Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 5, 2008, Pages 1331-1337

  Ozbek, Zeynep ^a   Kucukali, Cem Ismail ^b   Ozkok, Elif ^c   Orhan, Nurcan ^c   Aydin, Makbule ^c   Kilic, Gamze ^d   Sazci, Ali ^e   Kara, Ihsan ^c  

^a Eyup State Hospital   (Turkey)

^b Istanbul Erenkoy Psychiatric and Neurological Disorders Hospital   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e KOCAELI UNIVERSITY   (Turkey)

Author keywords

Bipolar disorder; Homocysteine; MTHFR; Relatives; Vitamin B12

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; CYANOCOBALAMIN; FOLIC ACID; GLUTAMIC ACID; HOMOCYSTEINE; VALINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CHEMOLUMINESCENCE; CONTROLLED STUDY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENDER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; RELATIVE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

ADULT; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; FAMILY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; FOLIC ACID; GENE FREQUENCY; GENOTYPE; HOMOCYSTINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; VITAMIN B 12;

EID: 49849092516     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.04.016     Document Type: Article

References (58)

1. Alessio A.C.M., Annichino-Bizzacchi J.M., Bydlowski S.P., Eberlin M.N., Vellasca A.P., and Hoehr N.F. Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children. Am J Med Genet 128A (2004) 256-260
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental disorder. American Psychiatric Association. 4th ed (1994), American Psychiatric Press, Washington DC
3. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
4. Bjelland I., Tell G.S., Vollset S.E., Refsum H., and Ueland P.M. Folate, vitamin B12, homocysteine, and the MTHFR 677CÄT polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry 6 (2003) 618-626
5. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev 54 (1996) 382-390
6. Bottiglieri T., Laundy M., Crellin R., Toone B.K., Carney M.W., and Reynolds E.H. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 3 (2001) 419
7. Brattström L., Lindgren A., Israelsson B., Andersson A., and Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 236 (1994) 633-641
8. Carmel R., Green R., Rosenblatt D.S., and Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program (2003) 62-81
9. Carney M.W., Chary T.K., Laundy M., Bottiglieri T., Chanarin I., Reynolds E.H., et al. Red cell folate concentrations in psychiatric patients. J Affect Disord 3 (1990) 207-213
10. Chouinard, G, Ross-Chouinard, A, 1984. Extrapyramidal Symptom Rating Scale, (ESRS). Montreal, the authors. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 2005; 1: 59-65.
11. Coppen A., and Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J of Psychopharmacol 19 (2005) 59-65
12. Cortese C., and Motti C. MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr 2B (2001) 493-497
13. Endicott J., and Spitzer R.L. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35 (1978) 837-862
14. Fraguas Jr. R., Papakostas G.I., Mischoulon D., Bottiglieri T., Alpert J., and Fava M. Anger attacks in major depressive disorder and serum levels of homocysteine. Biological Psychiatry 3 (2006) 270-274
15. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1 (1995) 111-113
16. Godfrey P.S., Toone B.K., Carney M.W., Flynn T.G., Bottiglieri T., Laundy M., et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet 8712 (1990) 392-395
17. Goff D.C., Bottiglieri T., Arning E., Shih V., Freudenreich O., Evins A.E., et al. Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry 161 (2004) 1705-1708
18. Jacques P.F., Bostom A.G., Williams R.R., Ellison R.C., Eckfeldt J.H., Rosenberg I.H., et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93 (1996) 7-9
19. Kara I., Sazci A., Ergul E., Kaya G., and Kilic G. Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 111 (2003) 84-90
20. Kempisty B., Mostowska A., Gorska I., Luczak M., Czerski P., Szczepankiewicz A., et al. Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia. Neurosci Lett 3 (2006) 267-271
21. Kempisty B., Bober A., Luczak M., Czerski P., Szczepankiewicz A., Hauser J., et al. Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. Eur Psychiatry 1 (2007) 39-43
22. Kunugi H., Fukuda R., Hattori M., Kato M., Tatsumi M., Sakai T., et al. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Mol Psychiatry 5 (1998) 435-437
23. Lewis C.M., Levinson D.F., Wise L.H., et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 1 (2003) 34-48
24. Licinio J. Gene-environment interactions in molecular psychiatry. Mol Psychiatry 7 (2002) 123-124
25. Lievers K.J., Boers G.H., Verhoef P., den Heijer M., Kluijtmans L.A., van der Put N.M., et al. A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med 79 (2001) 522-528
26. Linnebank M., Homberger A., Nowak-Göttl U., Marquardt T., Harms E., and Koch H.G. Linkage disequilibrium of the common mutations 677C>T and 1298A>C of the human methylenetetrahydrofolate reductase gene as proven by the novel polymorphisms 129C>T, 1068C>T. Eur J Pediatr 159 (2000) 472-473
