메뉴 건너뛰기




Volumn 7, Issue 16, 2008, Pages 2452-2455

Modulation of the "blood-tumor" barrier improves immunotherapy

Author keywords

Adoptive transfer; Angiogenesis; Immunotherapy; Regulator of G protein signaling 5; Vascular barrier; Vessel normalization

Indexed keywords

REGULATOR OF PROTEIN SIGNALING 5; RGS PROTEIN;

EID: 49749149560     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.16.6451     Document Type: Review
Times cited : (28)

References (43)
  • 1
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 1972; 175:409-16.
    • (1972) Ann Surg , vol.175 , pp. 409-416
    • Folkman, J.1
  • 2
    • 34249689557 scopus 로고    scopus 로고
    • VEGF-targeted cancer therapy strategies: Current progress, hurdles and future prospects
    • Duda DG, Batchelor TT, Willett CG, Jain RK. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med 2007; 13:223-30.
    • (2007) Trends Mol Med , vol.13 , pp. 223-230
    • Duda, D.G.1    Batchelor, T.T.2    Willett, C.G.3    Jain, R.K.4
  • 5
    • 0032532318 scopus 로고    scopus 로고
    • Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
    • Ganss R, Hanahan D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res 1998; 58:4673-81.
    • (1998) Cancer Res , vol.58 , pp. 4673-4681
    • Ganss, R.1    Hanahan, D.2
  • 6
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss R, Ryschich E, Klar E, Arnold B, Hammerling GJ. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res 2002; 62:1462-70.
    • (2002) Cancer Res , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hammerling, G.J.5
  • 7
    • 0037138426 scopus 로고    scopus 로고
    • Transformation of the microvascular system during multistage tumorigenesis
    • Ryschich E, Schmidt J, Hammerling GJ, Klar E, Ganss R. Transformation of the microvascular system during multistage tumorigenesis. Int J Cancer 2002; 97:719-25.
    • (2002) Int J Cancer , vol.97 , pp. 719-725
    • Ryschich, E.1    Schmidt, J.2    Hammerling, G.J.3    Klar, E.4    Ganss, R.5
  • 11
    • 43049147611 scopus 로고    scopus 로고
    • Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice
    • Hamzah J, Nelson D, Moldenhauer G, Arnold B, Hammerling GJ, Ganss R. Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice. J Clin Invest 2008; 118:1691-9.
    • (2008) J Clin Invest , vol.118 , pp. 1691-1699
    • Hamzah, J.1    Nelson, D.2    Moldenhauer, G.3    Arnold, B.4    Hammerling, G.J.5    Ganss, R.6
  • 12
    • 0242266120 scopus 로고    scopus 로고
    • Tumor microvasculature as a barrier to antitumor immunity
    • Chen Q, Wang WC, Evans SS. Tumor microvasculature as a barrier to antitumor immunity. Cancer Immunol Immunother 2003; 52:670-9.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 670-679
    • Chen, Q.1    Wang, W.C.2    Evans, S.S.3
  • 13
    • 7244260416 scopus 로고    scopus 로고
    • Mini-review: Overcoming tumor-intrinsic resistance to immune effector function
    • Ganss R, Arnold B, Hammerling GJ. Mini-review: overcoming tumor-intrinsic resistance to immune effector function. Eur J Immunol 2004; 34:2635-41.
    • (2004) Eur J Immunol , vol.34 , pp. 2635-2641
    • Ganss, R.1    Arnold, B.2    Hammerling, G.J.3
  • 14
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: A review
    • Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988; 48:2641-58.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 15
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - an obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 2004; 4:806-13.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 16
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 17
    • 12844255716 scopus 로고    scopus 로고
    • Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
    • Berger M, Bergers G, Arnold B, Hammerling GJ, Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood 2005; 105:1094-101.
    • (2005) Blood , vol.105 , pp. 1094-1101
    • Berger, M.1    Bergers, G.2    Arnold, B.3    Hammerling, G.J.4    Ganss, R.5
  • 19
    • 0029016245 scopus 로고
    • T lymphocyte adhesion to human brain pericytes is mediated via very late antigen-4/vascular cell adhesion molecule-1 interactions
    • Verbeek MM, Westphal JR, Ruiter DJ, de Waal RM. T lymphocyte adhesion to human brain pericytes is mediated via very late antigen-4/vascular cell adhesion molecule-1 interactions. J Immunol 1995; 154:5876-84.
    • (1995) J Immunol , vol.154 , pp. 5876-5884
    • Verbeek, M.M.1    Westphal, J.R.2    Ruiter, D.J.3    de Waal, R.M.4
  • 20
    • 0030270961 scopus 로고    scopus 로고
    • Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996; 32:687-98.
    • Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996; 32:687-98.
  • 21
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005; 7:452-64.
    • (2005) Neuro Oncol , vol.7 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 22
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998; 125:1591-8.
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 24
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111:1287-95.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 25
