Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 1, 2008, Pages

  Guo, Donglin ^a   Young, Lindon ^b   Patel, Chinmay ^a   Jiao, Zhen ^a   Wu, Ying ^a   Liu, Tengxian ^a   Kowey, Peter R ^a   Yan, Gan Xin ^a,c  

^a Main Line Health Heart Center   (United States)

^b PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

T wave alternans

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; RYANODINE; CHLORIDE CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHLORIDE CURRENT; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART PACING; HEART REPOLARIZATION; HEART VENTRICLE CONTRACTION; MALE; MEMBRANE POTENTIAL; MUSCLE ACTION POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL; RABBIT; T WAVE; ACTION POTENTIAL; ANIMAL; CALCIUM SIGNALING; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENDOCARDIUM; HEART ARRHYTHMIA; HEART CONTRACTION; METABOLISM; PATHOPHYSIOLOGY; PERICARDIUM; TIME;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; 4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID; ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; CHLORIDE CHANNELS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ENDOCARDIUM; HYPERTROPHY, LEFT VENTRICULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PERICARDIUM; RABBITS; RYANODINE; TIME FACTORS;

EID: 49849083158     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01032.2007     Document Type: Article

References (47)

1. Benitah JP, Gomez AM, Delgado C, Lorente P, Lederer WJ. A chloride current component induced by hypertrophy in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 272: H2500-H2506, 1997.
2. Beuckelmann DJ, Nabauer M, Erdmann E. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055, 1992.
3. Bloomfield DM, Magnano AR, Parides MK. Comparison of T-wave alternans testing during treadmill and bicycle exercise in patients with congestive heart failure. Am J Cardiol 91: 1493-1497, 2003.
4. 2+ ions as initiators of arrhythmias. J Cardiovasc Electrophysiol 12: 382-385, 2001.
5. 2+ oscillations. Science 279: 227-230, 1998.
6. Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. Two types of transient outward currents in adult human atrial cells. Am J Physiol Heart Circ Physiol 252: H142-H148, 1987.
7. Guo D, Zhao X, Wu Y, Liu T, Kowey PR, Yan GX. L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. J Cardiovasc Electrophysiol 18: 196-203, 2007.
8. Han W, Chartier D, Li D, Nattel S. Ionic remodeling of cardiac Purkinje cells by congestive heart failure. Circulation 104: 2095-2100, 2001.
9. Hennersdorf MG, Perings C, Niebch V, Vester EG, Strauer BE. T wave alternans as a risk predictor in patients with cardiomyopathy and mild-to-moderate heart failure. Pacing Clin Electrophysiol 23: 1386-1391, 2000.
10. Hill AP, Sitsapesan R. DIDS modifies the conductance, gating, and inactivation mechanisms of the cardiac ryanodine receptor. Biophys J 82: 3037-3047, 2002.
11. Hirayama Y, Saitoh H, Atarashi H, Hayakawa H. Electrical and mechanical alternans in canine myocardium in vivo. Dependence on intracellular calcium cycling. Circulation 88: 2894-2902, 1993.
12. Iyer V, Hajjar RJ, Armoundas AA. Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia. Circ Res 100: e22-e31, 2007.
13. Janse MJ. Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res 61: 208-217, 2004.
14. Josephson IR, Sanchez-Chapula J, Brown AM. Early outward current in rat single ventricular cells. Circ Res 54: 157-162, 1984.
15. 2+ pump function to electrical and mechanical alternans. J Electrocardiol 36: 125-135, 2003.
16. 2+-sensitive transient outward current in rabbit ventricular myocytes. J Physiol 486: 593-604, 1995.
17. 2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles. Am J Physiol Heart Circ Physiol 261: H1746-H1755, 1991.
18. Klingenheben T, Zabel M, D'Agostino RB, Cohen RJ, Hohnloser SH. Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. Lancet 356: 651-652, 2000.
19. +. Cardiovasc Res 41: 175-187, 1999.
20. Lab MJ, Lee JA. Changes in intracellular calcium during mechanical alternans in isolated ferret ventricular muscle. Circ Res 66: 585-595, 1990.
