Age-related changes in the human thymus studied with scanning electron microscopy

Microscopy Research and Technique

Volumn 71, Issue 8, 2008, Pages 573-578

  Cavallotti, Carlo ^a   D'Andrea, Vito ^a   Tonnarini, Gianfranco ^a   Cavallotti, Chiara ^a   Bruzzone, Paolo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Aging; Endothelial cells; Humans; Loose gaps; Scanning electron microscopy; Thymocytes; Thymus microvessels

Indexed keywords

BLOOD VESSELS; CYTOLOGY; DIAGNOSIS; ENDOTHELIAL CELLS; THYMUS;

AGE-RELATED CHANGES; ELECTRON MICROSCOPIC OBSERVATIONS; ENDOTHELIAL-CELLS; HUMAN; LOOSE GAP; MICROVESSELS; QUANTITATIVE RESULT; SCANNING ELECTRON MICROSCOPIC; THYMOCYTES; THYMUS MICROVESSEL;

SCANNING ELECTRON MICROSCOPY;

ADIPOCYTE; ADULT; AGED; AGING; ARTICLE; BIOPSY; CLINICAL ARTICLE; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; LYMPHOID CELL; MALE; MICROVASCULATURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; STATISTICAL ANALYSIS; THORAX SURGERY; THYMOCYTE; THYMUS; TISSUE SECTION;

EID: 49749135227     PISSN: 1059910X     EISSN: 10970029     Source Type: Journal    
DOI: 10.1002/jemt.20588     Document Type: Article

References (29)

1. Aspinall R. 2003. Age-related changes in the function of T-cells. Microsc Res Technol 62:508-513.
2. Barrat F, Lesourd B, Boulouis HJ, Pilet C. 1999. Aging and the immune system. Experimental aspects. Bull Acad Natl Med 183:1137-1148.
3. Benz C, Heinzel K, Bleul CC. 2004. Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T-cell development. J Immunol 34:3652-3663.
4. Capri M, Monti D, Salvioli S, Lescai F, Pierini M, Altilia S, Sevini F, Valensin S, Ostan R, Bucci L, Franceschi C. 2006. Complexity of anti-immune-senescence strategies in humans. Artif Organs 30:730-742.
5. Castino M, Roletto E. 1992. Statistica applicata, 3rd ed. Padua: Piccin.
6. Contreiras EC, Lenzi HL, Meirelles MN, Caputo LF, Calado TJ, Villa-Verde DM, Savino W. 2004. The equine thymus micro-environment a morphological and immunohistochemical analysis. Dev Comp Immunol 28:251-264.
7. Douek DC, Koup RA. 2000. Evidence for thymic function in the elderly. Vaccine 18:1638-1641.
8. Douek DC, McFarland RD, Keiser PH. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690-695.
9. Duijvestijn AM, Hoefsmit EC. 1981. Ultrastructure of the rat thymus: The micro-environment of T-lymphocyte maturation. Cell Tissue Res 218:279-286.
10. Effros RB. 2001. Ageing and the immune system. Novartis Found Symp 235:130-139.
11. Gruver AL, Hudson LL, Sempowski GD. 2007. Immunosenescence of ageing. J Pathol 211:144-156.
12. Hannestad J, Monjil DF, Diaz-Esnal B, Cobo J, Vega JA. 2004. Age-dependent changes in the nervous and endocrine control of the thymus. Microsc Res Technol 63:94-101.
13. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. 2000. The role of the thymus in immune reconstitution in aging bone marrow transplantation and HIV-1 infection. Annu Rev Immunol 18:529-560.
14. Kuwabara H, Krenacs T, Hirano H, Nishio H, Shikata T, Kizaki T, Nagai M, Suzuki K, Mori H. 2002. Immunolocalization of peripheral lymphonode addressins in normal and neoplastic human thymuses. Appl Immunohistochem Mol Morphol 10:253-257.
15. Lacorre DA, Baekkevold ES, Garrido I, Brandtzaeg P, Haraldsen G, Amalric F, Girard JP. 2004. Plasticity of endothelial cells: Rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment. Blood 103:4164-4172.
16. Linton PJ, Dorshkind K. 2004. Age-related changes in lymphocyte development and function. Nat Immunol 5:33-139.
17. MacKey I. 1972. Aging and immunological function in man. Gerontologia 18:285-304.
18. Leica. 1997. Manual of methods Quantimet 500 Leica. Cambridge, UK: Microsystems Imaging Solutions.
19. Mazzoccoli G, Correra M, Bianco G, De Cata A, Balzanelli M, Giuliani A, Tarquini R. 1997. Age-related changes of neuro-endocrine-immune interactions in the healthy humans. J Biol Regul Homeost Agents 11:143-147.
20. Milicevic NM, Milicevic Z. 2000. Ultrastructural identification of specialized endocytic compartments in macrophages of the thymic cortico-medulla zone and germinal centers of peripheral lymphatic organs of rat. Ann Anat 182:471-478.
21. Oviedo-Orta E, Errington RJ, Evans WH. 2002. Gap junction intercellular communication during lymphocyte trans-endothelial migration. Cell Biol Int 26:253-263.
22. Pawelec G, Effros RB, Caruso C, Remarque E, Barnett Y, Solana RT. 1999. Cells and aging. Front Biosci 26:216-269.
23. Romanyukha AA, Yashin AI. 2003. Age related changes in population of peripheral T-cells: Towards a model of immunosenescence. Mech Ageing Dev 124:433-443.
24. Savino W, Mendes-Da-Cruz DA, Smaniotto S, Silva-Monteiro E, Villa-Verde DM. 2004. Molecular mechanisms governing thymocyte migration: Combined role of chemochines and extracellular matrix. J Leukoc Biol 75:951-961.
25. Sempowski GD, Haynes BF. 2002. Immune reconstitution in patients with HIV infection. Annu Rev Med 53:269-284.
26. Sisko I. 2001. Ultrastructural morphometric analysis of thymus epithelial cells two months after pinealectomy. Ital J Anat Embryol 106:287-294.
27. Smith EM, Blalock JE. 1988. A molecular basis for interactions between immune and neuro-endocrine systems. Int J Neurosci 38:455-464.
28. Terzakis JA. 2000. Distinguishing B and T lymphocytes by scanning electron microscopy. Ultrastruct Pathol 24:205-209.
29. Zidan M, Jecker P, Pabst R. 2000. Differences in lymphocyte subsets in the wall of high endothelial venules and the lymphatic of human palatine tonsils. Scand J Immunol 51:372-376.