    • 45049087009 scopus 로고    scopus 로고
    • RGS5 expression is a quantitative measure of pericyte coverage of blood vessels
    • Mitchell TS, Bradley J, Robinson GS, Shima DT, Ng YS. RGS5 expression is a quantitative measure of pericyte coverage of blood vessels. Angiogenesis 2008; 11:141-51.
    • (2008) Angiogenesis , vol.11 , pp. 141-151
    • Mitchell, T.S.1    Bradley, J.2    Robinson, G.S.3    Shima, D.T.4    Ng, Y.S.5
  • 26
    • 26944437515 scopus 로고    scopus 로고
    • PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005; 7:870-9.
    • (2005) Nat Cell Biol , vol.7 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 28
    • 0345505671 scopus 로고    scopus 로고
    • Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    • Bondjers C, Kalen M, Hellstrom M, Scheidl SJ, Abramsson A, Renner O, Lindahl P, Cho H, Kehrl J, Betsholtz C. Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol 2003; 162:721-9.
    • (2003) Am J Pathol , vol.162 , pp. 721-729
    • Bondjers, C.1    Kalen, M.2    Hellstrom, M.3    Scheidl, S.J.4    Abramsson, A.5    Renner, O.6    Lindahl, P.7    Cho, H.8    Kehrl, J.9    Betsholtz, C.10
  • 29
    • 0037365902 scopus 로고    scopus 로고
    • Pericyte-specific expression of Rgs5: Implications for PDGF and EDG receptor signaling during vascular maturation
    • Cho H, Kozasa T, Bondjers C, Betsholtz C, Kehrl JH. Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. Faseb J 2003; 17:440-2.
    • (2003) Faseb J , vol.17 , pp. 440-442
    • Cho, H.1    Kozasa, T.2    Bondjers, C.3    Betsholtz, C.4    Kehrl, J.H.5
  • 30
    • 0030933718 scopus 로고    scopus 로고
    • Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast
    • Chen C, Zheng B, Han J, Lin SC. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem 1997; 272:8679-85.
    • (1997) J Biol Chem , vol.272 , pp. 8679-8685
    • Chen, C.1    Zheng, B.2    Han, J.3    Lin, S.C.4
  • 31
    • 0031737333 scopus 로고    scopus 로고
    • Cardiac myocytes express mRNA for ten RGS proteins: Changes in RGS mRNA expression in ventricular myocytes and cultured atria
    • Kardestuncer T, Wu H, Lim AL, Neer EJ. Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria. FEBS Lett 1998; 438:285-8.
    • (1998) FEBS Lett , vol.438 , pp. 285-288
    • Kardestuncer, T.1    Wu, H.2    Lim, A.L.3    Neer, E.J.4
  • 32
    • 0034730815 scopus 로고    scopus 로고
    • A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media
    • Adams LD, Geary RL, McManus B, Schwartz SM. A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Circ Res 2000; 87:623-31.
    • (2000) Circ Res , vol.87 , pp. 623-631
    • Adams, L.D.1    Geary, R.L.2    McManus, B.3    Schwartz, S.M.4
  • 36
    • 0141868753 scopus 로고    scopus 로고
    • A culture device demonstrates that hydrostatic pressure increases mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells
    • Manome Y, Saeki N, Yoshinaga H, Watanabe M, Mizuno S. A culture device demonstrates that hydrostatic pressure increases mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells. Cells Tissues Organs 2003; 174:155-61.
    • (2003) Cells Tissues Organs , vol.174 , pp. 155-161
    • Manome, Y.1    Saeki, N.2    Yoshinaga, H.3    Watanabe, M.4    Mizuno, S.5
  • 37
    • 2442452552 scopus 로고    scopus 로고
    • CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
    • Garbi N, Arnold B, Gordon S, Hammerling GJ, Ganss R. CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction. J Immunol 2004; 172:5861-9.
    • (2004) J Immunol , vol.172 , pp. 5861-5869
    • Garbi, N.1    Arnold, B.2    Gordon, S.3    Hammerling, G.J.4    Ganss, R.5
  • 38
    • 0027299866 scopus 로고
    • Homing of naive, memory and effector lymphocytes
    • Mackay CR. Homing of naive, memory and effector lymphocytes. Curr Opin Immunol 1993; 5:423-7.
    • (1993) Curr Opin Immunol , vol.5 , pp. 423-427
    • Mackay, C.R.1
  • 39
    • 0036733358 scopus 로고    scopus 로고
    • Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling
    • Hollinger S, Hepler JR. Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev 2002; 54:527-59.
    • (2002) Pharmacol Rev , vol.54 , pp. 527-559
    • Hollinger, S.1    Hepler, J.R.2
  • 40
    • 0036490096 scopus 로고    scopus 로고
    • Regulators of G-protein signalling as new central nervous system drug targets
    • Neubig RR, Siderovski DP. Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov 2002; 1:187-97.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 187-197
    • Neubig, R.R.1    Siderovski, D.P.2
  • 41
    • 0031698405 scopus 로고    scopus 로고
    • Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif
    • Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Ohhira M, Muramatsu M, Hori T, Saito T. Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif. J Hum Genet 1998; 43:272-4.
    • (1998) J Hum Genet , vol.43 , pp. 272-274
    • Seki, N.1    Hattori, A.2    Sugano, S.3    Suzuki, Y.4    Nakagawara, A.5    Ohhira, M.6    Muramatsu, M.7    Hori, T.8    Saito, T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.