21. Lee HC, Mohabir R, Smith N, Franz MR, Clusin WT. Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction. Circulation 78: 1047-1059, 1988.
22. 2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents. Am J Physiol Heart Circ Physiol 292: H2854-H2866, 2007.
23. Madias JE. Reproducibility of T-wave alternans in congestive heart failure: a theoretical argument. Pacing Clin Electrophysiol 29: 800-802, 2006.
24. 2+ -release mechanism in A7r5 cells. Mol Pharmacol 68: 241-250, 2005.
25. Narayan SM, Smith JM, Lindsay BD, Cain ME, Davila-Roman VG. Relation of T-wave alternans to regional left ventricular dysfunction and eccentric hypertrophy secondary to coronary heart disease. Am J Cardiol 97: 775-780, 2006.
26. Nuss HB, Kaab S, Kass DA, Tomaselli GF, Marban E. Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol Heart Circ Physiol 277: H80-H91, 1999.
27. O'Neill ER, Sakowska MM, Laver DR. Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. Biophys J 84: 1674-1689, 2003.
28. Orchard CH, McCall E, Kirby MS, Boyett MR. Mechanical alternans during acidosis in ferret heart muscle. Circ Res 68: 69-76, 1991.
29. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99: 1385-1394, 1999.
30. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 85: 1009-1019, 1999.
31. Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ Res 94: 1083-1090, 2004.
32. Rials SJ, Wu Y, Xu X, Filart RA, Marinchak RA, Kowey PR. Regression of left ventricular hypertrophy with captopril restores normal ventricular action potential duration, dispersion of refractoriness, and vulnerability to inducible ventricular fibrillation. Circulation 96: 1330-1336, 1997.
33. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ. Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 330: 235-241, 1994.
34. Saitoh H, Bailey JC, Surawicz B. Alternans of action potential duration after abrupt shortening of cycle length: differences between dog Purkinje and ventricular muscle fibers. Circ Res 62: 1027-1040, 1988.
35. Saitoh H, Bailey JC, Surawicz B. Action potential duration alternans in dog Purkinje and ventricular muscle fibers. Further evidence in support of two different mechanisms. Circulation 80: 1421-1431, 1989.
36. Shimizu W, Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation 99: 1499-1507, 1999.
37. Sipido KR, Volders PG, Vos MA, Verdonck F. Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res 53: 782-805, 2002.
38. Spear JF, Moore EN. A comparison of alternation in myocardial action potentials and contractility. Am J Physiol 220: 1708-1716, 1971.
39. Tomaselli GF, Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42: 270-283, 1999.
40. - current reduces transmural electrical heterogeneity within the rabbit left ventricle. Acta Physiol Scand 180: 239-247, 2004.
41. Verkerk AO, Veldkamp MW, Baartscheer A, Schumacher CA, Klopping C, van Ginneken AC, Ravesloot JH. Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts. Circulation 104: 2728-2733, 2001.
42. Walker ML, Wan X, Kirsch GE, Rosenbaum DS. Hysteresis effect implicates calcium cycling as a mechanism of repolarization alternans. Circulation 108: 2704-2709, 2003.
43. Wohlfart B. Analysis of mechanical alternans in rabbit papillary muscle. Acta Physiol Scand 115: 405-414, 1982.
44. Xu X, Rials SJ, Wu Y, Salata JJ, Liu T, Bharucha DB, Marinchak RA, Kowey PR. Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits. Circulation 103: 1585-1590, 2001.
45. Yan GX, Rials SJ, Wu Y, Liu T, Xu X, Marinchak RA, Kowey PR. Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization. Am J Physiol Heart Circ Physiol 281: H1968-H1975, 2001.
46. Yan GX, Wu Y, Liu T, Wang J, Marinchak RA, Kowey PR. Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: direct evidence from intracellular recordings in the intact left ventricular wall. Circulation 103: 2851-2856, 2001.
47. Zygmunt AC, Gibbons WR. Properties of the calcium-activated chloride current in heart. J Gen Physiol 99: 391-414, 1992.