Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome

British Journal of Dermatology

Volumn 159, Issue 3, 2008, Pages 744-746

  Hosomi, N ^a   Fukai, K ^a   Nakanishi, T ^a   Funaki, S ^a   Ishii, M ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Caspase 1; Interleukin 18; Netherton syndrome; SPINK5

Indexed keywords

CARRIER PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN SPINK5; UNCLASSIFIED DRUG;

ADULT; ANAMNESIS; CASE REPORT; CLINICAL FEATURE; ENZYME ACTIVITY; EXON; FEMALE; HUMAN; LABORATORY TEST; LETTER; MALE; NETHERTON DISEASE; NONSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STRATUM CORNEUM;

ADULT; CASPASE 1; DERMATITIS, ATOPIC; EPIDERMIS; FEMALE; HAIR DISEASES; HUMANS; ICHTHYOSIS; INTERLEUKIN-18; MALE; SYNDROME;

EID: 49749125061     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08706.x     Document Type: Letter

References (9)

1. Greene SL, Muller SA. Netherton's syndrome. Report of a case and review of the literature. J Am Acad Dermatol 1985 13 : 329 37.
2. Chavanas S, Bodemer C, Rochat A et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 2000 25 : 141 2.
3. Yoshimoto T, Mizutani H, Tsutsui H et al. IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000 1 : 132 7.
4. Ghayur T, Banerjee S, Hugunin M et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997 386 : 619 23.
5. Komatsu N, Takata M, Otsuki N et al. Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol 2002 118 : 436 43.
6. Yoshizawa Y, Nomaguchi H, Izaki S et al. Serum cytokine levels in atopic dermatitis. Clin Exp Dermatol 2002 27 : 225 9.
7. Hilbi H, Puro RJ, Zychlinsky A. Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infect Immun 2000 68 : 5502 8.
8. Johansen C, Moeller K, Kragballe K et al. The activity of caspase-1 is increased in lesional psoriatic epidermis. J Invest Dermatol 2007 127 : 2857 64.
9. Ishida-Yamamoto A, Deraison C, Bonnart C et al. LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J Invest Dermatol 2005 124 : 360 6.