27. Liu C.S., Chen C.H., Chiang H.C., Kuo C.L., Huang C.S., Cheng W.L., et al. B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects. Eur J Clin Nutr 61 (2007) 996-1003
28. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71 (2000) 121-138
29. Mamdani F., Jaitovich G.I., Alda M., and Turecki G. Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications. Curr Psychiatry Rep 5 (2003) 484-492
30. Melo S.S., Persuhn D.C., Meirelles M.S., Jordao A.A., and Vannucchi H. G1793A polymorphisms in the methylene-tetrahydrofolate gene: effect of folic acid on homocysteine levels. Mol Nutr Food Res 8 (2006) 769
31. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from nucleated cells. Nucleic Acids Res 16 (1988) 1215
32. Murray R.M., Sham P., Van Os J., Zanelli J., Cannon M., and McDonald C. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr Res 71 (2004) 405-416
33. Nishimura M., Yoshino K., Tomita Y., Takashima J., Tanaka J., Narisawa K., et al. Central and peripheral nervous system pathology of homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency. Pediatr Neurol 6 (1985) 375-378
34. Nygard O., Vollset S.E., Refsum H., Stensvold I., Tverdal A., Nordrehaug J.E., et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 274 (1995) 1526-1533
35. Nygard O., Refsum H., Ueland P.M., and Vollset S.E. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 67 (1998) 263-270
36. Osher Y., Sela B.A., Levine J., and Belmaker R.H. Elevated homocysteine levels in euthymic bipolar disorder patients showing functional deterioration. Bipolar Disord 1 (2004) 82-86
37. O'Suilleabhain P.E., Sung V., Hernandez C., Lacritz L., Dewey Jr. R.B., Bottiglieri T., et al. Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol 6 (2004) 865-868
38. Overal J.E., and Gorhan D.R. The Brief Psychiatric Rating Scale. Psychol Rep 10 (1962) 799-812
39. Picker J.D., and Coyle J.T. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?. Harv Rev Psychiatry 4 (2005) 197-205
40. Regland B., Johansson B.V., and Gottfries C.G. Homocysteinemia and schizophrenia as a case of methylation deficiency. J Neural Transm Gen Sect 2 (1994) 143-152
41. Regland B., Johansson B.V., Grenfeldt B., Hjelmgren L.T., and Medhus M. Homocysteinemia is a common feature of schizophrenia. J Neural Transm Gen Sect 2 (1995) 165-169
42. Reif A., Pfuhlmann B., and Lesch K.P. Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses. Prog Neuropsycholpharmacol Biol Psychiatry 29 (2005) 1162-1168
43. Reynolds E.H. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 3 (1976) 661-696
44. Rozen R. Molecular genetics of methylenetetrahydrofolate reductase deficiency. J Inherit Metab Dis 19 (1996) 589-594
45. Schatz R.A., Wilens T.E., and Sellinger O.Z. Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine. Biochem Biophys Res Commun 4 (1981) 1097-1107
46. Segurado R., Detera-Wadleigh S.D., Levinson D.F., et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 1 (2003) 49-62
47. Selhub J.L., and Miller J.W. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transulfuration of homocysteine. Am J Clin Nutr 55 (1991) 131-138
48. Sherer M.A., Cantoni M.A., Golden R.N., Rudorfer M.V., and Potter W.Z. Effects of S-adenosyl-methionine on plasma norepinephrine, blood pressure, and heart rate in healthy volunteers. Psychiatry Res 2 (1986) 111-118
49. Shi M., Caprau D., Romitti P., Christensen K., and Murray C.K. Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2. Birth Defects Res A Clin Mol Teratol 8 (2003) 545-549
50. Swann A.C., Geller B., Post R.M., Altshuler L., Chang K.D., Delbello M.P., et al. Practical clues to early recognition of bipolar disorder: a primary care approach. Prim Care Companion J Clin Psychiat 7 (2005) 15-21
51. Ueland P.M., Refsum H., Stabler S.P., Malinow M.R., Andersson A., and Allen R.H. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 9 (1993) 1764-1779
52. Ulvik A., Ueland M., Fredriksen A., Meyer K., Vollset S.E., Hoff G., et al. Functional inference of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms from a large-scale epidemiological study. Hum Genet 1 (2007) 57-64
53. van Der Put N.M., Gabreels F., Stevens E.M., Smeitink J.A., Trijbels F.J., Eskes T.K., et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet 62 (1998) 1044-1051
54. Weisberg I., Tran P., Christensen B., Sibani S., and Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 4 (1999) 511-512
55. Weisberg I.S., Jacques P.F., Selhub J., Bostom A.G., Chen Z., Curtis Ellison R., et al. The 1298AÄC polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156 (2001) 409-415
56. Winokur G., Tsuang M.T., and Crowe R.R. The Iowa 500: affective disorder in relatives of manic and depressed patients. Am J Psychiatry 139 (1982) 209-212
57. Young R.C., Bigss J.T., Ziegler V.E., and Meyer D.A. A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry 133 (1978) 429-435
58. Zintzaras E., and Ionnidis J.P. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 2 (2005) 123-137