The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 1, 2008, Pages

  Chantler, Paul D ^a   Melenovsky, Vojtech ^b   Schulman, Steven P ^c   Gerstenblith, Gary ^c   Becker, Lewis C ^c   Ferrucci, Luigi ^a   Fleg, Jerome L ^d   Lakatta, Edward G ^a   Najjar, Samer S ^a,e  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e HARBOR HOSPITAL   (United States)

Author keywords

Arterial elastance; Exercise; Left ventricular end systolic elastance; Sex; Systolic hypertension

Indexed keywords

ADULT; ARTERY COMPLIANCE; ARTICLE; CONTROLLED STUDY; CYCLING; EXERCISE; FEMALE; HEART STROKE VOLUME; HEART VOLUME; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REST; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; AGED; BLOOD PRESSURE; BRACHIAL ARTERY; COMPARATIVE STUDY; ELASTICITY; GATED IMAGING; HEART LEFT VENTRICLE FUNCTION; HYPERTENSION; MIDDLE AGED; PATHOPHYSIOLOGY; SCINTISCANNING; SYSTOLE;

ADULT; AGED; BLOOD PRESSURE; BRACHIAL ARTERY; CARDIAC VOLUME; ELASTICITY; EXERCISE; FEMALE; GATED BLOOD-POOL IMAGING; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; SEX FACTORS; STROKE VOLUME; SYSTOLE; VENTRICULAR FUNCTION, LEFT;

EID: 49849086406     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01179.2007     Document Type: Article

References (45)

