2008, Pages 1124-1130

  Schmidt, A ^a,c   Oye I ^b   Akeson J ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Anaesthesia; Cerebral blood flow; Enantiomers; Intracranial pressure; Intravenous; Ketamine; Porcine; R ketamine; Racemic; S ketamine; Xenon

Indexed keywords

DESFLURANE; FENTANYL; KETAMINE; PROPOFOL; VECURONIUM;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BALLOON CATHETER; BRAIN BLOOD FLOW; CONTINUOUS INFUSION; CONTROLLED STUDY; HEMODYNAMICS; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; INTRACRANIAL PRESSURE; KETAMINE; REGIONAL BLOOD FLOW; STEREOISOMERISM; SWINE;

EID: 49849099656     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2008.01698.x     Document Type: Article

References (24)

1. Åkeson J, Nilsson F, Ryding E et al. A porcine model for sequential assessments of cerebral haemodynamics and metabolism. Acta Anaesthesiol Scand 1992 36 : 419 26.
2. Nilsson F, Åkeson J, Messeter K et al. A porcine model for evaluation of cerebral haemodynamics and metabolism during increased intracranial pressure. Acta Anaesthesiol Scand 1995 39 : 827 34.
3. Schmidt A, Øye I, Åkeson J. Cerebral physiological responses to bolus injection of racemic, S(+)- or R(-)-ketamine in the pig. Acta Anaesthesiol Scand 2005 49 : 1436 42.
4. Rothman SM, Thurston JH, Hauhart RE et al. Ketamine protects hippocampal neurons from anoxia in vitro. Neuroscience 1987 21 : 673 8.
5. Church J, Zeman S, Lodge D. The neuroprotective action of ketamine and MK-801 after transient cerebral ischemia in rats. Anesthesiology 1988 69 : 702 9.
6. Hoffmann WE, Pelligrino D, Werner C et al. Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats. Anesthesiology 1992 76 : 755 62.
7. Reeker C, Werner C, Möllenberg O et al. High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats. Can J Anesth 2000 47 : 572 8.
8. Himmelseher S, Pfenninger E, Georgieff M. The effect of ketamine-isomers on neuronal injury and regeneration in rat hippocampal neurons. Anesth Analg 1996 83 : 505 12.
9. Proescholdt M, Heimann A, Kempski O. Neuroprotection of S(+)-ketamine isomer in global forebrain ischemia. Brain Res 2001 904 : 245 51.
10. 2-agonist dexmedetomidine and the N-methyl-d-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg 2003 96 : 524 31.
11. Gardner AE, Olson BE, Lichtiger M. Cerebrospinal-fluid pressure during dissociative anesthesia with ketamine. Anesthesiology 1971 35 : 226 8.
12. Shapiro HM, Wyte SR, Harris AB. Ketamine anaesthesia in patients with intracranial pathology. Br J Anaesth 1972 44 : 1200 4.
13. Gibbs JM. The effect of intravenous ketamine on cerebrospinal fluid pressure. Br J Anaesth 1972 44 : 1298 302.
14. Bourgoin A, Albanèse J, Léone M et al. Effects of sufentanil or ketamine administered in target-controlled infusion on the cerebral hemodynamics of severely brain-injured patients. Crit Care Med 2005 33 : 1109 13.
15. Mayberg TS, Lam AM, Matta BF et al. Ketamine does not increase cerebral blood flow velocity or intracranial pressure during isoflurane/nitrous oxide anesthesia in patients undergoing craniotomy. Anesth Analg 1995 81 : 84 9.
16. Albanèse J, Arnaud S, Rey M et al. Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Anesthesiology 1997 87 : 1328 34.
17. Bourgoin A, Albanèse J, Wereszczynski N et al. Safety of sedation with ketamine in severe head injury patients: comparison with sufentanil. Crit Care Med 2003 31 : 711 7.
18. Schmittner MD, Vajkoczy SL, Horn P et al. Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and on need of vasopressors in patients with intracranial pathologies. J Neurosurg Anesthesiol 2007 19 : 257 62.
19. Pfenninger E, Ahnefeld FW, Grünert A. Untersuchung zum intrakraniellen Druckverhalten unter Ketaminapplikation bei erhaltener Spontanatmung. Anaesthesist 1985 34 : 191 6.
20. Pfenninger E, Grünert A, Bowdler I et al. The effect of ketamine on intracranial pressure during haemorrhagic shock under the conditions of both spontaneous breathing and controlled ventilation. Acta Neurochir 1985 78 : 113 8.
21. Kolenda H, Gremmelt A, Rading S et al. Ketamine for analgosedative therapy in intensive care treatment of head-injury patients. Acta Neurochir 1996 138 : 1193 9.
22. White PF, Ham J, Way WL et al. Pharmacology of ketamine isomers in surgical patients. Anesthesiology 1980 52 : 231 9.
23. White PF, Schuttler J, Shafer A et al. Comparative pharmacology of the ketamine isomers: studies in volunteers. Br J Anaesth 1985 57 : 197 203.
24. Långsjö JW, Maksimow A, Salmi E et al. S-Ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans. Anesthesiology 2005 103 : 258 68.