Direct and acute cardiotoxic effects of ultrafine air pollutants in spontaneously hypertensive rats and Wistar-Kyoto rats

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 13, Issue 3, 2008, Pages 189-198

  Hwang, Hyosook ^a   Kloner, Robert A ^a,b   Kleinman, Michael T ^c   Simkhovich, Boris Z ^a,b  

^a GOOD SAMARITAN HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Arterial hypertension; Cardiac contractile function; Isolated heart; Ultrafine particles

Indexed keywords

AIR POLLUTANT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART FUNCTION; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; ULTRAFINE PARTICLE; WISTAR KYOTO RAT;

ANIMALS; BLOOD PRESSURE; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; FEMALE; GASOLINE; HEART; HYPERTENSION; MYOCARDIAL CONTRACTION; PARTICLE SIZE; PARTICULATE MATTER; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 49749123899     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248408321569     Document Type: Article

References (37)

1. Brook RD, Franklin B., Cascio W., et al. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation. 2004 ; 109: 2655-2671.
2. Ibald-Mulli A., Timonen KL, Peters A., et al. Effects of particulate air pollution on blood pressure and heart rate in subjects with cardiovascular disease: a multicenter approach. Environ Health Perspect. 2004 ; 112: 369-377.
3. Kunzli N., Jerrett M., Mack WJ, et al. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect. 2005 ; 113: 201-206.
4. Peters A., Dockery DW, Muller JE, Mittleman MA Increased particulate air pollution and the triggering of myocardial infarction. Circulation. 2001 ; 103: 2810-2815.
5. Peters A., Liu E., Verrier RL, et al. Air pollution and incidence of cardiac arrhythmia. Epidemiology. 2000 ; 11: 11-17.
6. Pope CA 3rd, Burnett RT, Thurston GD, et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 2004 ; 109: 71-77.
7. Cozzi E., Hazarika S., Stallings HW 3rd, et al. Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol. 2006 ; 291: H894 - H903.
8. Gold DR, Litonjua A., Schwartz J., et al. Ambient pollution and heart rate variability. Circulation. 2000 ; 101: 1267-1273.
9. Wold LE, Simkhovich BZ, Kleinman MT, et al. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovasc Toxicol. 2006 ; 6: 69-78.
10. Nemmar A., Hoet PH, Vanquickenborne B., et al. Passage of inhaled particles into the blood circulation in humans. Circulation. 2002 ; 105: 411-414.
11. Nemmar A., Hoylaerts MF, Hoet PH, Nemery B. Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects. Toxicol Lett. 2004 ; 149: 243-253.
12. Fields LE, Burt VL, Cutler JA, Hughes J., Roccella EJ, Sorlie P. The burden of adult hypertension in the United States 1999 to 2000: a rising tide. Hypertension. 2004 ; 44: 398-404.
13. Oparil S., Zaman MA, Calhoun DA Pathogenesis of hypertension. Ann Intern Med. 2003 ; 139: 761-776.
14. Shorofsky SR, Aggarwal R., Corretti M., et al. Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks. Circ Res. 1999 ; 84: 424-434.
15. Zicha J., Kunes J. Ontogenetic aspects of hypertension development: analysis in the rat. Physiol Rev. 1999 ; 79: 1227-1282.
16. Simkhovich BZ, Marjoram P., Kleinman MT, Kloner RA Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. Basic Res Cardiol. 2007 ; 102: 467-475.
17. Dominici F., Peng RD, Bell ML, et al. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA. 2006 ; 295: 1127-1134.
18. Pope CA 3rd, Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation. 2006 ; 114: 2443-2448.
19. Suwa T., Hogg JC, Quinlan KB, Ohgami A., Vincent R., van Eeden SF Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol. 2002 ; 39: 935-942.
20. Yuan YV, Kitts DD, Godin DV Heart and red blood cell antioxidant status and plasma lipid levels in the spontaneously hypertensive and normotensive Wistar-Kyoto rat. Can J Physiol Pharmacol. 1996 ; 74: 290-297.
21. Chuang KJ, Chan CC, Chen NT, Su TC, Lin LY Effects of particle size fractions on reducing heart rate variability in cardiac and hypertensive patients. Environ Health Perspect. 2005 ; 113: 1693-1697.
22. Holguin F., Tellez-Rojo MM, Hernandez M., et al. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology. 2003 ; 14: 521-527.
23. Safar M., Chamiot-Clerc P., Dagher G., Renaud JF Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats. Hypertension. 2001 ; 38: 1416-1421.
24. Brook RD, Brook JR, Urch B., Vincent R., Rajagopalan S., Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation. 2002 ; 105: 1534-1536.
25. Mills NL, Tornqvist H., Robinson SD, et al. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation. 2005 ; 112: 3930-3936.
26. Pekkanen J., Peters A., Hoek G., et al. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation. 2002 ; 106: 933-938.
27. Salvi S., Blomberg A., Rudell B., et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 1999 ; 159: 702-709.
28. Wellenius GA, Saldiva PH, Batalha JR, et al. Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction. Toxicol Sci. 2002 ; 66: 327-335.
29. Bagate K., Meiring JJ, Gerlofs-Nijland ME, Vincent R., Cassee FR, Borm PJ Vascular effects of ambient particulate matter instillation in spontaneous hypertensive rats. Toxicol Appl Pharmacol. 2004 ; 197: 29-39.
30. Bai Y., Suzuki AK, Sagai M. The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species. Free Radic Biol Med. 2001 ; 30: 555-562.
31. Bouthillier L., Vincent R., Goegan P., et al. Acute effects of inhaled urban particles and ozone: lung morphology, macrophage activity, and plasma endothelin-1. Am J Pathol. 1998 ; 153: 1873-1884.
32. Li Z., Hyseni X., Carter JD, Soukup JM, Dailey LA, Huang YC Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2006 ; 291: C357 - C365.
33. Gurgueira SA, Lawrence J., Coull B., Murthy GG, Gonzalez- Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect. 2002 ; 110: 749-755.
34. Li N., Sioutas C., Cho A., et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003 ; 111: 455-460.
35. Renna BF, MacDonnell SM, Reger PO, Crabbe DL, Houser SR, Libonati JR Relative systolic dysfunction in female spontaneously hypertensive rat myocardium. J Appl Physiol. 2007 ; 103: 353-358.
36. Renna BF, Kubo H., MacDonnell SM, et al. Enhanced acidotic myocardial Ca2+ responsiveness with training in hypertension. Med Sci Sports Exerc. 2006 ; 38: 847-855.
37. Watters T., Wikman-Coffelt J., Wu S., James TL, Sievers R., Parmley WW Effects of perfusion pressure on energy and work of isolated rat hearts. Hypertension. 1989 ; 13: 480-488.