1. Ahlund C, Pettersson K, Lind L. Pulse wave analysis on fingertip arterial pressure: effects of age, gender and stressors on reflected waves and their relation to brachial and femoral artery blood flow. Clin Physiol Funct Imaging 28: 86-95, 2008.
2. Asanoi H, Sasayama S, Kameyama T. Ventriculoarterial coupling in normal and failing heart in humans. Circ Res 65: 483-493, 1989.
3. Berry KL, Cameron JD, Dart AM, Dewar EM, Gatzka CD, Jennings GL, Liang YL, Reid CM, Kingwell BA. Large-artery stiffness contributes to the greater prevalence of systolic hypertension in elderly women. J Am Geriatr Soc 52: 368-373, 2004.
4. Bing OH, Conrad CH, Boluyt MO, Robinson KG, Brooks WW. Studies of prevention, treatment and mechanisms of heart failure in the aging spontaneously hypertensive rat. Heart Fail Rev 7: 71-88, 2002.
5. Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 114: 2138-2147, 2006.
6. Burkhoff D, Sagawa K. Ventricular efficiency predicted by an analytical model. Am J Physiol Regul Integr Comp Physiol 250: R1021-R1027, 1986.
7. Chen CH, Fetics B, Nevo E, Rochitte CE, Chiou KR, Ding PA, Kawaguchi M, Kass DA. Noninvasive single-beat determination of left ventricular end-systolic elastance in humans. J Am Coll Cardiol 38: 2028-2034, 2001.
8. Chen CH, Nakayama M, Nevo E, Fetics BJ, Maughan WL, Kass DA. Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol 32: 1221-1227, 1998.
9. Cohen-Solal A, Caviezel B, Himbert D, Gourgon R. Left ventricular-arterial coupling in systemic hypertension: analysis by means of arterial effective and left ventricular elastances. J Hypertens 12: 591-600, 1994.
10. Cohen-Solal A, Caviezel B, Laperche T, Gourgon R. Effects of aging on left ventricular-arterial coupling in man: assessment by means of arterial effective and left ventricular elastances. J Hum Hypertens 10: 111-116, 1996.
11. Franklin SS. Hypertension in older people: part 1. J Clin Hypertens (Greenwich) 8: 444-449, 2006.
12. Franklin SS, Jacobs MJ, Wong ND, L'Italien GJ, Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension 37: 869-874, 2001.
13. Hayward CS, Kelly RP. Gender-related differences in the central arterial pressure waveform. J Am Coll Cardiol 30: 1863-1871, 1997.
14. Ingwall JS, Weiss RG. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95: 135-145, 2004.
15. Kass DA. Age-related changes in ventricular-arterial coupling: pathophysiologic implications. Heart Fail Rev 7: 51-62, 2002.
16. Kass DA. Ventricular arterial stiffening: integrating the pathophysiology. Hypertension 46: 185-193, 2005.
17. Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS, Kass DA. Effective arterial elastance as index of arterial vascular load in humans. Circulation 86: 513-521, 1992.
18. Kitzman DW, Higginbotham MB, Cobb FR, Sheikh KH, Sullivan MJ. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism. J Am Coll Cardiol 17: 1065-1072, 1991.
19. Klapholz M, Maurer M, Lowe AM, Messineo F, Meisner JS, Mitchell J, Kalman J, Phillips RA, Steingart R. Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York heart failure registry. J Am Coll Cardiol 43: 1432-1438, 2004.
20. Krumholz HM, Larson M, Levy D. Sex differences in cardiac adaptation to isolated systolic hypertension. Am J Cardiol 72: 310-313, 1993.
21. Lightfoot JT. Can blood pressure be measured during exercise? A review. Sports Med 12: 290-301, 1991.
22. Little WC, Cheng CP. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol Heart Circ Physiol 264: H1629-H1633, 1993.
23. Little WC, Cheng CP. Left ventricular-arterial coupling in conscious dogs. Am J Physiol Heart Circ Physiol 261: H70-H76, 1991.
24. McGandy RB, Barrows CH Jr, Spanias A, Meredith A, Stone JL, Norris AH. Nutrient intakes and energy expenditure in men of different ages. J Gerontol 21: 581-587, 1966.
25. Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol 49: 198-207, 2007.
26. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension 43: 1239-1245, 2004.
27. Najjar SS, Schulman SP, Gerstenblith G, Fleg JL, Kass DA, O'Connor F, Becker LC, Lakatta EG. Age and gender affect ventricular-vascular coupling during aerobic exercise. J Am Coll Cardiol 44: 611-617, 2004.
28. Nichols WW, O'Rourke, editor MF. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. New York: Hodder Arnold, 2005, p. 616.
29. Nussbacher A, Gerstenblith G, O'Connor FC, Becker LC, Kass DA, Schulman SP, Fleg JL, Lakatta EG. Hemodynamic effects of unloading the old heart. Am J Physiol Heart Circ Physiol 277: H1863-H1871, 1999.
30. O'Rourke MF, Nichols WW. Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension 45: 652-658, 2005.
31. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 112: 2254-2262, 2005.
32. Renlund DG, Lakatta EG, Fleg JL, Becker LC, Clulow JF, Weisfeldt ML, Gerstenblith G. Prolonged decrease in cardiac volumes after maximal upright bicycle exercise. J Appl Physiol 63: 1947-1955, 1987.
33. Roman MJ, Ganau A, Saba PS, Pini R, Pickering TG, Devereux RB. Impact of arterial stiffening on left ventricular structure. Hypertension 36: 489-494, 2000.
34. Saba PS, Ganau A, Devereux RB, Pini R, Pickering TG, Roman MJ. Impact of arterial elastance as a measure of vascular load on left ventricular geometry in hypertension. J Hypertens 17: 1007-1015, 1999.
35. Saba PS, Roman MJ, Ganau A, Pini R, Jones EC, Pickering TG, Devereux RB. Relationship of effective arterial elastance to demographic and arterial characteristics in normotensive and hypertensive adults. J Hypertens 13: 971-977, 1995.
36. Sagawa K, Suga H, Shoukas AA, Bakalar KM. End-systolic pressure/volume ratio: a new index of ventricular contractility. Am J Cardiol 40: 748-753, 1977.
37. Schulman SP, Lakatta EG, Fleg JL, Lakatta L, Becker LC, Gerstenblith G. Age-related decline in left ventricular filling at rest and exercise. Am J Physiol Heart Circ Physiol 263: H1932-H1938, 1992.
38. Shock NWG, Greulich RC, Andres R, Arenberg D, Costa PT Jr, Lakatta EG, Tobin JD. Normal Human Aging: The Baltimore Longitudinal Study of Aging. Washington, DC: Superintendent of Documents, U.S. Government Printing Office, 1984, p. 425.
39. Starling MR. Left ventricular-arterial coupling relations in the normal human heart. Am Heart J 125: 1659-1666, 1993.
40. Suga H. Global cardiac function: mechano-energetico-informatics. J Biomech 36: 713-720, 2003.
41. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K. Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol Heart Circ Physiol 245: H773-H780, 1983.
42. Sunagawa K, Sugimachi M, Todaka K, Kobota T, Hayashida K, Itaya R, Chishaki A, Takeshita A. Optimal coupling of the left ventricle with the arterial system. Basic Res Cardiol 88, Suppl 2: 75-90, 1993.
43. Talbot LA, Metter EJ, Fleg JL. Leisure-time physical activities and their relationship to cardiorespiratory fitness in healthy men and women 18-95 years old. Med Sci Sports Exerc 32: 417-425, 2000.
44. Van den Horn GJ, Westerhof N, Elzinga G. Optimal power generation by the left ventricle. A study in the anesthetized open thorax cat. Circ Res 56: 252-261, 1985.
45. Wilkinson IB, MacCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol 525: 263-270, 2000.